Results 21 to 30 of about 57,421 (279)

A simple, highly sensitive, and facile method to quantify ceramide at the plasma membrane

Journal of Lipid Research, 2023
The role of ceramide in biological functions is typically based on the elevation of cellular ceramide, measured by LC-MS in the total cell lysate. However, it has become increasingly appreciated that ceramide in different subcellular organelles regulates
Meaghan Greene, Maria Jose Hernandez-Corbacho, Anne G. Ostermeyer-Fay, Yusuf A. Hannun, Daniel Canals   +4 more
doaj   +1 more source

Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells : role of sphingosine kinase 1 and S1P lyase [PDF]

, 2011
Earlier we have shown that extracellular sphingosine-1-phosphate (S1P) induces migration of human pulmonary artery endothelial cells (HPAECs) through the activation of S1P(1) receptor, PKCε, and PLD2-PKCζ-Rac1 signaling cascade.
Sabbadini Roger A., Satish Kalari, Nigel J. Pyne (356726), Garcia, Joe G N, Pyne Nigel J., Nigel J Pyne, Susan Pyne (356727), Natarajan Viswanathan, Pyne, S, Zhao, Y, Roger A. Sabbadini (7924547), Berdyshev, Evgeny V, Garcia, JGN, Roger A Sabbadini, Peter Usatyuk (356723), Garcia Joe G. N., Satish Kalari (307462), Nigel J. Pyne, Berdyshev Evgeny V., Natarajan, V, Usatyuk, Peter, Yutong Zhao, Kalari Satish, Garcia, Joe G.N., Usatyuk, P, Kalari, S, Sabbadini, RA, Viswanathan Natarajan, Roger A. Sabbadini, Joe G. N. Garcia (7923365), Evgeny V Berdyshev, Zhao Yutong, Joe G N Garcia, Sabbadini, Roger A, Pyne, Nigel J, Pyne, NJ, Pyne Susan, Yutong Zhao (356724), Evgeny V. Berdyshev (7924544), Irina Gorshkova (356721), Gorshkova, Irina, Usatyuk Peter, Kalari, Satish, Pyne, Susan, Irina Gorshkova, Gorshkova, I, Evgeny V. Berdyshev, Joe G. N. Garcia, Gorshkova Irina, Peter Usatyuk, Natarajan, Viswanathan, Berdyshev, EV, Susan Pyne, Zhao, Yutong, Viswanathan Natarajan (307479)   +54 more
core   +1 more source

TNF-α plays a role in hepatocyte apoptosis in Niemann-Pick type C liver disease

Journal of Lipid Research, 2009
Niemann-Pick type C (NPC) is a fatal autosomal recessive lysosomal storage disease clinically characterized by neurodegeneration and liver disease.
Victoria M. Rimkunas, Mark J. Graham, Rosanne M. Crooke, Laura Liscum   +3 more
doaj   +1 more source

Sphingosine kinase and sphingosine 1-phosphate in asthma

Bioscience Reports, 2010
Sphingolipids are amphiphatic molecules ubiquitously expressed in all eukaryotic cell membranes. Initially characterized as structural components of cell membranes, sphingolipids have emerged as sources of important signalling molecules over the past decade.
Wen-Qi, Lai, W S Fred, Wong, Bernard P, Leung   +2 more
openaire   +2 more sources

Biochemical studies on sphingolipids of Artemia franciscana: novel neutral glycosphingolipids[S]

Journal of Lipid Research, 2011
Neutral glycosphingolipids containing one to six sugars in their oligosaccharide chains have been isolated from cysts of the brine shrimp Artemia franciscana.
Hisao Kojima, Takemasa Shimizu, Mutsumi Sugita, Saki Itonori, Norihisa Fujita, Masahiro Ito   +5 more
doaj   +1 more source

Fingolimod modulates microglial activation to augment markers of remyelination [PDF]

, 2011
Introduction Microglial activation in multiple sclerosis has been postulated to contribute to long-term neurodegeneration during disease. Fingolimod has been shown to impact on the relapsing remitting phase of disease by modulating autoreactive T-cell ...
Giovannoni Gavin, Jackson Samuel J, Jackson, SJ, Baker, D, Gavin Giovannoni, Baker David, Giovannoni, G, David Baker, Samuel J Jackson   +8 more
core   +1 more source

Signaling at the membrane interface by the DGK/SK enzyme family

Journal of Lipid Research, 2009
The sphingosine (SK) and diacylglycerol (DGK) kinases have become the subject of considerable focus recently due to their involvement as signaling enzymes in a variety of important biological processes.
Daniel M. Raben, Binks W. Wattenberg
doaj   +1 more source

Brown Adipose Transplantation Improves Polycystic Ovary Syndrome-Involved Metabolome Remodeling

Frontiers in Endocrinology, 2021
Polycystic ovary syndrome (PCOS) is a complex reproductive, endocrine, and metabolic disorder in reproductive-age women. In order to explore the active metabolites of brown adipose tissue (BAT) transplantation in improving the reproductive and metabolic ...
Lihua Yao, Lihua Yao, Qin Wang, Qin Wang, Runjie Zhang, Runjie Zhang, Xingyun Wang, Xingyun Wang, Yiwen Liu, Yiwen Liu, Fangfang Di, Fangfang Di, Liwen Song, Liwen Song, Siliang Xu   +14 more
doaj   +1 more source

1-Deoxysphinganine initiates adaptive responses to serine and glycine starvation in cancer cells via proteolysis of sphingosine kinase

Journal of Lipid Research, 2022
Cancer cells may depend on exogenous serine, depletion of which results in slower growth and activation of adaptive metabolic changes. We previously demonstrated that serine and glycine (SG) deprivation causes loss of sphingosine kinase 1 (SK1) in cancer
Jean-Philip Truman, Christian F. Ruiz, Emily Montal, Monica Garcia-Barros, Izolda Mileva, Ashley J. Snider, Yusuf A. Hannun, Lina M. Obeid, Cungui Mao   +8 more
doaj   +1 more source

Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery [PDF]

, 2010
<b>BACKGROUND AND PURPOSE</b> Anandamide and sphingosine-1-phosphate (S1P) both regulate vascular tone in a variety of vessels. This study aimed to examine the mechanisms involved in the regulation of coronary vascular tone by anandamide and ...
Kane, K.A., Brett, R.R., Mair, K.M., Kennedy, S., Pyne, N.J., Pyne, S., Robinson, E.   +6 more
core   +1 more source