Sphingosine kinase and sphingosine 1-phosphate in asthma
Bioscience Reports, 2010 Sphingolipids are amphiphatic molecules ubiquitously expressed in all eukaryotic cell membranes. Initially characterized as structural components of cell membranes, sphingolipids have emerged as sources of important signalling molecules over the past decade.
Wen-Qi, Lai +2 more
openaire +2 more sources
Biochemical studies on sphingolipids of Artemia franciscana: novel neutral glycosphingolipids[S]
Journal of Lipid Research, 2011 Neutral glycosphingolipids containing one to six sugars in their oligosaccharide chains have been isolated from cysts of the brine shrimp Artemia franciscana.
Hisao Kojima +5 more
doaj +1 more source
Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer [PDF]
Discover Oncology, 2021 AbstractSphingosine-1-phosphate (S1P), a pleiotropic lipid mediator, participates in various cellular processes during tumorigenesis, including cell proliferation, survival, drug resistance, metastasis, and angiogenesis. S1P is formed by two sphingosine kinases (SphKs), SphK1 and SphK2. The intracellularly produced S1P is delivered to the extracellular
Guangmeng Xu +4 more
openaire +3 more sources
Sphingosine 1-phosphate modulates antigen capture by murine langerhans cells via the S1P2 receptor subtype [PDF]
, 2012 Dendritic cells (DCs) play a pivotal role in the development of cutaneous contact hypersensitivity (CHS) and atopic dermatitis as they capture and process antigen and present it to T lymphocytes in the lymphoid organs.
Kleuser, Burkhard (Prof. Dr. rer. nat.) +13 more
core +1 more source
Signaling at the membrane interface by the DGK/SK enzyme family
Journal of Lipid Research, 2009 The sphingosine (SK) and diacylglycerol (DGK) kinases have become the subject of considerable focus recently due to their involvement as signaling enzymes in a variety of important biological processes.
Daniel M. Raben, Binks W. Wattenberg
doaj +1 more source
Brown Adipose Transplantation Improves Polycystic Ovary Syndrome-Involved Metabolome Remodeling
Frontiers in Endocrinology, 2021 Polycystic ovary syndrome (PCOS) is a complex reproductive, endocrine, and metabolic disorder in reproductive-age women. In order to explore the active metabolites of brown adipose tissue (BAT) transplantation in improving the reproductive and metabolic ...
Lihua Yao +14 more
doaj +1 more source
Journal of Lipid Research, 2022 Cancer cells may depend on exogenous serine, depletion of which results in slower growth and activation of adaptive metabolic changes. We previously demonstrated that serine and glycine (SG) deprivation causes loss of sphingosine kinase 1 (SK1) in cancer
Jean-Philip Truman +8 more
doaj +1 more source
Inhibition of acid sphingomyelinase disrupts LYNUS signaling and triggers autophagy
Journal of Lipid Research, 2018 Activation of the lysosomal ceramide-producing enzyme, acid sphingomyelinase (ASM), by various stresses is centrally involved in cell death and has been implicated in autophagy.
Matthew J. Justice +6 more
doaj +1 more source
Gas-liquid chromatography-mass spectrometry of synthetic ceramides
Journal of Lipid Research, 1969 Two series of ceramides with either sphingosine (sphing-4-enine) or sphinganine as base and with one of the saturated fatty acids C16, C18, C20, C22, C24, C26, or oleic acid were analyzed as the 1,3-di-O-trimethylsilyl ether derivatives by gas ...
Bengt Samuelsson, Karin Samuelsson
doaj +1 more source
Fingolimod modulates microglial activation to augment markers of remyelination [PDF]
, 2011 Introduction Microglial activation in multiple sclerosis has been postulated to contribute to long-term neurodegeneration during disease. Fingolimod has been shown to impact on the relapsing remitting phase of disease by modulating autoreactive T-cell ...
Giovannoni Gavin +8 more
core +1 more source