Results 41 to 50 of about 84,296 (269)

Sphingosine kinase and sphingosine 1-phosphate in asthma

Bioscience Reports, 2010
Sphingolipids are amphiphatic molecules ubiquitously expressed in all eukaryotic cell membranes. Initially characterized as structural components of cell membranes, sphingolipids have emerged as sources of important signalling molecules over the past decade.
Wen-Qi, Lai, W S Fred, Wong, Bernard P, Leung   +2 more
openaire   +2 more sources

FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination. [PDF]

, 2014
BackgroundFTY720 (fingolimod) is the first oral drug approved by the Food and Drug Administration for treatment of patients with the relapsing-remitting form of the human demyelinating disease multiple sclerosis.
Blanc, Caroline A, Lane, Thomas E, Rosen, Hugh   +2 more
core   +1 more source

Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa

EMBO Molecular Medicine, 2014
Cystic fibrosis patients and patients with chronic obstructive pulmonary disease, trauma, burn wound, or patients requiring ventilation are susceptible to severe pulmonary infection by Pseudomonas aeruginosa.
Yael Pewzner‐Jung, Shaghayegh Tavakoli Tabazavareh, Heike Grassmé, Katrin Anne Becker, Lukasz Japtok, Jörg Steinmann, Tammar Joseph, Stephan Lang, Burkhard Tuemmler, Edward H Schuchman, Alex B Lentsch, Burkhard Kleuser, Michael J Edwards, Anthony H Futerman, Erich Gulbins   +14 more
doaj   +1 more source

Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: Review of sphingosine kinase inhibitors [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2013
Sphingosine 1-phosphate (S1P) is an important bioactive sphingolipid metabolite that has been implicated in numerous physiological and cellular processes. Not only does S1P play a structural role in cells by defining the components of the plasma membrane, but in the last 20 years it has been implicated in various significant cell signaling pathways and
K Alexa, Orr Gandy, Lina M, Obeid
openaire   +2 more sources

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A‐RIPK1‐dependent necroptosis

EMBO Molecular Medicine, 2012
Mechanisms that alter protein phosphatase 2A (PP2A)‐dependent lung tumour suppression via the I2PP2A/SET oncoprotein are unknown. We show here that the tumour suppressor ceramide binds I2PP2A/SET selectively in the nucleus and including its K209 and Y122
Sahar A. Saddoughi, Salih Gencer, Yuri K. Peterson, Katherine E. Ward, Archana Mukhopadhyay, Joshua Oaks, Jacek Bielawski, Zdzislaw M. Szulc, Raquela J. Thomas, Shanmugam P. Selvam, Can E. Senkal, Elizabeth Garrett‐Mayer, Ryan M. De Palma, Dzmitry Fedarovich, Angen Liu, Amyn A. Habib, Robert V. Stahelin, Danilo Perrotti, Besim Ogretmen   +18 more
doaj   +1 more source

Defective CFTR increases synthesis and mass of sphingolipids that modulate membrane composition and lipid signaling

Journal of Lipid Research, 2009
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) that affect protein structure and channel function.
Hiroko Hamai, Fannie Keyserman, Lynne M. Quittell, Tilla S. Worgall   +3 more
doaj   +1 more source

Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma [PDF]

, 2015
The prevalence of global obesity is increasing. Obesity is associated with general cancer-related morbidity and mortality and is a known risk factor for development of specific cancers.
Alfraidi, Albandri, Alshaker, Heba, Muhammad, Aun, Pchejetski, Dmitri, Sacco, Keith, Winkler, Mathias   +5 more
core   +2 more sources

Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis

Journal of Lipid Research, 2006
Ceramides (Cers) accumulate within the interstices of the outermost epidermal layers, or stratum corneum (SC), where they represent critical components of the epidermal permeability barrier.
Evi Houben, Walter M. Holleran, Toshiaki Yaginuma, Cungui Mao, Lina M. Obeid, Vera Rogiers, Yutaka Takagi, Peter M. Elias, Yoshikazu Uchida   +8 more
doaj   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

Serum sphingosine negatively correlates with albumin predicting the risk of hepatocellular carcinoma

Biomedical Papers, 2020
Background: The roles of sphingosine in various cancers have not been fully investigated. Our aim was to identify the relationship between serum sphingosine and the risk of hepatocellular carcinoma (HCC).
Kai Huang, Wanlian Li, Juan Xiao, Diteng Luo, Junfei Jin   +4 more
doaj   +1 more source