Results 1 to 10 of about 9,200 (222)

Sphinganine-Analog Mycotoxins (SAMs): Chemical Structures, Bioactivities, and Genetic Controls [PDF]

Journal of Fungi (Basel, Switzerland), 2020
Sphinganine-analog mycotoxins (SAMs) including fumonisins and A. alternata f. sp. Lycopersici (AAL) toxins are a group of related mycotoxins produced by plant pathogenic fungi in the Fusarium genus and in Alternaria alternata f. sp.
Yi Cheng, Tu-Hong Wang, Jian-Ping Xu
exaly   +5 more sources

Dietary sphinganine is selectively assimilated by members of the mammalian gut microbiome

Journal of Lipid Research, 2021
Functions of the gut microbiome have a growing number of implications for host metabolic health, with diet being one of the most significant influences on microbiome composition.
Elizabeth L Johnson
exaly   +3 more sources

A novel fluorescein sodium-based screening platform for the identification of sphingoid base-producing Wickerhamomyces ciferrii mutants [PDF]

Frontiers in Bioengineering and Biotechnology
The efficient identification of microbial strains capable of producing rare sphingoid bases, such as sphingosine and sphinganine, is critical for advancing microbial fermentation processes and addressing increasing industrial demands.
Jun Su Kang, Seong-Rae Lee, Minju Lee, Eunha Kim, Pyung Cheon Lee   +4 more
doaj   +2 more sources

Bioactivity-Guided Fractionation, Characterization, and Mechanistic Insights of Anticancer Agents from Simarouba glauca DC. Leaves [PDF]

Molecules
Although Simarouba glauca DC. has been recognized for its therapeutic properties, its anticancer effects against oral cancer have not been adequately investigated. The present study aimed to evaluate the activity of S.
Sushma Rudraswamy, Yashaswini Devi G. V., Sreeshyla H. Sheshanna, Nagabhushana Doggalli, SubbaRao V. Madhunapantula   +4 more
doaj   +2 more sources

Identification and characterization of 3-ketosphinganine reductase activity encoded at the BT_0972 locus in Bacteroides thetaiotaomicron

Journal of Lipid Research, 2022
Bacterial sphingolipid synthesis is important for the fitness of gut commensal bacteria with an implied potential for regulating mammalian host physiology.
Min-Ting Lee, Henry H. Le, Kevin R. Besler, Elizabeth L. Johnson   +3 more
doaj   +1 more source

Circulating sepsis-related metabolite sphinganine could protect against intestinal damage during sepsis

Frontiers in Immunology, 2023
IntroductionSepsis is intricately linked to intestinal damage and barrier dysfunction. At present times, there is a growing interest in a metabolite-based therapy for multiple diseases.MethodsSerum samples from septic patients and healthy individuals ...
Zetian Wang, Yue Qi, Fei Wang, Baiyin Zhang, Tang Jianguo   +4 more
doaj   +1 more source

Characterization of a Bacterial Kinase That Phosphorylates Dihydrosphingosine to Form dhS1P

Microbiology Spectrum, 2022
Like other members of the phylum Bacteroidetes, the oral anaerobe Porphyromonas gingivalis synthesizes a variety of sphingolipids, similar to its human host.
Dev K. Ranjit, Zachary D. Moye, Fernanda G. Rocha, Gregory Ottenberg, Frank C. Nichols, Hey-Min Kim, Alejandro R. Walker, Frank C. Gibson, Mary E. Davey   +8 more
doaj   +1 more source

Strong Alterations in the Sphingolipid Profile of Chickens Fed a Dose of Fumonisins Considered Safe

Toxins, 2021
Fumonisins (FB) are mycotoxins known to exert most of their toxicity by blocking ceramide synthase, resulting in disruption of sphingolipid metabolism.
Didier Tardieu, Maria Matard-Mann, Pi Nyvall Collén, Philippe Guerre   +3 more
doaj   +1 more source

Effects of Fumonisin-Contaminated Corn on Growth Performance of 9 to 28 kg Nursery Pigs

Toxins, 2020
Fumonisin contamination in corn is an emerging issue in animal feed production. Fumonisin disrupts the metabolism of sphingolipids and reduces growth performance.
Zhong-Xing Rao, Mike D. Tokach, Jason C. Woodworth, Joel M. DeRouchey, Robert D. Goodband, Hilda I. Calderón, Steve S. Dritz   +6 more
doaj   +1 more source

Serum Sphingolipids Aiding the Diagnosis of Adult HIV-Negative Patients with Talaromyces marneffei Infection

Frontiers in Cellular and Infection Microbiology, 2021
Increasing attention has been directed to Talaromyces marneffei (T. marneffei) infection in HIV-negative patients due to its high mortality rate. However, nonspecific symptoms and biological characteristics similar to those of other common pathogenic ...
Zheng-Tu Li, Lee-Fong Yau, Ye Qiu, Shao-Qiang Li, Yang-Qing Zhan, Wai-Him Chan, Zhao-Ming Chen, Zhun Li, Yongming Li, Ye Lin, Jing Cheng, Jian-Quan Zhang, Zhi-Hong Jiang, Jing-Rong Wang, Feng Ye   +14 more
doaj   +1 more source