Results 1 to 10 of about 8,836 (207)

Isolation and Quantification of Sphingosine and Sphinganine from Rat Serum Revealed Gender Differences [PDF]

Biomolecules, 2019
Sphingolipids are an important group of lipids that play crucial roles in living cells, facilitating cell recognition, signal transduction and endocytosis.
Graham Brogden, Diab M. Husein, Pablo Steinberg, Hassan Y. Naim   +3 more
doaj   +3 more sources

Sphinganine recruits TLR4 adaptors in macrophages and promotes inflammation in murine models of sepsis and melanoma

Nature Communications
After recognizing its ligand lipopolysaccharide, Toll-like receptor 4 (TLR4) recruits adaptor proteins to the cell membrane, thereby initiating downstream signaling and triggering inflammation.
Marvin Hering, Alaa Madi, Roger Sandhoff, Sicong Ma, Jingxia Wu, Alessa Mieg, Karsten Richter, Kerstin Mohr, Nora Knabe, Diana Stichling, Gernot Poschet, Felix Bestvater, Larissa Frank, Jochen Utikal, Viktor Umansky, Guoliang Cui   +15 more
doaj   +3 more sources

Sphinganine-Analog Mycotoxins (SAMs): Chemical Structures, Bioactivities, and Genetic Controls

Journal of Fungi, 2020
Sphinganine-analog mycotoxins (SAMs) including fumonisins and A. alternata f. sp. Lycopersici (AAL) toxins are a group of related mycotoxins produced by plant pathogenic fungi in the Fusarium genus and in Alternaria alternata f. sp.
Jia Chen, Zhimin Li, Yi Cheng, Chunsheng Gao, Litao Guo, Tuhong Wang, Jianping Xu   +6 more
doaj   +3 more sources

Circulating sepsis-related metabolite sphinganine could protect against intestinal damage during sepsis

Frontiers in Immunology, 2023
IntroductionSepsis is intricately linked to intestinal damage and barrier dysfunction. At present times, there is a growing interest in a metabolite-based therapy for multiple diseases.MethodsSerum samples from septic patients and healthy individuals ...
Zetian Wang, Yue Qi, Fei Wang, Baiyin Zhang, Tang Jianguo   +4 more
doaj   +2 more sources

Dietary sphinganine is selectively assimilated by members of the mammalian gut microbiome

Journal of Lipid Research, 2021
Functions of the gut microbiome have a growing number of implications for host metabolic health, with diet being one of the most significant influences on microbiome composition.
Min-Ting Lee, Henry H. Le, Elizabeth L. Johnson   +2 more
doaj   +2 more sources

A rapid ceramide synthase activity using NBD-sphinganine and solid phase extraction

Journal of Lipid Research, 2015
Ceramides are synthesized by six mammalian ceramide synthases (CerSs), each of which uses fatty acyl-CoAs of different chain lengths for N-acylation of the sphingoid long-chain base. We now describe a rapid and reliable CerS assay that uses a fluorescent
Rotem Tidhar, Kacee Sims, Eden Rosenfeld-Gur, Walter Shaw, Anthony H. Futerman   +4 more
doaj   +2 more sources

Toxic C17-Sphinganine Analogue Mycotoxin, Contaminating Tunisian Mussels, Causes Flaccid Paralysis in Rodents

Marine Drugs, 2013
Severe toxicity was detected in mussels from Bizerte Lagoon (Northern Tunisia) using routine mouse bioassays for detecting diarrheic and paralytic toxins not associated to classical phytoplankton blooming. The atypical toxicity was characterized by rapid
Riadh Marrouchi, Evelyne Benoit, Jean-Pierre Le Caer, Nawel Belayouni, Hafedh Belghith, Jordi Molgó, Riadh Kharrat   +6 more
doaj   +2 more sources

A novel fluorescein sodium-based screening platform for the identification of sphingoid base-producing Wickerhamomyces ciferrii mutants [PDF]

Frontiers in Bioengineering and Biotechnology
The efficient identification of microbial strains capable of producing rare sphingoid bases, such as sphingosine and sphinganine, is critical for advancing microbial fermentation processes and addressing increasing industrial demands.
Jun Su Kang, Seong-Rae Lee, Minju Lee, Eunha Kim, Pyung Cheon Lee   +4 more
doaj   +2 more sources

Bioactivity-Guided Fractionation, Characterization, and Mechanistic Insights of Anticancer Agents from Simarouba glauca DC. Leaves [PDF]

Molecules
Although Simarouba glauca DC. has been recognized for its therapeutic properties, its anticancer effects against oral cancer have not been adequately investigated. The present study aimed to evaluate the activity of S.
Sushma Rudraswamy, Yashaswini Devi G. V., Sreeshyla H. Sheshanna, Nagabhushana Doggalli, SubbaRao V. Madhunapantula   +4 more
doaj   +2 more sources

Trifunctional Sphinganine: A New Tool to Dissect Sphingolipid Function

bioRxiv, 2023
Functions of the sphingolipids sphingosine and sphinganine in cells are not well established. While some signaling roles for sphingosine have been elucidated, the closely related sphinganine has been described only insofar as it does not elicit many of ...
Scotland Farley, F. Stein, P. Haberkant, Fikadu G. Tafesse, Carsten Schultz   +4 more
semanticscholar   +1 more source