Results 31 to 40 of about 8,836 (207)

Multi-omics association analysis reveals interactions between the oropharyngeal microbiome and the metabolome in pediatric patients with influenza A virus pneumonia

Frontiers in Cellular and Infection Microbiology, 2022
Children are at high risk for influenza A virus (IAV) infections, which can develop into severe illnesses. However, little is known about interactions between the microbiome and respiratory tract metabolites and their impact on the development of IAV ...
Qian Hu, Baiming Liu, Yanqun Fan, Yuejie Zheng, Feiqiu Wen, Uet Yu, Wenjian Wang   +6 more
doaj   +1 more source

Dose-Dependent Effects on Sphingoid Bases and Cytokines in Chickens Fed Diets Prepared with Fusarium Verticillioides Culture Material Containing Fumonisins

Toxins, 2015
In chickens, the effect of mycotoxins, especially fumonisins (FB), in the gastrointestinal tract (GIT) is not well documented. Thus, this study in broiler chicks determined the effects of consuming diets prepared with Fusarium verticillioides culture ...
Bertrand Grenier, Heidi E. Schwartz-Zimmermann, Sylvia Caha, Wulf Dieter Moll, Gerd Schatzmayr, Todd J. Applegate   +5 more
doaj   +1 more source

Ramadan intermittent fasting is associated with ameliorated inflammatory markers and improved plasma sphingolipids/ceramides in subjects with obesity: lipidomics analysis

Scientific Reports, 2023
Intermittent fasting (IF) is associated with enormous metabolic alterations that underpin its diverse health effects. Changes in lipid metabolism, particularly ceramides, and other sphingolipids, are among the most notable of these alterations.
Mohamed Ibrahim Madkour, Md Torikul Islam, Trevor S. Tippetts, Kamrul H. Chowdhury, Lisa A. Lesniewski, Scott A. Summers, Falak Zeb, Dana N. Abdelrahim, Refat AlKurd, Husam M. Khraiwesh, Katia H. AbuShihab, Asma AlBakri, Khaled Obaideen, MoezAlIslam E. Faris   +13 more
doaj   +1 more source

Synthesis of ceramides using N-hydroxysuccinimide esters

Journal of Lipid Research, 1972
Fatty acyl esters of N-hYdroxYSuccinimide have been used to directly N-acylate sphingenine or sphinganine, forming the corresponding ceramides. The reaction proceeds in excellent yield (84–96%) from small amounts of starting material (10–20 mg).
David E. Ong, Robert N. Brady
doaj   +1 more source

Hydrophilic interaction liquid chromatography–tandem mass spectrometric approach for Simultaneous Determination of Safingol and D-erythro-Sphinganine in human plasma

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2019
A simple and specific hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC-MS/MS) method was developed for the simultaneous determination of C18-L-threo-sphinganine (safingol, an anti-neoplastic in phase I trials) and its ...
Hwangeui Cho, B. Maurer, C. P. Reynolds, Min H. Kang   +3 more
semanticscholar   +1 more source

Defective CFTR increases synthesis and mass of sphingolipids that modulate membrane composition and lipid signaling

Journal of Lipid Research, 2009
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) that affect protein structure and channel function.
Hiroko Hamai, Fannie Keyserman, Lynne M. Quittell, Tilla S. Worgall   +3 more
doaj   +1 more source

A convenient procedure for the synthesis of ceramides

Journal of Lipid Research, 1971
A procedure for the preparation of ceramides by direct coupling of long-chain bases and fatty acids in the presence of a mixed carbodiimide is described.
Sven Hammarström
doaj   +1 more source

Nonselective inhibition of neutrophil functions by sphinganine

, 1987
Sphinganine has been proposed to be a specific inhibitor of protein kinase C. In the present study we have evaluated whether sphinganine is a convenient tool to probe for the role of protein kinase C in neutrophil function.
Pittet, Didier, Bruzzone, R, Lew, Daniel Pablo, Krause, Karl-Heinz, Krause, KH, Wollheim, CB, Lew, DP, Bruzzone, R., Wollheim, Claes, Pittet, D   +9 more
core   +1 more source

Vitamin K2 as a New Modulator of the Ceramide De Novo Synthesis Pathway

Molecules, 2021
The aim of the study was to evaluate the influence of vitamin K2 (VK2) supplementation on the sphingolipid metabolism pathway in palmitate-induced insulin resistant hepatocytes.
Adrian Kołakowski, Piotr F. Kurzyna, Hubert Żywno, Wiktor Bzdęga, Ewa Harasim-Symbor, Adrian Chabowski, Karolina Konstantynowicz-Nowicka   +6 more
doaj   +1 more source

Secretion of Sphinganine by Drug-Induced Cancer Cells and Modified Mimetic Sphinganine (MMS) as c-Src Kinase Inhibitor

Asian Pacific Journal of Cancer Prevention
Background: Cancer cells exhibit selective metabolic reprogramming to promote proliferation, invasiveness, and metastasis. Sphingolipids such as sphingosine and sphinganine have been reported to modulate cell death processes in cancer cells. However, the
Rasika Nandangiri, Seethamma T. N., A. K. Raj, K. Lokhande, Kratika Khunteta, Ameya Hebale, Haet Kothari, Vaidehi Patel, S. Sarode, Nilesh Kumar Sharma   +9 more
semanticscholar   +1 more source