Results 21 to 30 of about 9,200 (222)

Biosynthesis of sphinganine-analog mycotoxins

Journal of Industrial Microbiology & Biotechnology, 2008
Sphinganine-analog mycotoxins (SAMT) are polyketide-derived natural products produced by a number of plant pathogenic fungi and are among the most economically important mycotoxins. The toxins are structurally similar to sphinganine, a key intermediate in the biosynthesis of ceramides and sphingolipids, and competitive inhibitors for ceramide synthase.
L, Du, X, Zhu, R, Gerber, J, Huffman, L, Lou, J, Jorgenson, F, Yu, K, Zaleta-Rivera, Q, Wang   +8 more
openaire   +2 more sources

A fluorescent assay for ceramide synthase activity

Journal of Lipid Research, 2012
The sphingolipids are a diverse family of lipids with important roles in membrane compartmentalization, intracellular signaling, and cell-cell recognition. The central sphingolipid metabolite is ceramide, formed by the transfer of a variable length fatty
Hyun Joon Kim, Qiao Qiao, Hamish D. Toop, Jonathan C. Morris, Anthony S. Don   +4 more
doaj   +1 more source

The role of mycotoxins in the human exposome: Application of mycotoxin biomarkers in exposome-health studies [PDF]

, 2018
Mycotoxins are secondary metabolites produced by fungi that may contaminate different foods intended for human consumption, resulting in a widespread exposure worldwide. The novel exposome paradigm has the ambition to decipher the different environmental
Cano Sancho, German, Marín Sillué, Sònia, Ramos Girona, Antonio J., Sanchís Almenar, Vicente   +3 more
core   +4 more sources

Open field study of some Zea mays hybrids, lipid compounds and fumonisins accumulation [PDF]

, 2015
Lipid molecules are increasingly recognized as signals exchanged by organisms interacting in pathogenic and/or symbiotic ways. Some classes of lipids actively determine the fate of the interactions.
Battilani, Paola, Cirlini, Martin, Dall’Asta, Chiara, Fanelli, Corrado, Galaverna, Gianni, Giorni, Paola, Ludovici, Matteo, Reverberi, Massimo, Scala, Valeria   +8 more
core   +2 more sources

Thematic Review Series: Sphingolipids. Biodiversity of sphingoid bases (“sphingosines”) and related amino alcohols*

Journal of Lipid Research, 2008
“Sphingosin” was first described by J. L. W. Thudichum in 1884 and structurally characterized as 2S,3R,4E-2-aminooctadec-4-ene-1,3-diol in 1947 by Herb Carter, who also proposed the designation of “lipides derived from sphingosine as sphingolipides ...
Sarah T. Pruett, Anatoliy Bushnev, Kerri Hagedorn, Madhura Adiga, Christopher A. Haynes, M. Cameron Sullards, Dennis C. Liotta, Alfred H. Merrill, Jr.   +7 more
doaj   +1 more source

Cross-Platform Comparison of Untargeted and Targeted Lipidomics Approaches on Aging Mouse Plasma. [PDF]

, 2018
Lipidomics - the global assessment of lipids - can be performed using a variety of mass spectrometry (MS)-based approaches. However, choosing the optimal approach in terms of lipid coverage, robustness and throughput can be a challenging task.
Brunet, Anne, Contrepois, Kévin, Hornburg, Daniel, Mahmoudi, Salah, Papsdorf, Katharina, Snyder, Michael, Ubhi, Baljit K   +6 more
core   +3 more sources

Altered Levels of Sphingosine and Sphinganine in Psoriatic Epidermis [PDF]

Annals of Dermatology, 2013
Ceramides are the main lipid component of the stratum corneum and are a structurally heterogeneous and complex group of sphingolipids of which sphingoid bases are the basic structural constituents. Altered levels of sphingoid bases have been reported in skin conditions that involve dryness and barrier disruption, including atopic dermatitis.The purpose
Moon, Sung-Hyuk, Kim, Ju-Young, Song, Eun-Hwa, Shin, Min-Kyung, Cho, Yun-Hi, Kim, Nack-In   +5 more
openaire   +2 more sources

Efficacy of a Mycotoxin Binder against Dietary Fumonisin, Deoxynivalenol, and Zearalenone in Rats [PDF]

, 2011
It was hypothesized that a mycotoxin binder, Grainsure E, would inhibit adverse effects of a mixture of fumonisin B1, deoxynivalenol, and zearalenone in rats. For 14 and 28 days, 8–10 Sprague–Dawley rats were fed control diet, Grainsure E (0.5%), toxins (
Arnold D. L., Avantaggiato G., Azcona-Olivera J. I., Boutrif E., Bursian S. J., Clifford L. J., Dantzer W. R., D’Mello J. P. F., Ehrlich K. C., Gelderblom W. C., Heneweer M., Howard P. C., Kiessling K. H., Koen Meynen, Kouadio J. H., Lemmer E. R., Lun A. K., Maaroufi K., MacDonald S. J., MacDonald S. J., Mayura K., Morsy F. A., My Truong, Narins R. G., Patricia A. Murphy, Ribar S., Riley R. T., Solfrizzo M., Solfrizzo M., Sprando R. L., Suzanne Hendrich, Szkudelska K., Takemura H., Trucksess M. W., Zhiyi Qiang   +34 more
core   +3 more sources

Nonselective inhibition of neutrophil functions by sphinganine.

Journal of Biological Chemistry, 1987
Sphinganine has been proposed to be a specific inhibitor of protein kinase C. In the present study we have evaluated whether sphinganine is a convenient tool to probe for the role of protein kinase C in neutrophil function. Human neutrophils were loaded with the fluorescent probe quin2 and then tested in parallel for cytosolic free Ca2+, [Ca2+]i ...
Bruzzone, R, Pittet, D, Krause, KH, Wollheim, CB, Lew, DP   +4 more
openaire   +4 more sources

Sphingolipid Metabolism Perturbations in Rett Syndrome

Metabolites, 2019
Rett syndrome is a severe neurodevelopmental disorder affecting mostly females and is caused by loss-of-function mutations in the MECP2 gene that encoded the methyl-CpG-binding protein 2.
Gerarda Cappuccio, Taraka Donti, Michele Pinelli, Pia Bernardo, Carmela Bravaccio, Sarah H. Elsea, Nicola Brunetti-Pierri   +6 more
doaj   +1 more source