Results 21 to 30 of about 8,836 (207)
Frontiers in Cellular and Infection Microbiology, 2021 Increasing attention has been directed to Talaromyces marneffei (T. marneffei) infection in HIV-negative patients due to its high mortality rate. However, nonspecific symptoms and biological characteristics similar to those of other common pathogenic ...
Zheng-Tu Li +14 more
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Conversion of erythro-D-sphinganine to its [1-2H1] and [1-3H1] derivatives.
Journal of Lipid Research, 1984 A convenient chemical synthesis of erythro-D-[1-2H1] sphinganine and erythro-D-[1-3H1]sphinganine is described. The approach utilizes a stereospecific starting material (natural sphinganine prepared from bovine brain sphingomyelin) and applies a sequence
M W Crossman, C B Hirschberg
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Gas-liquid chromatography-mass spectrometry of synthetic ceramides
Journal of Lipid Research, 1969 Two series of ceramides with either sphingosine (sphing-4-enine) or sphinganine as base and with one of the saturated fatty acids C16, C18, C20, C22, C24, C26, or oleic acid were analyzed as the 1,3-di-O-trimethylsilyl ether derivatives by gas ...
Bengt Samuelsson, Karin Samuelsson
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Frontiers in Microbiology, 2022 Serine palmitoyltransferase (SPT) catalyzes the first and committed step in sphingolipid biosynthesis condensating L-serine and acyl-CoA to form 3-oxo-sphinganine. Whenever the structural gene for SPT is present in genomes of Rhodobacteria (α-, β-, and γ-
Jonathan Padilla-Gómez +9 more
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A fluorescent assay for ceramide synthase activity
Journal of Lipid Research, 2012 The sphingolipids are a diverse family of lipids with important roles in membrane compartmentalization, intracellular signaling, and cell-cell recognition. The central sphingolipid metabolite is ceramide, formed by the transfer of a variable length fatty
Hyun Joon Kim +4 more
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Non-Enzymatic N-Acetylation of Sphinganine with Acetyl Coenzyme A [PDF]
, 1996 Dihydroceramide, a biosynthetic precursor of ceramide, is biologically synthesized from sphinganine and fatty acyl-CoA with acyl-CoA: sphinganine N-acyltransferase.
柏木, 基, 賀佐, 伸省
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Journal of Lipid Research, 2008 “Sphingosin” was first described by J. L. W. Thudichum in 1884 and structurally characterized as 2S,3R,4E-2-aminooctadec-4-ene-1,3-diol in 1947 by Herb Carter, who also proposed the designation of “lipides derived from sphingosine as sphingolipides ...
Sarah T. Pruett +7 more
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Plant Biotechnology Journal, 2019 Summary Fumonisin B1 (FB1) and Alternaria alternate f. sp. lycopersici (AAL)‐toxin are classified as sphinganine analog mycotoxins (SAMTs), which induce programmed cell death (PCD) in plants and pose health threat to humans who consume the contaminated ...
Zhiyong Shao +9 more
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Polarized membrane traffic and cell polarity development is dependent on dihydroceramide synthase-regulated sphinganine turnover [PDF]
, 2004 Sphingoid bases have been implicated in various cellular processes including cell growth, apoptosis and cell differentiation. Here, we show that the regulated turnover of sphingoid bases is crucial for cell polarity development, i.e., the biogenesis of ...
van der Wouden, JM +9 more
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Sphingolipid Metabolism Perturbations in Rett Syndrome
Metabolites, 2019 Rett syndrome is a severe neurodevelopmental disorder affecting mostly females and is caused by loss-of-function mutations in the MECP2 gene that encoded the methyl-CpG-binding protein 2.
Gerarda Cappuccio +6 more
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