Results 11 to 20 of about 9,200 (222)

Metabolomic Analysis of Phytophthora parasitica Growth in the Presence of β-sitosterol Indicates Adaptive Mechanisms Modulated by Sterols. [PDF]

J Basic Microbiol
ABSTRACT Phytophthora parasitica is a generalist phytopathogenic oomycete that infects a series of crops with great economic interest, including tomato, tobacco, and citrus species. Sterols are essential lipids in eukaryotic organisms, playing a fundamental role in the structure and function of the cell membrane.
Martins PP, Silva E, Prior MVF, Ferreira JMM, Santos MEP, Patrício FRA, Fill TP, Mondego JMC.   +7 more
europepmc   +2 more sources

Trifunctional Sphinganine: A New Tool to Dissect Sphingolipid Function

ACS Chemical Biology, 2023
ABSTRACTFunctions of the sphingolipids sphingosine and sphinganine in cells are not well established. While some signaling roles for sphingosine have been elucidated, the closely related sphinganine has been described only insofar as it does not elicit many of the same signaling responses.
Scotland Farley, Frank Stein, Per Haberkant, Fikadu G. Tafesse, Carsten Schultz   +4 more
openaire   +2 more sources

Metabolic Characterization of the Common Marmoset (Callithrix jacchus) [PDF]

, 2015
High-resolution metabolomics has created opportunity to integrate nutrition and metabolism into genetic studies to improve understanding of the diverse radiation of primate species.
Go, Young-Mi, Jones, Dean P., Liang, Yongliang, Promislow, Daniel E. L., Soltow, Quinlyn A., Uppal, Karan, Wachtman, Lynn M.   +6 more
core   +11 more sources

Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis. [PDF]

, 2015
Palmitic acid (PA) induces hepatocyte apoptosis and fuels de novo ceramide synthesis in the endoplasmic reticulum (ER). Myristic acid (MA), a free fatty acid highly abundant in copra/palmist oils, is a predictor of nonalcoholic steatohepatitis (NASH) and
Alarcón-Vila, C, Baulies, A, Caballeria, J, Casas, J, Elena, M, Fabriàs, G, Fernandez-Checa, JC, García-Ruiz, C, Martinez Gili, L, Torres, S   +9 more
core   +2 more sources

Conversion of erythro-D-sphinganine to its [1-2H1] and [1-3H1] derivatives.

Journal of Lipid Research, 1984
A convenient chemical synthesis of erythro-D-[1-2H1] sphinganine and erythro-D-[1-3H1]sphinganine is described. The approach utilizes a stereospecific starting material (natural sphinganine prepared from bovine brain sphingomyelin) and applies a sequence
M W Crossman, C B Hirschberg
doaj   +1 more source

The low intestinal and hepatic toxicity of hydrolyzed fumonisin B1 correlates with its inability to alter the metabolism of sphingolipids [PDF]

, 2012
Fumonisins are mycotoxins frequently found as natural contaminants in maize, where they are produced by the plant pathogen Fusarium verticillioides. They are toxic to animals and exert their effects through mechanisms involving disruption of sphingolipid
Bracarense, Ana-Paula, Cossalter, Anne-Marie, Grenier, Bertrand, Kolf-Clauw, Martine, Moll, Wulf-Dieter, Oswald, Isabelle P, Schatzmayr, Gerd, Schwartz, Heidi-Elisabeth, Trumel, Catherine   +8 more
core   +2 more sources

Preparation of anti-vicinal amino alcohols: asymmetric synthesis of D-erythro-Sphinganine, (+)-spisulosine and D-ribo-phytosphingosine [PDF]

, 2013
Two variations of the Overman rearrangement have been developed for the highly selective synthesis of anti-vicinal amino alcohol natural products. A MOM-ether directed palladium(II)-catalyzed rearrangement of an allylic trichloroacetimidate was used as ...
Abraham E., Ahmed M. Zaed, Ait-Youcef R., Allepuz A. C., Amarante G. W., Andrew Sutherland, Barrett A. G. M., Bernet B., Blanchette M. A., Cai Y., Cai Y., Chen B.-S., Cook G. R., Corey E. J., Corey E. J., Cuadros R., Davies S. G., Devi T. J., Dickson R. C., Dinda S. K., Enders D., Ewen D. D. Calder, Fanning K. N., Fernandes R. A., Ghosal P., Hertweck C., Hoffmann R. W., Howell A. R., Hubieki M. P., Jamieson A. G., Jamieson A. G., Jamieson A. G., Jamieson A. G., Kokatla H. P., Kolb H. C., Kolter T., Koskinen P. M., Lee S. I., Lipshutz B. H., Liu Z., Llaveria J., Lombardo M., Luo S.-Y., Malik G., Martinková M., Modrak D. E., Morales-Serna J. A., Murakami T., Naidu S. V., Ndakala A. J., Ndonye R. M., Perali R. S., Prabhakar P., Rodriguez-Lafrasse C., Schneiter R., Sengupta S., Snook C. F., So R. C., Summers S. A., Swift M. D., Séguin C., Watanabe M., Xarnod C., Xu K., Yoon H. J., Yun J. M., Zaed A., Zaed A. M.   +67 more
core   +1 more source

Gas-liquid chromatography-mass spectrometry of synthetic ceramides

Journal of Lipid Research, 1969
Two series of ceramides with either sphingosine (sphing-4-enine) or sphinganine as base and with one of the saturated fatty acids C16, C18, C20, C22, C24, C26, or oleic acid were analyzed as the 1,3-di-O-trimethylsilyl ether derivatives by gas ...
Bengt Samuelsson, Karin Samuelsson
doaj   +1 more source

Specialized acyl carrier protein used by serine palmitoyltransferase to synthesize sphingolipids in Rhodobacteria

Frontiers in Microbiology, 2022
Serine palmitoyltransferase (SPT) catalyzes the first and committed step in sphingolipid biosynthesis condensating L-serine and acyl-CoA to form 3-oxo-sphinganine. Whenever the structural gene for SPT is present in genomes of Rhodobacteria (α-, β-, and γ-
Jonathan Padilla-Gómez, Roberto Jhonatan Olea-Ozuna, Sandra Contreras-Martínez, Orlando Morales-Tarré, Daniela A. García-Soriano, Diana X. Sahonero-Canavesi, Sebastian Poggio, Sergio Encarnación-Guevara, Isabel M. López-Lara, Otto Geiger   +9 more
doaj   +1 more source

Feeding Stimulates Sphingosine-1-Phosphate Mobilization in Mouse Hypothalamus. [PDF]

, 2019
Previous studies have shown that the sphingolipid-derived mediator sphingosine-1-phosphate (S1P) reduces food intake by activating G protein-coupled S1P receptor-1 (S1PR1) in the hypothalamus.
Misto, Alessandra, Piomelli, Daniele, Realini, Natalia, Vozella, Valentina   +3 more
core   +1 more source