Results 61 to 70 of about 57,421 (279)

Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets [PDF]

Journal of Lipid Research, 2005
The bioactive molecule sphingosine 1-phosphate (S1P) is abundantly stored in platelets and can be released extracellularly. However, although they have high sphingosine (Sph) kinase activity, platelets lack the de novo sphingolipid biosynthesis necessary to provide the substrates.
Motohiro Tani, Takamitsu Sano, Makoto Ito, Yasuyuki Igarashi   +3 more
openaire   +3 more sources

Functional Characterization of a Higher Plant Sphingolipid Δ4-Desaturase: Defining the Role of Sphingosine and Sphingosine-1-Phosphate in Arabidopsis

, 2008
The role of Δ4-unsaturated sphingolipid long-chain bases such as sphingosine was investigated in Arabidopsis (Arabidopsis thaliana). Identification and functional characterization of the sole Arabidopsis ortholog of the sphingolipid Δ4-desaturase was ...
Warnecke, D., Sperling, Petra, Haslam, Richard P., Mugford, S., Napier, Johnathan A., Sperling, P., Sarah Mugford, Albrecht, S., Johnathan A. Napier, Petra Sperling, Richard P. Haslam, Simone Zäuner, Michaelson, L. V., Desikan, R., Haslam, R. P., Sandra Albrecht, Radhika Desikan, Dirk Warnecke, Albrecht, Sandra, Markham, J. E., Heinz, E., Warnecke, Dirk, E. Heinz, Desikan, Radhika, Michaelson, Louise V., Louise V. Michaelson, Markham, Jennifer E., Zauner, S., Zäuner, Simone, Napier, J. A., Mugford, Sarah, Jennifer E. Markham   +31 more
core   +1 more source

PEPITEM Regulates the Synovial Microenvironment During Immune‐Mediated Inflammatory Arthritis to Limit Disease

Arthritis &Rheumatology, EarlyView.
Objective Here we investigate the status of the adiponectin–PEPITEM pathway in early, treatment naive rheumatoid arthritis (RA) and psoriatic arthritis (PsA) and the therapeutic efficacy of PEPITEM administration in preclinical models. Methods Peripheral blood was isolated from patients with clinical suspect arthralgia and suspected inflammatory ...
Mussarat Wahid, Samuel Kemble, Oladimeji Abudu, Anella Saviano, Christopher Mahony, Jonathan W. Lewis, Thomas A. Nicholson, Anna Schettino, Noemi Marigliano, Kathryn Frost, Jenefa Begum, Alyssa M. Urbanowski, Marion Limo, Rakesh Jha, Sandra Martinez Jarquin, Laleh Pezhman, Abbie E. A. Degan, Amy E. Anderson, Charlotte G. Smith, Armaiti Batki, Holly Adams, Francesco Caso, Raffaele Scarpa, Iain McInnes, Stefan Siebert, Arthur G. Pratt, Andrew Filer, Karim Raza, Adam P. Croft, Myriam Chimen, Felicity de Cogan, G. Ed Rainger, Asif J. Iqbal, Francesco Maione, Helen M. McGettrick   +34 more
wiley   +1 more source

Human urinary sulfatides in patients with sulfatidosis (metachromatic leukodystrophy)

Journal of Lipid Research, 1971
The excretion of sulfatides in human urine was studied. 24-hr urine collections were filtered. Urinary glycolipids were extracted from the filter paper and fractionated on diethylaminoethyl cellulose and silicic acid columns, and by thin-layer ...
MICHEL PHILIPPART, LOUIS SARLIEVE, COLETTE MEURANT, LASZLO MECHLER   +3 more
doaj   +1 more source

Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis

British Journal of Clinical Pharmacology, EarlyView.
Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley   +1 more source

Liposomal Circular Dichroism (L-CD) of Arenoyl Derivatives of Sphingolipids. Amplification of Cotton Effects in Ordered Lipid Bilayers

Marine Drugs, 2017
Liposomal circular dichroism (L-CD) of acyclic amino alcohols exhibit amplification of Cotton effects when measured in highly uniform, unilamellar liposomes.
Tadeusz F. Molinski, Caroline D. Broaddus, Brandon I. Morinaka   +2 more
doaj   +1 more source

Targeting the sphingosine kinase/sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases

, 2014
Chronic kidney diseases including glomerulonephritis are often accompanied by acute or chronic inflammation that leads to an increase in extracellular matrix (ECM) production and subsequent glomerulosclerosis.
Stephanie Schwalm, Josef Pfeilschifter, Pfeilschifter, Josef, Huwiler, Andrea, Andrea Huwiler, Schwalm, Stephanie   +5 more
core   +1 more source

Increased sphingosine-1-phosphate serum concentrations in subjects with periodontitis: a matter of inflammation [PDF]

, 2021
Purpose: Periodontitis is an inflammatory disease of the oral cavity with an alarmingly high prevalence within the adult population. The signaling lipid sphingosine-1-phosphate (S1P) plays a crucial role in inflammatory and immunomodulatory responses. In
Rauch, Bernhard H., Meisel, Peter, Völzke, Henry, Negnal, Josefine, Felix, Stephan B., Dörr, Marcus, Jedlitschky, Gabriele, Schwedhelm, Edzard, Daum, Günter, Tzvetkov, Mladen V., Kocher, Thomas, Nauck, Matthias, Moritz, Eileen, Holtfreter, Birte   +13 more
core  

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

The Role of Distinctive Sphingolipids in the Inflammatory and Apoptotic Effects of Electronegative LDL on Monocytes

Biomolecules, 2019
Electronegative low-density lipoprotein (LDL(−)) is a minor LDL subfraction that is present in blood with inflammatory and apoptotic effects.
Núria Puig, Montserrat Estruch, Lei Jin, Jose Luis Sanchez-Quesada, Sonia Benitez   +4 more
doaj   +1 more source