Results 61 to 70 of about 61,732 (250)
A novel mode of action of the putative sphingosine kinase inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole (SKI II): induction of lysosomal sphingosine kinase 1 degradation [PDF]
, 2010 Sphingosine kinase 1 (SK1) is a key enzyme in the generation of sphingosine 1-phosphate (S1P) which critically regulates a variety of important cell responses such as proliferation and migration.
Xin, Cuiyan +3 more
core +2 more sources
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Inflammatory bowel disease management has undergone a major transformation with the introduction of treat‐to‐target strategies and highly effective biologic and small‐molecule therapies. Although these advances have reduced the overall requirement for surgery, operative intervention remains essential for selected patients with ulcerative ...
Yoshiki Okita +4 more
wiley +1 more source
Human urinary sulfatides in patients with sulfatidosis (metachromatic leukodystrophy)
Journal of Lipid Research, 1971 The excretion of sulfatides in human urine was studied. 24-hr urine collections were filtered. Urinary glycolipids were extracted from the filter paper and fractionated on diethylaminoethyl cellulose and silicic acid columns, and by thin-layer ...
MICHEL PHILIPPART +3 more
doaj +1 more source
Marine Drugs, 2017 Liposomal circular dichroism (L-CD) of acyclic amino alcohols exhibit amplification of Cotton effects when measured in highly uniform, unilamellar liposomes.
Tadeusz F. Molinski +2 more
doaj +1 more source
Roles of sphingosine 1-phosphate on tumorigenesis
, 2011 [[abstract]]Roles of sphingosine 1-phosphate on ...
黃元勵;Huang, Yuan-Li, Yuan-Li Huang
core +1 more source
Biomolecules, 2019 Electronegative low-density lipoprotein (LDL(−)) is a minor LDL subfraction that is present in blood with inflammatory and apoptotic effects.
Núria Puig +4 more
doaj +1 more source
Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis
British Journal of Clinical Pharmacology, EarlyView.Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley +1 more source
Frontiers in Molecular BiosciencesIntroduction: Hexavalent chromium [Cr (VI)] has been identified as a human carcinogen and environmental pollutant capable of affecting multiple systems in the human body.
Hongge Tang +4 more
doaj +1 more source
New methods for determining the enantiomeric purity of erythro-sphingosine
Journal of Lipid Research, 1999 The enantiomeric purity of erythro-sphingosine samples can be determined simply, reliably, and accurately from 1H or 19F nuclear magnetic resonance spectra of the α-methoxy-α-(trifluoromethyl)phenylacetate (MTPA) derivative.
Shengrong Li +2 more
doaj +1 more source
Sphingolipids and Mitochondrial Dynamic
Cells, 2020 For decades, sphingolipids have been related to several biological functions such as immune system regulation, cell survival, and proliferation. Recently, it has been reported that sphingolipids could be biomarkers in cancer and in other human disorders ...
Lais Brigliadori Fugio +2 more
doaj +1 more source