Results 1 to 10 of about 19,584 (228)
Nature Communications, 2023 Systemic inflammation has been implicated in the pathobiology of heart failure with preserved ejection fraction (HFpEF). Here, we examine the association of upstream mediators of inflammation as ascertained by fatty-acid derived eicosanoid and eicosanoid-
Emily S. Lau +16 more
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Structural Manipulation of Eicosanoid Receptors and Cellular Signaling
The Scientific World Journal, 2007 Eicosanoids are lipid mediators derived from the metabolism of arachidonic acid. These agents are locally released and activate different cell membrane receptors, and the latter are part of the G-protein coupled receptor family.
Charles Brink
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Gut microbiota in chronic inflammation: the interplay with lipid mediators [PDF]
Gut MicrobesThe gut microbiota plays a fundamental role in maintaining host health by regulating immune function, epithelial barrier integrity, and metabolic homeostasis.
Suxia Bao, Chengcan Yao
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Eicosanoid release is increased by membrane destabilization and CFTR inhibition in Calu-3 cells. [PDF]
PLoS ONE, 2009 The antiinflammatory protein annexin-1 (ANXA1) and the adaptor S100A10 (p11), inhibit cytosolic phospholipase A2 (cPLA2alpha) by direct interaction. Since the latter is responsible for the cleavage of arachidonic acid at membrane phospholipids, all three
Florence Borot +12 more
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A genome-wide association study identifies 41 loci associated with eicosanoid levels
Communications Biology, 2023 Eicosanoids are biologically active derivatives of polyunsaturated fatty acids with broad relevance to health and disease. We report a genome-wide association study in 8406 participants of the Atherosclerosis Risk in Communities Study, identifying 41 ...
Eugene P. Rhee +9 more
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Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology1[S] [PDF]
Journal of Lipid Research, 2009 Eicosanoids have been implicated in a vast number of devastating inflammatory conditions, including arthritis, atherosclerosis, pain, and cancer. Currently, over a hundred different eicosanoids have been identified, with many having potent bioactive ...
Matthew W. Buczynski +2 more
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The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals [PDF]
Open MedicinePolyphenols are a group of compounds identified as secondary metabolites of plants, with 8,000 types identified to date. Previous research findings have indicated the potential anti-inflammatory properties of polyphenols, with studies suggesting a ...
Pantano Licia +12 more
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Essays in Biochemistry, 2020 Abstract This article describes the pathways of eicosanoid synthesis, eicosanoid receptors, the action of eicosanoids in different physiological systems, the roles of eicosanoids in selected diseases, and the major inhibitors of eicosanoid synthesis and action. Eicosanoids are oxidised derivatives of 20-carbon polyunsaturated fatty acids
Hammock, Bruce D. +3 more
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Eicosanoid regulation of debris-stimulated metastasis [PDF]
, 2021 Cancer therapy reduces tumor burden via tumor cell death ("debris"), which can accelerate tumor progression via the failure of inflammation resolution.
Hammock, Bruce D +15 more
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Frontiers in Physiology, 2023 Introduction: Eicosanoids are bioactive lipids present in packed red blood cells (PRBCs), and might play a role in transfusion-related immunomodulation (TRIM).
Pierre Raeven +11 more
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