Results 1 to 10 of about 21,372 (200)

Gut microbiota in chronic inflammation: the interplay with lipid mediators [PDF]

Gut Microbes
The gut microbiota plays a fundamental role in maintaining host health by regulating immune function, epithelial barrier integrity, and metabolic homeostasis.
Suxia Bao, Chengcan Yao
doaj   +2 more sources

Eicosanoid release is increased by membrane destabilization and CFTR inhibition in Calu-3 cells. [PDF]

PLoS ONE, 2009
The antiinflammatory protein annexin-1 (ANXA1) and the adaptor S100A10 (p11), inhibit cytosolic phospholipase A2 (cPLA2alpha) by direct interaction. Since the latter is responsible for the cleavage of arachidonic acid at membrane phospholipids, all three
Florence Borot, Diane-Lore Vieu, Grazyna Faure, Janine Fritsch, Julien Colas, Sandra Moriceau, Maryvonne Baudouin-Legros, Franck Brouillard, Jesus Ayala-Sanmartin, Lhousseine Touqui, Marc Chanson, Aleksander Edelman, Mario Ollero   +12 more
doaj   +2 more sources

Eicosanoid-Activated PPARα Inhibits NFκB-Dependent Bacterial Clearance During Post-Influenza Superinfection

Frontiers in Cellular and Infection Microbiology, 2022
Secondary bacterial infection (superinfection) post influenza is a serious clinical complication often leading to pneumonia and death. Eicosanoids are bioactive lipid mediators that play critical roles in the induction and resolution of inflammation ...
Ronald Lucarelli, Jessica Taddeo, Joris Beld   +2 more
exaly   +3 more sources

Red blood cell transfusion-related eicosanoid profiles in intensive care patients—A prospective, observational feasibility study

Frontiers in Physiology, 2023
Introduction: Eicosanoids are bioactive lipids present in packed red blood cells (PRBCs), and might play a role in transfusion-related immunomodulation (TRIM).
Pierre Raeven, Gerhard Hagn, Laura Niederstaetter, Jonas Brugger, Sophia Bayer-Blauensteiner, Christoph Domenig, Konrad Hoetzenecker, Martin Posch, Gerda Leitner, Christopher Gerner, Christopher Gerner, David M. Baron   +11 more
doaj   +1 more source

Deciphering Complex Interactions in Bioactive Lipid Signaling

Molecules, 2023
Lipids are usually viewed as metabolic fuel and structural membrane components. Yet, in recent years, different families of lipids able to act as authentic messengers between cells and/or intracellularly have been discovered. Such lipid signals have been
Mauro Maccarrone
doaj   +1 more source

Dorsal switch protein 1 as a damage signal in insect gut immunity to activate dual oxidase via an eicosanoid, PGE2

Frontiers in Immunology, 2022
Various microbiota including beneficial symbionts reside in the insect gut. Infections of pathogens cause dysregulation of the microflora and threaten insect survival. Reactive oxygen species (ROS) have been used in the gut immune responses, in which its
Miltan Chandra Roy, Shabbir Ahmed, Yonggyun Kim   +2 more
doaj   +1 more source

Plasma Oxylipins and Their Precursors Are Strongly Associated with COVID-19 Severity and with Immune Response Markers

Metabolites, 2022
COVID-19 is characterised by a dysregulated immune response, that involves signalling lipids acting as mediators of the inflammatory process along the innate and adaptive phases.
Naama Karu, Alida Kindt, Lieke Lamont, Adriaan J. van Gammeren, Anton A. M. Ermens, Amy C. Harms, Lutzen Portengen, Roel C. H. Vermeulen, Willem A. Dik, Anton W. Langerak, Vincent H. J. van der Velden, Thomas Hankemeier   +11 more
doaj   +1 more source

Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinase[S]

Journal of Lipid Research, 2013
Multiple reports have demonstrated a role for ceramide kinase (CERK) in the production of eicosanoids. To examine the effects of the genetic ablation of CERK on eicosanoid synthesis, primary mouse embryonic fibroblasts (MEFs) and macrophages were ...
Jennifer A. Mietla, Dayanjan S. Wijesinghe, L. Alexis Hoeferlin, Michael D. Shultz, Ramesh Natarajan, Alpha A. Fowler, III, Charles E. Chalfant   +6 more
doaj   +1 more source

FADS2 function loss at the cancer hotspot 11q13 locus diverts lipid signaling precursor synthesis to unusual eicosanoid fatty acids. [PDF]

PLoS ONE, 2011
BACKGROUND: Genes coding for the fatty acid desaturases (FADS1, 2, 3) localized at the cancer genomic hotspot 11q13 locus are required for the biosynthesis of 20 carbon polyunsaturated fatty acids (PUFA) that are direct eicosanoid precursors.
Woo Jung Park, Kumar S D Kothapalli, Peter Lawrence, J Thomas Brenna   +3 more
doaj   +1 more source

Prostanoid Metabolites as Biomarkers in Human Disease

Metabolites, 2022
Prostaglandins (PGD2, PGE2, PGF2α), prostacyclin (PGI2), and thromboxane A2 (TXA2) together form the prostanoid family of lipid mediators. As autacoids, these five primary prostanoids propagate intercellular signals and are involved in many physiological
Helena Idborg, Sven-Christian Pawelzik
doaj   +1 more source