Results 41 to 50 of about 21,935 (239)

Eicosanoid synthesis and T_H2 polarization.

, 2016
Eicosanoid synthesis and TH2 polarization.
George R. Smoliga (415772), Robert W. Li (164580), Michael Eschbaumer (249786), Luis L. Rodriguez (358559), James Zhu (3126924), Juan M. Pacheco (415773), Jonathan Arzt (415770), Carolina Stenfeldt (625352)   +7 more
core   +1 more source

Role of Oxylipins in the Inflammatory-Related Diseases NAFLD, Obesity, and Type 2 Diabetes

Metabolites, 2022
Oxygenated polyunsaturated fatty acids (oxylipins) are bioactive molecules established as important mediators during inflammation. Different classes of oxylipins have been found to have opposite effects, e.g., pro-inflammatory prostaglandins and anti ...
Mariya Misheva, Jethro Johnson, James McCullagh   +2 more
doaj   +1 more source

Early‐Life Polyethylene Microplastic Exposure Exacerbates ADHD‐Like Behaviors in Mice via PI3K/AKT1/Nrf2 Signaling: Evidence From the Pilot Cohort and Multi‐Omics Analyses

Advanced Science, EarlyView.
Circulating polyethylene microplastic burden is positively associated with heightened ADHD symptom severity and systemic redox‐inflammatory imbalance in children. Mechanistic investigation in a developmental co‐exposure mouse model further demonstrates that microplastics aggravate ADHD‐like behaviors, dopaminergic dysregulation, and oxidative ...
Yufan Luo, Ruijin Xie, Hua Xu, Xue Xiao, Wei Xiao, Qiyang Pan, Shengjie Xu, Li Liu, Zeliang Xiao, Yue Zhou, Chenyu Sun, Yu Wu, Yueying Liu   +12 more
wiley   +1 more source

PGE2 release is independent of upregulation of Group V phospholipase A2 during long-term stimulation of P388D1 cells with LPS1

Journal of Lipid Research, 2005
P388D1 cells release arachidonic acid (AA) and produce prostaglandin E2 (PGE2) upon long-term stimulation with lipopolysaccharide (LPS). The cytosolic Group IVA (GIVA) phospholipase A2 (PLA2) has been implicated in this pathway.
Ursula A. Kessen, Ralph H. Schaloske, Daren L. Stephens, Karin Killermann Lucas, Edward A. Dennis   +4 more
doaj   +1 more source

Selenomethionine Regulates the Arachidonic Acid Metabolism‐Ferroptosis‐Inflammation Axis to Ameliorate Colitis

Animal Research and One Health, EarlyView.
Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian, Longzhu Zhou, Xiaohui Feng, Jialu Shen, Xiaoping Du, Qingyu Zhao, Yuchang Qin, Junmin Zhang, Chaohua Tang   +8 more
wiley   +1 more source

Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions1,2[S]

Journal of Lipid Research, 2018
Two prostaglandin (PG) H synthases encoded by Ptgs genes, colloquially known as cyclooxygenase (COX)-1 and COX-2, catalyze the formation of PG endoperoxide H2, the precursor of the major prostanoids.
Xinzhi Li, Liudmila L. Mazaleuskaya, Chong Yuan, Laurel L. Ballantyne, Hu Meng, William L. Smith, Garret A. FitzGerald, Colin D. Funk   +7 more
doaj   +1 more source

Integration of Nutrition and Organic Agriculture Framework in Managing Gastrointestinal Nematodes in Ruminants

Animal Research and One Health, EarlyView.
Gastrointestinal nematode infections damage the gastrointestinal epithelial tissues of ruminants, affecting nutrient utilization and overall production performance. This review outlines host‐gastrointestinal nematode interactions and discusses integrated control strategies, including nutritional supplementation, grazing management, vaccines, and ...
Wenxun Chen, Xiangfang Tang, Yimin Zhuang, Shengjun Zhao, Ying Ren, Xiaokang Lv   +5 more
wiley   +1 more source

Initial values of the arachidonic acid/eicosanoid metabolic model.

, 2014
Initial values of the arachidonic acid/eicosanoid metabolic model.
Vikash Pandey (188392), Julia Starmann (303348), Michael Trauner (124235), Holger Sültmann (214717), Helmut Denk (649546), Kurt Zatloukal (234954), Vyacheslav Amstislavskiy (649544), Christoph Wierling (188401), Meryem Ralser (649543), Hendrik Hache (419872), Karl Kashofer (429432), Ingrid Osprian (649545), Marc Sultan (33002), Hans Lehrach (4881), Marie-Laure Yaspo (19028), Christina Grimm (280266)   +15 more
core   +1 more source

Genomic and lipidomic analyses differentiate the compensatory roles of two COX isoforms during systemic inflammation in mice1,2[S]

Journal of Lipid Research, 2018
Both cyclooxygenase (COX)-1 and COX-2, encoded by Ptgs1 and Ptgs2, function coordinately during inflammation. But the relative contributions and compensations of COX-1 and COX-2 to inflammatory responses remain unanswered.
Xinzhi Li, Liudmila L. Mazaleuskaya, Laurel L. Ballantyne, Hu Meng, Garret A. FitzGerald, Colin D. Funk   +5 more
doaj   +1 more source

Eicosanoid-Activated PPARα Inhibits NFκB-Dependent Bacterial Clearance During Post-Influenza Superinfection

Frontiers in Cellular and Infection Microbiology, 2022
Secondary bacterial infection (superinfection) post influenza is a serious clinical complication often leading to pneumonia and death. Eicosanoids are bioactive lipid mediators that play critical roles in the induction and resolution of inflammation ...
Ronald Lucarelli, Norma Gorrochotegui-Escalante, Jessica Taddeo, Bettina Buttaro, Bettina Buttaro, Joris Beld, Vincent Tam   +6 more
doaj   +1 more source