Results 21 to 30 of about 21,372 (200)

A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster.

PLoS ONE, 2019
This study reports on a putative eicosanoid biosynthesis pathway in Drosophila melanogaster and challenges the currently held view that mechanistic routes to synthesize eicosanoid or eicosanoid-like biolipids do not exist in insects, since to date ...
Michael Scarpati, Yan Qi, Shubha Govind, Shaneen Singh   +3 more
doaj   +1 more source

Evidence that the E2-isoprostane, 15-E2t-isoprostane (8-iso-prostaglandin E2) is formed in vivo

Journal of Lipid Research, 1998
D2/E2-isoprostanes are prostaglandin D2/E2-like compounds that are produced in vivo as non-enzymatic products of free radical catalyzed peroxidation of arachidonic acid.
Jason D. Morrow, Jennifer Scruggs, Yan Chen, William E. Zackert, L. Jackson Roberts, II   +4 more
doaj   +1 more source

The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells

, 2008
Activated mast cells are a major source of the eicosanoids PGD(2) and leukotriene C(4) (LTC(4)), which contribute to allergic responses. These eicosanoids are produced following the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus ...
Gilfillan, Alasdair M., Kuehn, Hye Sun, Beaven, Michael A., Swindle, Emily J., Kim, Mi-Sun, Metcalfe, Dean D.   +5 more
core   +2 more sources

Influence of dietary linoleic acid intake with different fat intakes on arachidonic acid concentrations in plasma and platelet lipids and eicosanoid biosynthesis in female volunteers [PDF]

, 2003
Background/Aim: N-6 fatty acids are considered to promote diseases prevalent in industrialized countries and characterized by an increased eicosanoid biosynthesis from arachidonic acid (AA).
Zöllner, N., Adam, Olaf, Wolfram, G.
core   +1 more source

Chronic dietary n-6 PUFA deprivation leads to conservation of arachidonic acid and more rapid loss of DHA in rat brain phospholipids[S]

Journal of Lipid Research, 2015
To determine how the level of dietary n-6 PUFA affects the rate of loss of arachidonic acid (ARA) and DHA in brain phospholipids, male rats were fed either a deprived or adequate n-6 PUFA diet for 15 weeks postweaning, and then subjected to an ...
Lauren E. Lin, Chuck T. Chen, Kayla D. Hildebrand, Zhen Liu, Kathryn E. Hopperton, Richard P. Bazinet   +5 more
doaj   +1 more source

Salicylic Acid, a Plant Hormone, Suppresses Phytophagous Insect Immune Response by Interrupting HMG-Like DSP1

Frontiers in Physiology, 2021
Salicylic acid is a plant hormone that can mediate various plant physiological processes. Salicylic acid can bind to human high mobility group box 1 (HMGB1) and interrupt its role in mediating immune responses. Dorsal switch protein 1 (DSP1) is an insect
Md. Mahi Imam Mollah, Hyong Woo Choi, Inhwa Yeam, Je Min Lee, Yonggyun Kim   +4 more
doaj   +1 more source

Immunoregulatory and anti-inflammatory effects of n-3 polyunsaturated fatty acids

Brazilian Journal of Medical and Biological Research, 1998
1. Fish oils are rich in the long-chain n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic (20:5n-3) and docosahexaenoic (22:6n-3) acids. Linseed oil and green plant tissues are rich in the precursor fatty acid, a-linolenic acid (18:3n-3).
P.C. Calder
doaj   +1 more source

Investigation of the Association between High Arachidonic Acid Synthesis and Colorectal Polyp Incidence within a Generally Healthy UK Population: A Mendelian Randomization Approach

Lifestyle Genomics, 2022
Background: Arachidonic acid (ARA) is associated with colorectal cancer (CRC), a major public health concern. However, it is uncertain if ARA contributes to the development of colorectal polyps which are pre-malignant precursors of CRC.
Rachel Moon, J. Bernadette Moore, Mark A. Hull, Michael A. Zulyniak   +3 more
doaj   +1 more source

Endothelin and eicosanoid synthesis in cultured mesangial cells [PDF]

, 1990
Endothelin and eicosanoid synthesis in cultured mesangial cells. We investigated the effect of endothelin on the generation of eicosanoids, which are known to regulate basal and stimulated mesangial cell tone.
Remuzzi, Giuseppe, Benigni, Ariela, Renzi, Daniela, Perico, Norberto, Zoja, Carla, Piccinelli, Antonella   +5 more
core   +1 more source

GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolism. [PDF]

, 2020
Metaflammation is a primary inflammatory complication of metabolic disorders characterized by altered production of many inflammatory cytokines, adipokines, and lipid mediators.
Sang, Yongjuan, Chong, Danyang, Zhao, Wei, Zheng, Yan-Yan, Jiang, Zhihui, Tao, Tao, Li, Yeqiong, Zhou, Yuwei, Sun, Jie, Chen, Xin, Wang, Ye, Qiu, Tiantian, Zhang, Xuena, Zhu, Min-Sheng, Li, Chao-Jun, Wang, Pei, Wei, Lisha   +16 more
core   +1 more source