Results 21 to 30 of about 21,935 (239)

Eicosanoids and cancer [PDF]

Nature Reviews Cancer, 2010
Eicosanoids, including prostaglandins and leukotrienes, are biologically active lipids that have been implicated in various pathological processes, such as inflammation and cancer. This Review highlights our understanding of the intricate roles of eicosanoids in epithelial-derived tumours and their microenvironment.
Dingzhi, Wang, Raymond N, Dubois
openaire   +2 more sources

Evidence that the E2-isoprostane, 15-E2t-isoprostane (8-iso-prostaglandin E2) is formed in vivo

Journal of Lipid Research, 1998
D2/E2-isoprostanes are prostaglandin D2/E2-like compounds that are produced in vivo as non-enzymatic products of free radical catalyzed peroxidation of arachidonic acid.
Jason D. Morrow, Jennifer Scruggs, Yan Chen, William E. Zackert, L. Jackson Roberts, II   +4 more
doaj   +1 more source

Chronic dietary n-6 PUFA deprivation leads to conservation of arachidonic acid and more rapid loss of DHA in rat brain phospholipids[S]

Journal of Lipid Research, 2015
To determine how the level of dietary n-6 PUFA affects the rate of loss of arachidonic acid (ARA) and DHA in brain phospholipids, male rats were fed either a deprived or adequate n-6 PUFA diet for 15 weeks postweaning, and then subjected to an ...
Lauren E. Lin, Chuck T. Chen, Kayla D. Hildebrand, Zhen Liu, Kathryn E. Hopperton, Richard P. Bazinet   +5 more
doaj   +1 more source

Salicylic Acid, a Plant Hormone, Suppresses Phytophagous Insect Immune Response by Interrupting HMG-Like DSP1

Frontiers in Physiology, 2021
Salicylic acid is a plant hormone that can mediate various plant physiological processes. Salicylic acid can bind to human high mobility group box 1 (HMGB1) and interrupt its role in mediating immune responses. Dorsal switch protein 1 (DSP1) is an insect
Md. Mahi Imam Mollah, Hyong Woo Choi, Inhwa Yeam, Je Min Lee, Yonggyun Kim   +4 more
doaj   +1 more source

The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells

, 2008
Activated mast cells are a major source of the eicosanoids PGD(2) and leukotriene C(4) (LTC(4)), which contribute to allergic responses. These eicosanoids are produced following the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus ...
Gilfillan, Alasdair M., Kuehn, Hye Sun, Beaven, Michael A., Swindle, Emily J., Kim, Mi-Sun, Metcalfe, Dean D.   +5 more
core   +2 more sources

Immunoregulatory and anti-inflammatory effects of n-3 polyunsaturated fatty acids

Brazilian Journal of Medical and Biological Research, 1998
1. Fish oils are rich in the long-chain n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic (20:5n-3) and docosahexaenoic (22:6n-3) acids. Linseed oil and green plant tissues are rich in the precursor fatty acid, a-linolenic acid (18:3n-3).
P.C. Calder
doaj   +1 more source

Eicosanoids and cancer

Clinics, 2018
Eicosanoids are 20-carbon bioactive lipids derived from the metabolism of polyunsaturated fatty acids, which can modulate various biological processes including cell proliferation, adhesion and migration, angiogenesis, vascular permeability and inflammatory responses.
Gomes, Renata Nascimento, Felipe da Costa, Souza, Colquhoun, Alison   +2 more
openaire   +5 more sources

Investigation of the Association between High Arachidonic Acid Synthesis and Colorectal Polyp Incidence within a Generally Healthy UK Population: A Mendelian Randomization Approach

Lifestyle Genomics, 2022
Background: Arachidonic acid (ARA) is associated with colorectal cancer (CRC), a major public health concern. However, it is uncertain if ARA contributes to the development of colorectal polyps which are pre-malignant precursors of CRC.
Rachel Moon, J. Bernadette Moore, Mark A. Hull, Michael A. Zulyniak   +3 more
doaj   +1 more source

Current Trends and Changes in Use of Membrane Molecular Dynamics Simulations within Academia and the Pharmaceutical Industry

Membranes, 2023
There has been an almost exponential increase in the use of molecular dynamics simulations in basic research and industry over the last 5 years, with almost a doubling in the number of publications each year.
Stephan L. Watkins
doaj   +1 more source

Candida albicans and Pseudomonas aeruginosa interaction, with focus on the role of eicosanoids

Frontiers in Physiology, 2016
Candida albicans is commonly found in mixed infections with Pseudomonas aeruginosa, especially in the lungs of cystic fibrosis patients. Both of these opportunistic pathogens are able to form resistant biofilms and frequently infect immunocompromised ...
Ruan eFourie, Ruan eElls, Ruan eElls, Chantel Wendy Swart, Olihile M Sebolai, Jacobus eAlbertyn, Carolina Henritta Pohl   +6 more
doaj   +1 more source