Results 11 to 20 of about 21,935 (239)

Eicosanoid and eicosanoid-related inflammatory mediators and exercise intolerance in heart failure with preserved ejection fraction [PDF]

Nature Communications, 2023
Systemic inflammation has been implicated in the pathobiology of heart failure with preserved ejection fraction (HFpEF). Here, we examine the association of upstream mediators of inflammation as ascertained by fatty-acid derived eicosanoid and eicosanoid-
Emily S. Lau, Athar Roshandelpoor, Shahrooz Zarbafian, Dongyu Wang, James S. Guseh, Norrina Allen, Vinithra Varadarajan, Matthew Nayor, Ravi V. Shah, Joao A. C. Lima, Sanjiv J. Shah, Bing Yu, Mona Alotaibi, Susan Cheng, Mohit Jain, Gregory D. Lewis, Jennifer E. Ho   +16 more
doaj   +2 more sources

Nuciferine Suppresses Inflammatory Hepatocarcinogenesis by Targeting cPLA2‐Dependent Arachidonic Acid Metabolism [PDF]

Advanced science
Nuciferine directly binds the C2 domain of cPLA2, impairing its Ca2+‐dependent membrane translocation and activation. By suppressing arachidonic acid release and downstream pro‐inflammatory eicosanoid production, nuciferine attenuates NF‐κB signaling and inflammatory hepatocarcinogenesis, revealing cPLA2 as a direct molecular target underlying its ...
Sun J, Wu X, Luo S, Liu Y, Liu J, Lu J, Wang W, Feng X, Zhang T, Panigrahy D, Deng J, Liao X, Yang H.   +12 more
europepmc   +2 more sources

Structural Manipulation of Eicosanoid Receptors and Cellular Signaling

The Scientific World Journal, 2007
Eicosanoids are lipid mediators derived from the metabolism of arachidonic acid. These agents are locally released and activate different cell membrane receptors, and the latter are part of the G-protein coupled receptor family.
Charles Brink
doaj   +2 more sources

Gut microbiota in chronic inflammation: the interplay with lipid mediators [PDF]

Gut Microbes
The gut microbiota plays a fundamental role in maintaining host health by regulating immune function, epithelial barrier integrity, and metabolic homeostasis.
Suxia Bao, Chengcan Yao
doaj   +2 more sources

A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster.

PLoS ONE, 2019
This study reports on a putative eicosanoid biosynthesis pathway in Drosophila melanogaster and challenges the currently held view that mechanistic routes to synthesize eicosanoid or eicosanoid-like biolipids do not exist in insects, since to date ...
Michael Scarpati, Yan Qi, Shubha Govind, Shaneen Singh   +3 more
doaj   +2 more sources

Eicosanoids [PDF]

Essays in Biochemistry, 2020
Abstract This article describes the pathways of eicosanoid synthesis, eicosanoid receptors, the action of eicosanoids in different physiological systems, the roles of eicosanoids in selected diseases, and the major inhibitors of eicosanoid synthesis and action. Eicosanoids are oxidised derivatives of 20-carbon polyunsaturated fatty acids
Hammock, Bruce D., Wang, Weicang, Gilligan, Molly M., Panigrahy, Dipak   +3 more
  +10 more sources

Eicosanoid regulation of debris-stimulated metastasis [PDF]

, 2021
Cancer therapy reduces tumor burden via tumor cell death ("debris"), which can accelerate tumor progression via the failure of inflammation resolution.
Hammock, Bruce D, Yang, Jun, Panigrahy, Dipak, Hwang, Sung Hee, Deng, Jianjun, Gartung, Allison, Barksdale, Chantal, Yang, Haixia, Kipper, Franciele C, Ho, Koc-Kan, Fan, Daidi, Haak, Victoria M, Sun, Yongkui, Bielenberg, Diane R, Subbian, Selvakumar, Ye, Xiang, Haixia Yang, Dipak Panigrahy, Chantal Barksdale, Jun Yang, Selvakumar Subbian, Diane R. Bielenberg, Bruce D. Hammock, Jianjun Deng, Xiang Ye, Sung Hee Hwang, Yongkui Sun, Franciele C. Kipper, Daidi Fan, Allison Gartung, Victoria M. Haak, Koc-Kan Ho   +31 more
core   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Anopheles gambiae eicosanoids modulate Plasmodium berghei survival from oocyst to salivary gland invasion

Memorias do Instituto Oswaldo Cruz, 2014
Eicosanoids affect the immunity of several pathogen/insect models, but their role on the Anopheles gambiae response to Plasmodium is still unknown.
Susana Ramos, Ana Custódio, Henrique Silveira   +2 more
doaj   +1 more source

Pleiotropic Functions of Cytochrome P450 Monooxygenase-Derived Eicosanoids in Cancer

Frontiers in Pharmacology, 2020
Eicosanoids are a class of functionally bioactive lipid mediators derived from the metabolism of long-chain polyunsaturated fatty acids (PUFAs) mediated by multiple enzymes of three main branches, including cyclooxygenases (COXs), lipoxygenases (LOXs ...
Ying Luo, Jun-Yan Liu
doaj   +1 more source