Results 11 to 20 of about 21,372 (200)

Eicosanoid and eicosanoid-related inflammatory mediators and exercise intolerance in heart failure with preserved ejection fraction [PDF]

Nature Communications, 2023
Systemic inflammation has been implicated in the pathobiology of heart failure with preserved ejection fraction (HFpEF). Here, we examine the association of upstream mediators of inflammation as ascertained by fatty-acid derived eicosanoid and eicosanoid-
Emily S. Lau, Athar Roshandelpoor, Shahrooz Zarbafian, Dongyu Wang, James S. Guseh, Norrina Allen, Vinithra Varadarajan, Matthew Nayor, Ravi V. Shah, Joao A. C. Lima, Sanjiv J. Shah, Bing Yu, Mona Alotaibi, Susan Cheng, Mohit Jain, Gregory D. Lewis, Jennifer E. Ho   +16 more
doaj   +2 more sources

Structural Manipulation of Eicosanoid Receptors and Cellular Signaling

The Scientific World Journal, 2007
Eicosanoids are lipid mediators derived from the metabolism of arachidonic acid. These agents are locally released and activate different cell membrane receptors, and the latter are part of the G-protein coupled receptor family.
Charles Brink
doaj   +2 more sources

A genome-wide association study identifies 41 loci associated with eicosanoid levels [PDF]

Communications Biology, 2023
Eicosanoids are biologically active derivatives of polyunsaturated fatty acids with broad relevance to health and disease. We report a genome-wide association study in 8406 participants of the Atherosclerosis Risk in Communities Study, identifying 41 ...
Eugene P. Rhee, Aditya L. Surapaneni, Pascal Schlosser, Mona Alotaibi, Yueh-ning Yang, Josef Coresh, Mohit Jain, Susan Cheng, Bing Yu, Morgan E. Grams   +9 more
doaj   +2 more sources

Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology1[S] [PDF]

Journal of Lipid Research, 2009
Eicosanoids have been implicated in a vast number of devastating inflammatory conditions, including arthritis, atherosclerosis, pain, and cancer. Currently, over a hundred different eicosanoids have been identified, with many having potent bioactive ...
Matthew W. Buczynski, Darren S. Dumlao, Edward A. Dennis   +2 more
doaj   +2 more sources

Eicosanoid regulation of debris-stimulated metastasis [PDF]

, 2021
Cancer therapy reduces tumor burden via tumor cell death ("debris"), which can accelerate tumor progression via the failure of inflammation resolution.
Hammock, Bruce D, Yang, Jun, Panigrahy, Dipak, Hwang, Sung Hee, Deng, Jianjun, Gartung, Allison, Barksdale, Chantal, Yang, Haixia, Kipper, Franciele C, Ho, Koc-Kan, Fan, Daidi, Haak, Victoria M, Sun, Yongkui, Bielenberg, Diane R, Subbian, Selvakumar, Ye, Xiang   +15 more
core   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Multi-omics analysis reveals insights into the differentiation between radiological subtypes of early lung adenocarcinoma. [PDF]

Clin Transl Med
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Miao H, Kong R, Xu X, Wang M, Teng X, Zhu D, Zhao W, Cai S, Zhou J, Lv X, Zhou Z.   +10 more
europepmc   +2 more sources

Marked elevations in pro-inflammatory polyunsaturated fatty acid metabolites in females with irritable bowel syndrome

Journal of Lipid Research, 2010
Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder referred to gastroenterologists. Although the pathophysiology remains unclear, accumulating evidence points to the presence of low-level immune activation both in the ...
Gerard Clarke, Peter Fitzgerald, Alan A. Hennessy, Eugene M. Cassidy, Eamonn M.M. Quigley, Paul Ross, Catherine Stanton, John F. Cryan, Timothy G. Dinan   +8 more
doaj   +1 more source

Anopheles gambiae eicosanoids modulate Plasmodium berghei survival from oocyst to salivary gland invasion

Memorias do Instituto Oswaldo Cruz, 2014
Eicosanoids affect the immunity of several pathogen/insect models, but their role on the Anopheles gambiae response to Plasmodium is still unknown.
Susana Ramos, Ana Custódio, Henrique Silveira   +2 more
doaj   +1 more source

Pleiotropic Functions of Cytochrome P450 Monooxygenase-Derived Eicosanoids in Cancer

Frontiers in Pharmacology, 2020
Eicosanoids are a class of functionally bioactive lipid mediators derived from the metabolism of long-chain polyunsaturated fatty acids (PUFAs) mediated by multiple enzymes of three main branches, including cyclooxygenases (COXs), lipoxygenases (LOXs ...
Ying Luo, Jun-Yan Liu
doaj   +1 more source