Results 1 to 10 of about 9,479 (223)

Genome-wide analysis of oxylipins and oxylipin profiles in a pediatric population

Frontiers in Nutrition, 2023
BackgroundOxylipins are inflammatory biomarkers derived from omega-3 and-6 fatty acids implicated in inflammatory diseases but have not been studied in a genome-wide association study (GWAS).
Teresa Buckner, Teresa Buckner, Randi K. Johnson, Randi K. Johnson, Lauren A. Vanderlinden, Patrick M. Carry, Patrick M. Carry, Alex Romero, Suna Onengut-Gumuscu, Wei-Min Chen, Soojeong Kim, Oliver Fiehn, Brigitte I. Frohnert, Tessa Crume, Wei Perng, Katerina Kechris, Marian Rewers, Jill M. Norris   +17 more
doaj   +5 more sources

Oxylipin composition of high-density lipoprotein is altered in men and Hispanic adults with mild cognitive impairment [PDF]

Journal of Lipid Research
High-density lipoprotein (HDL) oxylipins are potent inflammatory mediators. HDL dyshomeostasis and inflammation increase mild cognitive impairment (MCI) and dementia risk, which vary by gender and race/ethnicity.
Julia C. Kelliher, Christopher G. Engeland, Jennifer E. Graham-Engeland, Mindy Katz, Claudette Kessler, Gregory C. Shearer   +5 more
doaj   +2 more sources

Comprehensive Analysis of Different Subtypes of Oxylipins to Determine a LC–MS/MS Approach in Clinical Research [PDF]

Metabolites
Background/Objectives: Different oxylipin subtypes have unique biological properties, requiring effective analytical protocols. However, establishing a complete pathway detection protocol for comprehensive oxylipin analysis is challenging.
Yurou Zhao, Zhengyu Fang, Zeyu Li, Yizhe Liu, Yang Bai, Xiaoqing Wang, Hongjun Yang, Na Guo   +7 more
doaj   +2 more sources

Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation

Nature Communications, 2022
Oxylipins are lipid mediators generated during infection for regulating inflammatory responses, but how they are removed is not completely clear. Here the authors show that cellular oxylipin removal is linked to mitochondria β-oxidation by CPT1, a ...
Konstantinos Kotzamanis, Luke C Davies, Patricia R S Rodrigues   +2 more
exaly   +2 more sources

The Patatin-Containing Phospholipase A pPLAIIα Modulates Oxylipin Formation and Water Loss in Arabidopsis thaliana [PDF]

Molecular Plant, 2012
The patatin-related phospholipase A (pPLA) hydrolyzes membrane glycerolipids to produce monoacyl compounds and free fatty acids. Phospholipids are cleaved by pPLAIIα at the sn-1 and sn-2 positions, and galactolipids, including those containing ...
Yong Zheng, Hieu Sy Vu, Mary Roth
exaly   +3 more sources

Oxylipin Profiling of Alzheimer’s Disease in Nondiabetic and Type 2 Diabetic Elderly

Metabolites, 2019
Oxygenated lipids, called “oxylipins,” serve a variety of important signaling roles within the cell. Oxylipins have been linked to inflammation and vascular function, and blood patterns have been shown to differ in type 2 diabetes (T2D ...
Jill K Morris, Brian D Piccolo, John P Thyfault   +2 more
exaly   +3 more sources

Workflow for the Isolation and Characterisation of Human Milk Extracellular Vesicles (HMEVs) and Their Inflammatory Biomarker Profile [PDF]

Journal of Extracellular Biology
Human milk extracellular vesicles (HMEVs), secreted by mammary epithelial cells, are enriched in bioactive molecules that support intestinal epithelial integrity.
Jose Luis Moreno‐Casillas, Laura Ripoll‐Seguer, Isabel Ten‐Doménech, Marta Gómez‐Ferrer, Pilar Sepúlveda, Abel Albiach‐Delgado, Juan Daniel Sanjuan‐Herráez, María Gormaz, David Pérez‐Guaita, Bernhard Lendl, María Cernada, Guillermo Quintás, Julia Kuligowski   +12 more
doaj   +2 more sources

The polyunsaturated fatty acid and oxylipin plasma signature of aneurysmal subarachnoid haemorrhage, case-control study [PDF]

Neurotherapeutics
Delayed cerebral ischemia (DCI) following aneurysmal subarachnoid haemorrhage (aSAH) is a complex and acute condition with limited options for early detection and effective treatments.
M.A. Franssen, M.A. Tjerkstra, M. Heijink, S.A. Rotman, D. Verbaan, E. van Bavel, W.P. Vandertop, H.E. de Vries, J.M. Coutinho, M.A. Giera, I.A. Mulder, G. Kooij   +11 more
doaj   +2 more sources

Integrated analysis of whole blood oxylipin and cytokine responses after bacterial, viral, and T cell stimulation reveals new immune networks

iScience, 2023
Summary: Oxylipins are major immunomodulating mediators, yet studies of inflammation focus mainly on cytokines. Here, using a standardized whole-blood stimulation system, we characterized the oxylipin-driven inflammatory responses to various stimuli and ...
Etienne Villain, Aurélie Chanson, Malwina Mainka, Nadja Kampschulte, Pauline Le Faouder, Justine Bertrand-Michel, Marion Brandolini-Bulon, Bruno Charbit, Munyaradzi Musvosvi, Nicole Bilek, Thomas J. Scriba, Lluis Quintana-Murci, Nils Helge Schebb, Darragh Duffy, Cécile Gladine, Laurent Abel, Andres Alcover, Hugues Aschard, Philippe Bousso, Nollaig Bourke, Petter Brodin, Pierre Bruhns, Nadine Cerf-Bensussan, Ana Cumano, Christophe D’Enfert, Ludovic Deriano, Marie-Agnès Dillies, James Di Santo, Gérard Eberl, Jost Enninga, Jacques Fellay, Ivo Gomperts-Boneca, Milena Hasan, Gunilla Karlsson Hedestam, Serge Hercberg, Molly A. Ingersoll, Olivier Lantz, Rose Anne Kenny, Mickaël Ménager, Hugo Mouquet, Cliona O'Farrelly, Etienne Patin, Sandra Pellegrini, Antonio Rausell, Frédéric Rieux-Laucat, Lars Rogge, Magnus Fontes, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Frédéric Tangy, Antoine Toubert, Mathilde Touvier, Marie-Noëlle Ungeheuer, Christophe Zimmer, Matthew L. Albert, Darragh Duffy, Lluis Quintana-Murci   +58 more
doaj   +1 more source

Oxylipin secretion by human CD3+ T lymphocytes in vitro is modified by the exogenous essential fatty acid ratio and life stage

Frontiers in Immunology, 2023
Immune function changes across the life stages; for example, senior adults exhibit a tendency towards a weaker cell-mediated immune response and a stronger inflammatory response than younger adults.
Johanna von Gerichten, Annette L. West, Nicola A. Irvine, Elizabeth A. Miles, Philip C. Calder, Philip C. Calder, Karen A. Lillycrop, Graham C. Burdge, Graham C. Burdge, Barbara A. Fielding   +9 more
doaj   +1 more source