Results 1 to 10 of about 6,801 (211)

Genome-wide analysis of oxylipins and oxylipin profiles in a pediatric population [PDF]

Frontiers in Nutrition, 2023
BackgroundOxylipins are inflammatory biomarkers derived from omega-3 and-6 fatty acids implicated in inflammatory diseases but have not been studied in a genome-wide association study (GWAS).
Teresa Buckner, Teresa Buckner, Randi K. Johnson, Randi K. Johnson, Lauren A. Vanderlinden, Patrick M. Carry, Patrick M. Carry, Alex Romero, Suna Onengut-Gumuscu, Wei-Min Chen, Soojeong Kim, Oliver Fiehn, Brigitte I. Frohnert, Tessa Crume, Wei Perng, Katerina Kechris, Marian Rewers, Jill M. Norris   +17 more
doaj   +6 more sources

Synthesis of Oxylipin Mimics and Their Antifungal Activity Against the Citrus Postharvest Pathogens

Molecules, 2016
Nine oxylipin mimics were designed and synthesized starting from d-mannose. Their antifungal activity against three citrus postharvest pathogens was evaluated by spore germination assay.
Zi-Long Li, Jimei Ma
exaly   +4 more sources

Integrated analysis of whole blood oxylipin and cytokine responses after bacterial, viral, and T cell stimulation reveals new immune networks

iScience, 2023
Summary: Oxylipins are major immunomodulating mediators, yet studies of inflammation focus mainly on cytokines. Here, using a standardized whole-blood stimulation system, we characterized the oxylipin-driven inflammatory responses to various stimuli and ...
Etienne Villain, Aurélie Chanson, Malwina Mainka, Nadja Kampschulte, Pauline Le Faouder, Justine Bertrand-Michel, Marion Brandolini-Bulon, Bruno Charbit, Munyaradzi Musvosvi, Nicole Bilek, Thomas J. Scriba, Lluis Quintana-Murci, Nils Helge Schebb, Darragh Duffy, Cécile Gladine, Laurent Abel, Andres Alcover, Hugues Aschard, Philippe Bousso, Nollaig Bourke, Petter Brodin, Pierre Bruhns, Nadine Cerf-Bensussan, Ana Cumano, Christophe D’Enfert, Ludovic Deriano, Marie-Agnès Dillies, James Di Santo, Gérard Eberl, Jost Enninga, Jacques Fellay, Ivo Gomperts-Boneca, Milena Hasan, Gunilla Karlsson Hedestam, Serge Hercberg, Molly A. Ingersoll, Olivier Lantz, Rose Anne Kenny, Mickaël Ménager, Hugo Mouquet, Cliona O'Farrelly, Etienne Patin, Sandra Pellegrini, Antonio Rausell, Frédéric Rieux-Laucat, Lars Rogge, Magnus Fontes, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Frédéric Tangy, Antoine Toubert, Mathilde Touvier, Marie-Noëlle Ungeheuer, Christophe Zimmer, Matthew L. Albert, Darragh Duffy, Lluis Quintana-Murci   +58 more
doaj   +2 more sources

The Emerging Parkinson's Disease Oxylipin‐Ome [PDF]

Advanced Science
Parkinson Disease (PD) is increasingly considered a proteinopathy and lipidopathy. This proteinopathy+lipidopathy paradigm has been further refined to a fatty acid (FA)‐opathy, centering dysregulated FA metabolism as fundamental in PD lipid dysfunction ...
Julia C. Kelliher, Saranna Fanning
doaj   +2 more sources

Oxylipin composition of high-density lipoprotein is altered in men and Hispanic adults with mild cognitive impairment [PDF]

Journal of Lipid Research
High-density lipoprotein (HDL) oxylipins are potent inflammatory mediators. HDL dyshomeostasis and inflammation increase mild cognitive impairment (MCI) and dementia risk, which vary by gender and race/ethnicity.
Julia C. Kelliher, Christopher G. Engeland, Jennifer E. Graham-Engeland, Mindy Katz, Claudette Kessler, Gregory C. Shearer   +5 more
doaj   +2 more sources

Oxylipin Profiling of Alzheimer’s Disease in Nondiabetic and Type 2 Diabetic Elderly

Metabolites, 2019
Oxygenated lipids, called “oxylipins,” serve a variety of important signaling roles within the cell. Oxylipins have been linked to inflammation and vascular function, and blood patterns have been shown to differ in type 2 diabetes (T2D ...
Jill K Morris, John Thyfault, Brian D Piccolo   +2 more
exaly   +3 more sources

Iron chelation targets lipid metabolism to reduce white matter injury in germinal matrix hemorrhage [PDF]

Cell Death and Disease
Germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) leads to neural cell death and inflammation, resulting in white matter injury in premature infants.
Bokun Cheng, Akanksha Mishra, Xusheng Zhang, Zaw Myo Hein, Nourelhoda Gouda, Karen Schaeffer, Mikhail Kislin, Yunping Qiu, Fereshteh Zandkarimi, Irwin J. Kurland, Praveen Ballabh   +10 more
doaj   +2 more sources

Serum Oxylipin Profiles Identify Potential Biomarkers in Patients With Acute Aortic Dissection

Metabolites, 2022
Aortic dissection (AD) is a life-threatening cardiovascular disease with a dismal prognosis. Inflammation plays an important role in AD. Oxylipins are bioactive lipids involved in the modulation of inflammation and may be involved in the pathogenesis and
Yi Jiang, Xinlong Tang, Fudong Fan
exaly   +3 more sources

Comprehensive Analysis of Different Subtypes of Oxylipins to Determine a LC–MS/MS Approach in Clinical Research [PDF]

Metabolites
Background/Objectives: Different oxylipin subtypes have unique biological properties, requiring effective analytical protocols. However, establishing a complete pathway detection protocol for comprehensive oxylipin analysis is challenging.
Yurou Zhao, Zhengyu Fang, Zeyu Li, Yizhe Liu, Yang Bai, Xiaoqing Wang, Hongjun Yang, Na Guo   +7 more
doaj   +2 more sources

Oxylipin secretion by human CD3+ T lymphocytes in vitro is modified by the exogenous essential fatty acid ratio and life stage

Frontiers in Immunology, 2023
Immune function changes across the life stages; for example, senior adults exhibit a tendency towards a weaker cell-mediated immune response and a stronger inflammatory response than younger adults.
Johanna von Gerichten, Annette L. West, Nicola A. Irvine, Elizabeth A. Miles, Philip C. Calder, Philip C. Calder, Karen A. Lillycrop, Graham C. Burdge, Graham C. Burdge, Barbara A. Fielding   +9 more
doaj   +1 more source