Results 41 to 50 of about 6,801 (211)

The Partitioning of Newly Assimilated Linoleic and α-Linolenic Acids Between Synthesis of Longer-Chain Polyunsaturated Fatty Acids and Hydroxyoctadecaenoic Acids Is a Putative Branch Point in T-Cell Essential Fatty Acid Metabolism

Frontiers in Immunology, 2021
Longer-chain polyunsaturated fatty acids (LCPUFAs) ≥20 carbons long are required for leukocyte function. These can be obtained from the diet, but there is some evidence that leukocytes can convert essential fatty acids (EFAs) into LCPUFAs. We used stable
Johanna von Gerichten, Annette L. West, Nicola A. Irvine, Elizabeth A. Miles, Philip C. Calder, Philip C. Calder, Karen A. Lillycrop, Barbara A. Fielding, Graham C. Burdge   +8 more
doaj   +1 more source

Oxylipin levels, by intervention arm: Median (interquartile range).

, 2018
Oxylipin levels, by intervention arm: Median (interquartile range).
Bruce D. Hammock (65754), Jessica A. Martinez (2297254), Denise J. Roe (429202), Jun Yang (2084), David S. Alberts (3024495), Patricia A. Thompson (209907), Betsy C. Wertheim (5146601), Peter Lance (198534), Alexander Schriewer (4184308)   +8 more
core   +1 more source

Data_Sheet_1_Genome-wide analysis of oxylipins and oxylipin profiles in a pediatric population.docx

, 2023
BackgroundOxylipins are inflammatory biomarkers derived from omega-3 and-6 fatty acids implicated in inflammatory diseases but have not been studied in a genome-wide association study (GWAS).
Katerina Kechris (436022), Marian Rewers (135498), Wei-Min Chen (110472), Alex Romero (3026163), Wei Perng (408576), Soojeong Kim (2570422), Brigitte I. Frohnert (3907327), Tessa Crume (14847844), Randi K. Johnson (10645819), Suna Onengut-Gumuscu (282049), Oliver Fiehn (17098), Jill M. Norris (8789516), Lauren A. Vanderlinden (436020), Patrick M. Carry (6338369), Teresa Buckner (10645820)   +14 more
core   +1 more source

Oxylipin Signaling and Plant Growth

, 2009
Oxylipins are derived from the oxidation of polyunsaturated fatty acids. Further conversion of the resulting fatty acid hydroperoxides gives rise to a multitude of oxylipin classes, including hydroxy-, oxo-, or keto fatty acids, volatile aldehydes, and ...
Heilmann, Ingo, Munnik, Teun, Mosblech, Alina, Feussner, Ivo, Ingo Heilmann, Ivo Feussner, Alina Mosblech   +6 more
core   +1 more source

Epoxy-Oxylipins and Soluble Epoxide Hydrolase Metabolic Pathway as Targets for NSAID-Induced Gastroenteropathy and Inflammation-Associated Carcinogenesis

Frontiers in Pharmacology, 2019
Polyunsaturated fatty acids (PUFAs) including epoxide-modified ω-3 and ω-6 fatty acids are made via oxidation to create highly polarized carbon-oxygen bonds crucial to their function as signaling molecules.
Ryan D. Jones, Jie Liao, Xin Tong, Dandan Xu, Leyu Sun, Haonan Li, Guang-Yu Yang   +6 more
doaj   +1 more source

Multifunctional Enzymes in Oxylipin Metabolism

ChemBioChem, 2008
Fingers in lots of pies: For the first time a member of the CYP74 enzyme subfamily (9‐AOS) from tomato has been shown by chemical and analytical approaches to catalyze multiple reactions. These multifunctional properties of 9‐AOS from the oxylipin‐forming lipoxygenase (LOX) pathway raise several new questions on lipid‐derived signaling.
Wasternack, Claus, Feussner, Ivo
openaire   +3 more sources

Conditionally Significant eQTL and TWAS Analyses Identify MsRD26 as a Major Candidate Positive Regulator of Salt Tolerance in Medicago sativa L

Advanced Science, EarlyView.
Salt stress significantly impacts plant growth. Through population transcriptome, eQTL and TWAS analyses, we identified several candidate genes potentially associated with salt stress response. Functional assays suggested that some of these genes may contribute to salt tolerance.
Lin Chen, Yuqi Zhang, Xinyue Ma, Jinpeng Bi, Fei He, Li Zhao, Haiyue Lei, Zhengqin Xiao, Xue Wang, Tiejun Zhang, Ruicai Long, Junmei Kang, Qingchuan Yang   +12 more
wiley   +1 more source

Loss of the mammalian G-protein coupled receptor, G2A, modulates severity of invasive pulmonary aspergillosis

Frontiers in Immunology, 2023
BackgroundAspergillus fumigatus is a well-known opportunistic pathogen that causes a range of diseases including the often-fatal disease, invasive pulmonary aspergillosis (IPA), in immunocompromised populations.
Breanne N. Steffan, Dante Calise, Sung Chul Park, Mengyao Niu, Jun Yang, Bruce D. Hammock, MaryJane Jones, Chad Steele, Nancy P. Keller, Nancy P. Keller   +9 more
doaj   +1 more source

USP4‐Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC

Advanced Science, EarlyView.
USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian, Yun Tong, Wenkai Ni, Zhangzhi Tang, Weiting Chen, Kexin Ma, Lihan Jiang, Jiayu Shao, Xuyang He, Wenjie Zheng   +9 more
wiley   +1 more source

Role of oxylipins in cardiovascular diseases [PDF]

Acta Pharmacologica Sinica, 2018
Globally, cardiovascular diseases (CVDs) are the number one cause of mortality. Approximately 18 million people died from CVDs in 2015, representing more than 30% of all global deaths. New diagnostic tools and therapies are eagerly required to decrease the prevalence of CVDs related to mortality and/or risk factors leading to CVDs.
openaire   +2 more sources