Results 61 to 70 of about 6,801 (211)

EPHX2 Loss Promotes CRC Migration via EET‐Dependent Chemokine Elevation and Mitochondrial Defect

Cancer Science, EarlyView.
Loss of EPHX2 promotes EET accumulation, which in turn enhances CXCL and ROS production, thereby promoting the migratory and invasive abilities of CRC cells. ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and ...
Jianjun Zhu, Jingjia Chang, Zhiyong Li, Jin Wu, Pengfei Yu, Jingjing Zheng, Li Li, Jia Tao, Hao Wu, Yintao Li, Ming Liu   +10 more
wiley   +1 more source

Circadian disruption elicits sex‐specific gut microbiota, endocannabinoidome, and lipid mediator responses

The FEBS Journal, EarlyView.
Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki, Timothy D. Niepokny, Tina Khalilzadehsabet, Elizabeth Dumais, Nicolas Flamand, Vincenzo Di Marzo, Eric M. Mintz, Cristoforo Silvestri   +7 more
wiley   +1 more source

Linoleic Acid Enhances Murine Natural Killer Cell Function In Vitro but Compromises Mitochondrial Bioenergetic Function During Retroviral Infection

Immunology, EarlyView.
Natural Killer (NK) cells are potent effectors against virus‐infected and tumour cells. During Friend Virus (FV) infection, fatty acid metabolism supports NK‐cell effector functions. Here, we found that NK cells from FV‐infected mice preferentially take up linoleic acid (LA), which reduced proliferation, mitochondrial function, and increased reactive ...
Vaasudevan Sridhar, Simone Schimmer, Tanja Werner, Rachel Giesen, Mohamed Saad, Constantin P. Krempe, Sven W. Meckelmann, Ulf Dittmer, Elisabeth Littwitz‐Salomon   +8 more
wiley   +1 more source

Inactivation of Carbonyl-Detoxifying Enzymes by H₂O₂ Is a Trigger to Increase Carbonyl Load for Initiating Programmed Cell Death in Plants

Antioxidants, 2020
H2O2-induced programmed cell death (PCD) of tobacco Bright Yellow-2 (BY-2) cells is mediated by reactive carbonyl species (RCS), degradation products of lipid peroxides, which activate caspase-3-like protease (C3LP).
Md. Sanaullah Biswas, Ryota Terada, Jun’ichi Mano   +2 more
doaj   +1 more source

Volatile organic compounds orchestrating microbiome‐mediated crop resilience: Prospects and challenges for sustainable agriculture

Journal of Integrative Plant Biology, EarlyView.
Herbivory triggers the production of green leaf volatiles, and dense planting results in induces increased concentration of linalool emission in maize canopies. These volatiles activate plant‐soil feedback that enriches beneficial rhizosphere bacteria, enhancing resistance, though sometimes at a growth cost, thereby offering new avenues for sustainable
Peiguo Yuan, Esau De la Vega‐Camarillo, Michael V. Kolomiets, Sanjay Antony‐Babu   +3 more
wiley   +1 more source

Oxylipin transport by lipoprotein particles and its functional implications for cardiometabolic and neurological disorders [PDF]

Lipoprotein metabolism is critical to inflammation. While the periphery and central nervous system (CNS) have separate yet connected lipoprotein systems, impaired lipoprotein metabolism is implicated in both cardiometabolic and neurological disorders ...
Liang, Nuanyi, Newman, John W, Zhou, Sitong, Kaddurah-Daouk, Rima, Borkowski, Kamil, Harsch, Brian A, Shearer, Gregory C, Borkowska, Alison   +7 more
core   +1 more source

Jasmonate biosynthesis regulates key events in barley vegetative and reproductive development

New Phytologist, EarlyView.
Generation and general phenotypes of hvaoc mutants. Summary Cereal grain is a global food staple. Filial tissues in grain, such as the embryo and endosperm, grow embedded in the maternal ovule and surrounding ovary wall. Maternal tissues provide nutrition and protection but are progressively reduced and degraded as filial tissues expand, driving grain ...
Jian Luo, Linsan Liu, Xiujuan Yang, Olivia Doolan, Tanicha Duangta, Emily Lyon, Jonathan Griffin, Jennifer Shoesmith, Wenhao Wu, Ruth Hamilton, Mirjam Nuter, Mikah Katay‐Fodor, Neil Bricklebank, Nicola Aberdein, Guoping Zhang, Colin Turnbull, Matthew R. Tucker, Sarah M. McKim   +17 more
wiley   +1 more source

A New Generation of Postbiotics for Skin and Scalp: In Situ Production of Lipid Metabolites by Malassezia

Microorganisms
Effects of pre- and probiotics on intestinal health are well researched and microbiome-targeting solutions are commercially available. Even though a trend to appreciate the presence of certain microbes on the skin is seeing an increase in momentum, our ...
Martin Patrick Pagac, Mathias Gempeler, Remo Campiche   +2 more
doaj   +1 more source

Apoplast multi‐omics profiling during fungal infection uncovers new players of basal and early induced immunity in Arabidopsis thaliana

New Phytologist, EarlyView.
Important processes taking place in the apoplast during plant–pathogen interaction identified by multi‐omics profiling of the apoplastic fluid. Summary The extracellular space in plant tissues, known as the apoplast, remains one of the least characterized cellular compartments.
Antoine Davière, Sylvie Jolivet, Annie Auger, Gilles Clement, Stephanie Boutet, Jean Chrisologue Totozafy, Thierry Balliau, Mélisande Blein‐Nicolas, Justine Rouffet, Marie‐Christine Soulié, Mathilde Fagard   +10 more
wiley   +1 more source

Changes in serum oxylipin profile after one anastomosis gastric bypass

, 2023
Raw LC-MS/MS files for the article titled Changes in serum oxylipin profile after one anastomosis gastric bypass by Pakiet et al.Deposited are calibration curve analysis and data from analysis of serum in patients that undergo treatment for obesity with ...
Pakiet, Alicja
core   +1 more source