Results 31 to 40 of about 57,321 (288)
The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei [PDF]
, 2010 Sphingomyelin is the main sphingolipid in Trypanosoma brucei, the causative agent of African sleeping sickness. In vitro and in vivo characterization of the T.
Smith, Terry K. +2 more
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Targeting Ceramides and Adiponectin Receptors in the Islet of Langerhans for Treating Diabetes
Molecules, 2022 Ceramides belong to the sphingolipid family and represent the central hub of the sphingolipid network. In obesity, oversupply of saturated fatty acids including palmitate raises ceramide levels which can be detrimental to cells.
Wen-hong Li
doaj +1 more source
Mechanisms of sphingolipid functions during heat stress in "Saccharomyces cerevisiae" [PDF]
, 2005 Sphingolipids are important membrane constituents in all eukaryotic cells. Ongoing sphingolipid synthesis is required for a variety of cellular processes including response to heat shock.
Meier, Karsten D.
core +1 more source
Frontiers in Oncology, 2021 Prostate cancer is the second most prevalent malignancy worldwide. In the early stages, the development of prostate cancer is dependent on androgens. Over time with androgen deprivation therapy, 20% of prostate cancers progress to a castration-resistant ...
I Gusti Md Gde Surya C. Trapika +18 more
doaj +1 more source
Metabolism of HSAN1- and T2DM-associated 1-deoxy-sphingolipids inhibits the migration of fibroblasts
Journal of Lipid Research, 2021 Hereditary sensory neuropathy type 1 (HSAN1) is a rare axonopathy, characterized by a progressive loss of sensation (pain, temperature, and vibration), neuropathic pain, and wound healing defects.
Gergely Karsai +5 more
doaj +1 more source
European Respiratory Review, 2019 Sphingolipids are a distinct class of lipid molecules widely found in nature, principally as cell membrane constituents. After initial uncertainty about their function, sphingolipids have been increasingly recognised to be metabolically active entities involved in many biological processes, including the control of inflammation. Their role as mediators
Raja Chandra Chakinala +4 more
openaire +3 more sources
Toxins2-Amino-14,16-dimethyloctadecan-3-ol (AOD) is commonly found in foods contaminated with Fusarium avenaceum, particularly cereals or fruits, and is structurally related to Fusarium mycotoxins (fumonisins) and mammalian sphingoid bases, especially 1 ...
Shenlong Mo +7 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2021 Aortic dissection (AD) is a catastrophic cardiovascular emergency with a poor prognosis, and little preceding symptoms. Abnormal lipid metabolism is closely related to the pathogenesis of AD.
Huang Huang +14 more
doaj +1 more source
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
Circulating sphingolipids in heart failure
Frontiers in Cardiovascular Medicine, 2023 Lack of significant advancements in early detection and treatment of heart failure have precipitated the need for discovery of novel biomarkers and therapeutic targets.
Anna Kovilakath +3 more
doaj +1 more source