Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis. [PDF]
Biomedicines, 2023 Horse-derived ceramide (HC), which contains galactosylceramides as its main component, significantly improves skin symptoms when applied topically to patients with atopic dermatitis. We speculated that efficacy resulted from the amelioration of epidermal
Igarashi T +4 more
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Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury. [PDF]
Neural Regen ResMicroglia, the resident monocyte of the central nervous system, play a crucial role in the response to spinal cord injury. However, the precise mechanism remains unclear.
Zhang W +8 more
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Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death. [PDF]
Mol Ther, 2022 Emerging clinical data show that three ceramide molecules, Cer d18:1/16:0, Cer d18:1/24:1, and Cer d18:1/24:0, are biomarkers of a fatal outcome in patients with cardiovascular disease.
Schmidt S +11 more
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Overexpression of a ceramide synthase gene,GhCS1, inhibits fiber cell initiation and elongation by promoting the synthesis of ceramides containing dihydroxy LCB and VLCFA. [PDF]
Front Plant Sci, 2022 Cotton is an important natural fiber crop worldwide. Cotton fiber cell is regarded as an ideal material for studying the growth and development of plant cells.
Li G +8 more
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Downregulation of ceramide synthase 1 promotes oral cancer through endoplasmic reticulum stress. [PDF]
Int J Oral Sci, 2021 C18 ceramide plays an important role in the occurrence and development of oral squamous cell carcinoma. However, the function of ceramide synthase 1, a key enzyme in C18 ceramide synthesis, in oral squamous cell carcinoma is still unclear. The aim of our
Chen W +11 more
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Ceramide synthase 4 interferes with replication of influenza virus but is downregulated by infection. [PDF]
J VirolInfluenza continues to pose a serious threat to humans. Influenza-host interaction is incompletely understood, requiring identification of host factors that regulate viral pathogenicity.
Jung KI +6 more
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Glycosylation of ceramide synthase 6 is required for its activity. [PDF]
J Lipid ResSphingolipids play key roles in membrane structure and cellular signaling. Ceramide synthase (CerS)-generated ceramide is implicated in cellular stress responses and induction of apoptosis.
Straus AJ, Mavodza G, Senkal CE.
europepmc +2 more sources
Protocol for screening inhibitors of the fungal sphingolipid-metabolizing enzyme ceramide synthase. [PDF]
STAR ProtocSummary: Fungal sphingolipids have emerged as potent antifungal targets based on cumulative evidence demonstrating that fungal sphingolipid metabolism is essential to the virulence of pathogenic fungi. Here, we present a protocol to screen for inhibitors
Zhong A +4 more
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Cannabidiol's cytotoxicity in pancreatic cancer is induced via an upregulation of ceramide synthase 1 and ER stress. [PDF]
J Cannabis ResPancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies with a median 5 year-survival rate of 12%. Cannabidiol (CBD) has been found to exhibit antineoplastic potential and may potentiate the anticancer effects of cytotoxic’
Mangal N +3 more
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Structure and mechanism of a eukaryotic ceramide synthase complex. [PDF]
EMBO J, 2023 Xie T +5 more
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