Structure and mechanism of a eukaryotic ceramide synthase complex [PDF]
EMBO Journal, 2023 Ceramide synthases (CerS) catalyze ceramide formation via N‐acylation of a sphingoid base with a fatty acyl‐CoA and are attractive drug targets for treating numerous metabolic diseases and cancers.
Tian Xie, Qi Fang, Zike Zhang
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Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis [PDF]
Biomedicines, 2023 Horse-derived ceramide (HC), which contains galactosylceramides as its main component, significantly improves skin symptoms when applied topically to patients with atopic dermatitis. We speculated that efficacy resulted from the amelioration of epidermal
, Genji Imokawa, Imokawa Genji
exaly +6 more sources
Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury [PDF]
Neural Regeneration ResearchMicroglia, the resident monocyte of the central nervous system, play a crucial role in the response to spinal cord injury. However, the precise mechanism remains unclear.
Wei Zhang +8 more
doaj +3 more sources
Downregulation of ceramide synthase 1 promotes oral cancer through endoplasmic reticulum stress [PDF]
International Journal of Oral Science, 2021 C18 ceramide plays an important role in the occurrence and development of oral squamous cell carcinoma. However, the function of ceramide synthase 1, a key enzyme in C18 ceramide synthesis, in oral squamous cell carcinoma is still unclear. The aim of our
Wen Chen +11 more
doaj +3 more sources
Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death [PDF]
Molecular Therapy, 2022 Emerging clinical data show that three ceramide molecules, Cer d18:1/16:0, Cer d18:1/24:1, and Cer d18:1/24:0, are biomarkers of a fatal outcome in patients with cardiovascular disease.
Sandra F Gallego +2 more
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Self-Protection against the Sphingolipid Biosynthesis Inhibitor Fumonisin B1 Is Conferred by a
mBio, 2020 Fumonisin (FB) mycotoxins produced by species of the genus Fusarium detrimentally affect human and animal health upon consumption, due to the inhibition of ceramide synthase.
Slavica Janevska +7 more
doaj +3 more sources
Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance It is well known that because of constant metabolic flow and interconnectivity, alteration of any one step in lipid metabolism can lead to changes in many lipid metabolites.
Stefka D Spassieva +2 more
exaly +5 more sources
Ceramide Synthase 6: Comparative Analysis, Phylogeny and Evolution [PDF]
Biomolecules, 2018 Ceramide synthase 6 (CerS6, also known as LASS6) is one of the six members of ceramide synthase gene family in humans. Comparisons of CerS6 amino acid sequences and structures as well as of CerS6 gene structures/locations were conducted using data from ...
Roger S. Holmes +2 more
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Structural basis of the mechanism and inhibition of a human ceramide synthase. [PDF]
Nat Struct Mol Biol, 2023 Ceramides are bioactive sphingolipids that play pivotal roles in regulating cellular metabolism. Ceramides and dihydroceramides are synthesized by a family of six ceramide synthase enzymes (CerS), each with distinct specificity for the acyl-CoA substrate.
Pascoa TC +12 more
europepmc +2 more sources
Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy
European Journal of Cell Biology, 2023 Different studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer.
Javad Alizadeh +11 more
doaj +4 more sources