Results 31 to 40 of about 194,964 (167)
Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response
Cell Reports, 2021 Summary: We lack a mechanistic understanding of aging-mediated changes in mitochondrial bioenergetics and lipid metabolism that affect T cell function.Silvia Vaena, Paramita Chakraborty, Han Gyul Lee, Alhaji H. Janneh, Mohamed Faisal Kassir, Gyda Beeson, Zachariah Hedley, Ahmet Yalcinkaya, M. Hanief Sofi, Hong Li, Monica L. Husby, Robert V. Stahelin, Xue-Zhong Yu, Shikhar Mehrotra, Besim Ogretmen +14 moredoaj +1 more sourceGenetic Determinants of Circulating Sphingolipid Concentrations in European Populations [PDF]
, 2009 Sphingolipids have essential roles as structural components of cell membranes and in cell signalling, and disruption of their metabolism causes several diseases, with diverse neurological, psychiatric, and metabolic consequences.S. Campbell, Aulchenko, Y.S. (Yurii), Igl, Wilmar,, Zaboli, Ghazal, Polasek, O. (Ozren), A. Wright, J. F. Wilson, Gyllensten, U, Hicks, Andrew A, Schwienbacher, C, Hengstenberg, Christian, I. R. König, Peter Ugocsai, A. Demirkan, C. Pattaro, Wichmann, H.-E., G. Liebisch, Peters, Annette, Kirichenko, Anatoly V, Liebisch, G, Peters, A. (Annette), Witteman, Jacqueline C. M., Wright, Alan, C. Hengstenberg, O. Polasek, König, Inke R, P. Ugocsai, Janssens, A. Cecilej W., Hayward, C., Campbell, Harry, Campbell, H, Pichler, I. (Irene), Pichler, I., Gerhard Liebisch, Demirkan, A., Campbell, S, Biloglav, Z. (Zrinka), P. P. Pramstaller, Kolcic, I, Johansson, Asa, Liebisch, Gerhard, C. M. van, Wichmann, H.E. (Heinz Erich), Janssens, A Cecilej W, Meitinger, T., Wild, SH, Ozren Polasek, Igl, W., Jeanette Erdmann, Schmitz, G, Franklin, CS, S. Schreiber, Jonasson, I, Wichmann, H-Erich, Ugocsai, P, Polsek, Ozren, Wichmann, H.-Erich, Cornelia M van Duijn, Hengstenberg, C, Erdmann, J. (Jeanette), H. Campbell, König, I.R. (Inke), Axenovich,T.I., G. Schmitz, Y. Aulchenko, S. H. Wild, Schreiber, Stefan, Gyllensten, Ulf,, Campbell, Harry; id_orcid, I. Rudan, G. Zaboli, Schreiber, S., Ivana Kolcic, Johansson, A, Wright, A, Franklin, Christopher S, Kolcic, I., Zorkoltseva, I.V. (Irina), Wilson, J.F., Rudan, I. (Igor), Johansson, A. (Åsa), Zorkoltseva, I.V., Schwienbacher, Christine, Duijn, Cornelia, Marroni, Fabio, Witteman, Jacqueline C M, Fabio Marroni, Zaboli, Ghazal,, Jonasson, Inger, Hicks, A.A. (Andrew), Irene Pichler, Gyllensten, U., Campbell, H., Wichmann, HE, A Cecilej W Janssens, Pramstaller, P.P. (Peter Paul), Janssens, A.C., Peters, A., Wild, S.H., Isaacs, A., Pichler, Irene, Vitart, Veronique, N. Hastie, Tatiana I Axenovich, Johansson, Åsa,, I. Kolcic, Ghazal Zaboli, James F Wilson, Kolcic, I. (Ivana), Wilson, James F; id_orcid, Biloglav, Zrinka, Ugocsai, P. (Peter), Gnewuch, C., A. Johansson, Zaboli, G., Marroni, F, Andrew A Hicks, Pattaro, C., Pichler, I, Christian Hengstenberg, Jacqueline C M Witteman, Schunkert, H, Biloglav, Z, Caroline Hayward, Pattaro, Cristian, C. Hayward, Koenig, Inke R., Zrinka Biloglav, Demirkan, A. (Ayşe), Liebisch, G., J. Erdmann, Franklin, C.S. (Christopher), I. V. Zorkoltseva, U. Gyllensten, Alan Wright, Pattaro, C, Franklin, Christopher S., Hengstenberg, C. (Christian), A. V. Kirichenko, Harry Campbell, Schunkert, H., W. Igl, Hastie, N., Ulf Gyllensten, C. Schwienbacher, Kirichenko, AV, Demirkan, Ayse, Janssens, A. CecileJ.W., Schreiber, S, Wild, S.H. (Sarah), Zorkoltseva, IV, Schwienbacher, C. (Christine), Erdmann, Jeanette, Yurii Aulchenko, Asa Johansson, Ben A Oostra, Aulchenko, Y., Veronique Vitart, Liebisch, G. (Gerhard), B. A. Oostra, Janssens, Cecile, Christine Schwienbacher, Hastie, N, A. C. W, Rudan, Igor, Igl, W. (Wilmar), I. Pichler, Erdmann, J., C. Gnewuch, Konig, IR, Anatoly V Kirichenko, Schwienbacher, C., van Duijn, C.M., Jonasson, I., Kirichenko, A.V. (Anatoly), Schmitz, G., Hicks, Andrew A., A. A. Hicks, Susan Campbell, Annette Peters, Gerd Schmitz, Hayward, Caroline, Zorkoltseva, Irina V, Witteman, JCM, T. I. Axenovich, Gnewuch, C, König, I.R., Carsten Gnewuch, H. Wichmann, Gyllensten, Ulf, Igl, Wilmar, Meitinger, T, Kirichenko, Anatoly V., H-Erich Wichmann, Cristian Pattaro, C. S. Franklin, Gnewuch, Carsten, König, Inke R., Isaacs, A.J. (Aaron), Erdmann, J, Zaboli, G. (Ghazal), Christopher S Franklin, Campbell, S., Irina V Zorkoltseva, Zorkoltseva, Irina V., Hengstenberg, C., Zaboli, G, Hicks, A.A., Peter P Pramstaller, Marroni, F. (Fabio), Sarah H Wild, Ayse Demirkan, Johansson, A., Wright, A., Hicks, AA, Wichmann, Heinz-Erich, Nick Hastie, Hastie, Nick, H. Schunkert, Polasek, Ozren, Janssens, A. Cecile J. W., Inger Jonasson, Axenovich, TI, Polasek, O., Peters, A, Oostra, Ben A., Oostra, B.A., Wright, A.F. (Alan), Axenovich, T.I. (Tatiana), van Duijn, Cornelia M., Heribert Schunkert, Vitart, V. (Veronique), Hastie, N. (Nick), Wild, Sarah H; id_orcid, Schmitz, Gerd, Hayward, C. (Caroline), Biloglav, Z., Schunkert, H. (Heribert), Campbell, S. (Susan), A. Peters, Ugocsai, Peter, T. Meitinger, Oostra, Ben, Inke R König, Kolcic, Ivana, Stefan Schreiber, Gibson, Greg, Schunkert, Heribert, Z. Biloglav, Rudan, I., Isaacs, Aaron, V. Vitart, Tikka-Kleemola, P. (Päivi), Wilson, JF, Oostra, B.A. (Ben), Franklin, C.S., Jonasson, I. (Inger), Wilson, James F., Schreiber, S. (Stefan), Pramstaller, Peter P, Rudan, I, Wild, Sarah H., Schmitz, G. (Gerd), Janssens, A.C.J.W. (Cécile), Oostra, Ben A, Vitart, V, Meitinger, Thomas, Vitart, V., Aulchenko, Yurii, Pramstaller, PP, Gnewuch, C. (Carsten), Marroni, F., Campbell, Susan, Axenovich, Tatiana I., Hayward, C, Witteman, J.C.M. (Jacqueline), J. C. M, Wilmar Igl, Igl, W, Axenovich, Tatiana I, Kirichenko, A.V., Aulchenko, Yuriy, Wilson, J.F. (James), Gyllensten, U. (Ulf), van Duijn, Cornelia M, Meitinger, T. (Thomas), Hayward, Caroline; id_orcid, Thomas Meitinger, Ugocsai, P., Pattaro, C. (Cristian), Polasek, O, I. Jonasson, Pramstaller, Peter P., Aaron Isaacs, Igor Rudan, Witteman, J.C., Jonasson, Inger,, A. Isaacs, Pramstaller, P.P., Wild S. H., Schmitz G., Hastie Nick, Schreiber S., Campbell Susan, Peters Annette, Erdmann Jeanette, Wright A., Oostra B. A., Vitart Veronique, Zorkoltseva I. V, Witteman J. C., Johansson A, Zaboli Ghazal, Schreiber Stefan, Ugocsai P, König I. R., Pichler I., Liebisch Gerhard, Aulchenko Y, Hastie N., Pattaro C, Wild Sarah H., Zaboli G., Aulchenko Yurii, Isaacs A., Wichmann H. E., Hicks, AA;Pramstaller, PP;Johansson, Å;Vitart, V;Rudan, I;Ugocsai, P;Aulchenko, Y;Franklin, CS;Liebisch, G;Erdmann, J;Jonasson, I;Zorkoltseva, IV;Pattaro, C;Hayward, C;Isaacs, A;Hengstenberg, C;Campbell, S;Gnewuch, C;Janssens, AC;Kirichenko, AV;König, IR;Marroni, F;Polasek, O;Demirkan, A;Kolcic, I;Schwienbacher, C;Igl, W;Biloglav, Z;Witteman, JC;Pichler, I;Zaboli, G;Axenovich, TI;Peters, A;Schreiber, S;Wichmann, HE;Schunkert, H;Hastie, N;Oostra, BA;Wild, SH;Meitinger, T;Gyllensten, U;van Duijn, CM;Wilson, JF;Wright, A;Schmitz, G;Campbell, H, Schmitz Gerd, Kolcic Ivana, Campbell S., Schunkert H., Gyllensten U., Franklin Christopher S., Demirkan A., Liebisch G, Axenovich T. I., Rudan Igor, Witteman Jacqueline C. M., Wichmann H.-Erich, Hengstenberg Christian, Pramstaller PP, van Duijn Cornelia M., Oostra Ben A., Rudan I, Vitart V, Kolcic I., Ugocsai Peter, Gnewuch C., Franklin CS, Gyllensten Ulf, Biloglav Zrinka, Wilson James F., Igl Wilmar, Marroni F., Schunkert Heribert, van Duijn C. M., Zorkoltseva Irina V., Meitinger T., Meitinger Thomas, Kirichenko Anatoly V., Pichler Irene, Janssens A. C., Campbell H., Jonasson Inger, Biloglav Z., Peters A., Johansson Åsa, Hicks Andrew A., Demirkan Ayse, Isaacs Aaron, Hayward C., Hayward Caroline, Jonasson I, Kirichenko A. V., Erdmann J, Igl W., Schwienbacher Christine, Axenovich Tatiana I., Marroni Fabio, Polasek O., Pramstaller Peter P., Janssens A. CecileJ.W., Hicks AA, Pattaro Cristian, Polasek Ozren, Wilson J. F., Wright Alan, Gnewuch Carsten, Campbell Harry, Hengstenberg C., König Inke R. +390 morecore +2 more sourcesRoles of Ceramide Synthase and Ceramide Clearence Genes in Nilotinib-Induced Cell Death in Chronic Myeloidleukemia Cells [PDF]
, 2011 In this study, we aimed to increase the sensitivity of human K562 and Meg-01 chronic myeloid leukemia (CML) cells to nilotinib by targeting bioactive sphingolipids, in addition to investigating the roles of ceramide metabolizing genes in nilotinib ...Gençer, Emel Başak, Avcu, Ferit, Baran, Yusuf, Ural, Ali Uğur, Camgöz, Aylin +4 morecore +2 more sourcesAll members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity[S]
Journal of Lipid Research, 2015 Sphingomyelin synthase-related protein (SMSr) synthesizes the sphingomyelin analog ceramide phosphoethanolamine (CPE) in cells. Previous cell studies indicated that SMSr is involved in ceramide homeostasis and is crucial for cell function.Tingbo Ding, Inamul Kabir, Yue Li, Caixia Lou, Amirfarbod Yazdanyar, Jiachen Xu, Jibin Dong, Hongwen Zhou, Taesik Park, Mohamed Boutjdir, Zhiqiang Li, Xian-Cheng Jiang +11 moredoaj +1 more sourceCeramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals [PDF]
, 1995 The sphingomyelin pathway, which is initiated by sphingomyelin hydrolysisto generate the second messenger ceramide, signals apoptosis for tumor necrosis factor α, Fas, and ionizing radiation.Haimovitz-Friedman, Adriana, Adriana Haimovitz-Friedman, Zvi Fuks, Fuks, Zvi, Marcel Verheij, Ron Bose, Bose, Ron, Kathleen Scotto, Verheij, Marcel, Scotto, Kathleen, Richard Kolesnick, Kolesnick, Richard +11 morecore +1 more sourceLactosylceramide contributes to mitochondrial dysfunction in diabetes
Journal of Lipid Research, 2016 Sphingolipids have been implicated as key mediators of cell-stress responses and effectors of mitochondrial function. To investigate potential mechanisms underlying mitochondrial dysfunction, an important contributor to diabetic cardiomyopathy, we ...Sergei A. Novgorodov, Christopher L. Riley, Jin Yu, Jarryd A. Keffler, Christopher J. Clarke, An O. Van Laer, Catalin F. Baicu, Michael R. Zile, Tatyana I. Gudz +8 moredoaj +1 more sourceCeramide-1-Phosphate Is Involved in Therapy-Induced Senescence
, 2022 Sphingolipids
are key signaling lipids and their dysregulation
has been associated with various cellular processes. We have previously
shown significant changes in sphingolipids in therapy-induced senescence,
a state of cell cycle arrest as a response to Jonna Frasor (841097), G. Ekin Atilla-Gokcumen (1646659), Nicole Colon-Rosa, Alec Millner (12323222), Logan Running (12323225), Alec Millner, G. Ekin Atilla-Gokcumen, Logan Running, Diana S. Aga, Nicole Colon-Rosa (12323228), Diana S. Aga (1616572), Jonna Frasor +11 morecore +1 more source
