Results 31 to 40 of about 338,348 (241)
A fluorescent assay for ceramide synthase activity [PDF]
Journal of Lipid Research, 2012 The sphingolipids are a diverse family of lipids with important roles in membrane compartmentalization, intracellular signaling, and cell-cell recognition. The central sphingolipid metabolite is ceramide, formed by the transfer of a variable length fatty
Hyun Joon Kim +4 more
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Cannabidiol’s cytotoxicity in pancreatic cancer is induced via an upregulation of ceramide synthase 1 and ER stress [PDF]
Journal of Cannabis ResearchPancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies with a median 5 year-survival rate of 12%. Cannabidiol (CBD) has been found to exhibit antineoplastic potential and may potentiate the anticancer effects of cytotoxic’
Nagina Mangal +3 more
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Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner. [PDF]
PLoS ONE, 2016 We previously reported that ceramide synthase 6 (CerS6) is elevated in response to folate stress in cancer cells, leading to enhanced production of C16-ceramide and apoptosis. Antifolate methotrexate (MTX), a drug commonly used in chemotherapy of several
Baharan Fekry +3 more
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Transmembrane topology of ceramide synthase in yeast [PDF]
Biochemical Journal, 2006 Ceramide plays a crucial role as a basic building block of sphingolipids, but also as a signalling molecule mediating cell-fate decisions. Three genes, LAG1, LAC1 and LIP1, have been shown to be required for ceramide synthase activity in Saccharomyces cerevisiae [Guillas, Kirchman, Chuard, Pfefferli, Jiang, Jazwinski and Conzelman (2001) EMBO J.
Yahara, Natsuko, Riezman, Howard
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The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans [PDF]
Cell Reports, 2018 Summary: Cryptococcus neoformans (C. neoformans) is estimated to cause about 220,000 new cases every year in patients with AIDS, despite advances in antifungal treatments. C.
Mansa A. Munshi +7 more
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Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells. [PDF]
J Clin Invest, 2019 Suzuki M +29 more
europepmc +3 more sources
Mammalian ceramide synthases [PDF]
IUBMB Life, 2010 AbstractIn mammals, ceramide, a key intermediate in sphingolipid metabolism and an important signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of which synthesizes ceramides with distinct acyl chain lengths. There are a number of common biochemical features between the CerS, such as their catalytic mechanism, and ...
Michal, Levy, Anthony H, Futerman
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Inhibitors of specific ceramide synthases [PDF]
Biochimie, 2012 Ceramide synthases (CerSs) are key enzymes in the biosynthesis of ceramides and display a group of at least six different isoenzymes (CerS1-6). Ceramides itself are bioactive molecules. Ceramides with different N-acyl side chains (C(14:0)-Cer - C(26:0)-Cer) possess distinct roles in cell signaling.
Susanne, Schiffmann +9 more
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Ceramide Production Mediates Aldosterone-Induced Human Umbilical Vein Endothelial Cell (HUVEC) Damages. [PDF]
PLoS ONE, 2016 Here, we studied the underlying mechanism of aldosterone (Aldo)-induced vascular endothelial cell damages by focusing on ceramide. We confirmed that Aldo (at nmol/L) inhibited human umbilical vein endothelial cells (HUVEC) survival, and induced ...
Yumei Zhang +7 more
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