Results 31 to 40 of about 34,100 (243)

Ceramide Synthase 2 Promotes Cardiac Very-Long-Chain Dihydroceramide Accumulation and Is Linked to Arrhythmias and Heart Failure in Humans. [PDF]

Int J Mol Sci
Andersson L, Cinato M, Björnson E, Lundqvist A, Miljanovic A, Henricsson M, Bergh PO, Adiels M, Jeppsson A, Borén J, Levin MC.   +10 more
europepmc   +3 more sources

Ursodeoxycholic acid alleviates aortic aneurysm and dissection through the intestinal farnesoid X receptor/ceramide synthase 2 axis. [PDF]

Commun Biol
Zhang Z, Xie L, Lin X, He J, Xie Y, Li J, Zhuang X, Tang L, Xie R, Wu Q, Qiu Z, Chen L.   +11 more
europepmc   +3 more sources

Mammalian ceramide synthases [PDF]

IUBMB Life, 2010
AbstractIn mammals, ceramide, a key intermediate in sphingolipid metabolism and an important signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of which synthesizes ceramides with distinct acyl chain lengths. There are a number of common biochemical features between the CerS, such as their catalytic mechanism, and ...
Michal, Levy, Anthony H, Futerman
openaire   +3 more sources

A tissue-specific screen of ceramide expression in aged mice identifies ceramide synthase-1 and ceramide synthase-5 as potential regulators of fiber size and strength in skeletal muscle. [PDF]

Aging Cell, 2020
Tosetti B, Brodesser S, Brunn A, Deckert M, Blüher M, Doehner W, Anker SD, Wenzel D, Fleischmann B, Pongratz C, Peters F, Utermöhlen O, Krönke M.   +12 more
europepmc   +3 more sources

Lack of ceramide synthase 5 protects retinal ganglion cells from ocular hypertensive injury. [PDF]

Exp Eye Res
Liu J, Koutalos Y, Fan J.
europepmc   +3 more sources

Ceramide Production Mediates Aldosterone-Induced Human Umbilical Vein Endothelial Cell (HUVEC) Damages. [PDF]

PLoS ONE, 2016
Here, we studied the underlying mechanism of aldosterone (Aldo)-induced vascular endothelial cell damages by focusing on ceramide. We confirmed that Aldo (at nmol/L) inhibited human umbilical vein endothelial cells (HUVEC) survival, and induced ...
Yumei Zhang, Yu Pan, Zhixiang Bian, Peihua Chen, Shijian Zhu, Huiyi Gu, Liping Guo, Chun Hu   +7 more
doaj   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Strawberry seed extract and its major component, tiliroside, promote ceramide synthesis in the stratum corneum of human epidermal equivalents. [PDF]

PLoS ONE, 2018
The activation of peroxisomeproliferator-activated receptor (PPAR) α can stimulate the expression of ceramide-related enzymes, and a major component of strawberry seed extract (SSE) tiliroside enhances the expression of PPARα.
Shogo Takeda, Hiroshi Shimoda, Toru Takarada, Genji Imokawa   +3 more
doaj   +1 more source

EXPRESSION OF DE NOVO CERAMIDE SYNTHESIS IN LOCAL HEART FAT DEPO IN PATIENTS WITH CARDIOVASCULAR DISEASES

Байкальский медицинский журнал, 2023
Introduction. Ceramides are bioactive lipids that are not only structural components of cell membranes, but also second messengers in the transmission of cell signals.
Julia Alexandrovna Dyleva, Olga Victorovna Gruzdeva, Ekaterina Vladimirovna Belik, Evgeniya Gennadievna Uchasova, Anastasia Valerievna Ponasenko, Sergey Vasilevich Ivanov   +5 more
doaj   +1 more source

Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation. [PDF]

PLoS ONE, 2011
BACKGROUND:Evidence indicates that Bax functions as a "lipidic" pore to regulate mitochondrial outer membrane permeabilization (MOMP), the apoptosis commitment step, through unknown membrane elements.
Hyunmi Lee, Jimmy A Rotolo, Judith Mesicek, Tuula Penate-Medina, Andreas Rimner, Wen-Chieh Liao, Xianglei Yin, Govind Ragupathi, Desiree Ehleiter, Erich Gulbins, Dayong Zhai, John C Reed, Adriana Haimovitz-Friedman, Zvi Fuks, Richard Kolesnick   +14 more
doaj   +1 more source