Results 21 to 30 of about 194,964 (167)

Ceramide synthase TLCD3B is a novel gene associated with human recessive retinal dystrophy. [PDF]

Genet Med, 2021
PURPOSE: Previous studies suggest that ceramide is a proapoptotic lipid as high levels of ceramides can lead to apoptosis of neuronal cells, including photoreceptors.
Bertrand RE, Wang J, Xiong KH, Thangavel C, Qian X, Ba-Abbad R, Liang Q, Simões RT, Sampaio SAM, Carss KJ, Lucy Raymond F, Robson AG, Webster AR, Arno G, Porto FBO, Chen R.   +15 more
europepmc   +3 more sources

Strawberry seed extract and its major component, tiliroside, promote ceramide synthesis in the stratum corneum of human epidermal equivalents. [PDF]

PLoS ONE, 2018
The activation of peroxisomeproliferator-activated receptor (PPAR) α can stimulate the expression of ceramide-related enzymes, and a major component of strawberry seed extract (SSE) tiliroside enhances the expression of PPARα.
Shogo Takeda, Hiroshi Shimoda, Toru Takarada, Genji Imokawa   +3 more
doaj   +1 more source

EXPRESSION OF DE NOVO CERAMIDE SYNTHESIS IN LOCAL HEART FAT DEPO IN PATIENTS WITH CARDIOVASCULAR DISEASES

Байкальский медицинский журнал, 2023
Introduction. Ceramides are bioactive lipids that are not only structural components of cell membranes, but also second messengers in the transmission of cell signals.
Julia Alexandrovna Dyleva, Olga Victorovna Gruzdeva, Ekaterina Vladimirovna Belik, Evgeniya Gennadievna Uchasova, Anastasia Valerievna Ponasenko, Sergey Vasilevich Ivanov   +5 more
doaj   +1 more source

LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia

Journal of Lipid Research, 2005
Ceramide is a key bioactive mediator that inhibits surfactant phosphatidylcholine (PtdCho) synthesis in lung epithelia. Ceramide availability is governed by sphingomyelin (SM) hydrolysis, but less is known regarding its de novo synthesis.
Zhiwei Xu, Jiming Zhou, Diann M. McCoy, Rama K. Mallampalli   +3 more
doaj   +1 more source

C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis [PDF]

, 2003
Understanding the regulation of the apoptotic program in neurons by intracellular pathways is currently a subject of great interest. Recent results suggest that c-Jun N-terminal kinases (JNK), mitogen-activated protein kinases and the transcription ...
Brugg, B., Caboche, J., Willaime-Morawek, S., Brami-Cherrier, K., Mariani, J.   +4 more
core   +1 more source

Sphingolipid and ceramide homeostasis : potential therapeutic targets [PDF]

, 2012
Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction.
Smith, Terry, Simon A. Young, Denny, Paul, Young, Simon, Denny, Paul W., Mina, J.G., Mina, John, Denny, P.W., Smith, Terry K., Mina, John G., John G. Mina, Young, S.A., Smith, T.K., Paul W. Denny, Young, Simon A., Terry K. Smith   +15 more
core   +1 more source

Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation. [PDF]

PLoS ONE, 2011
BACKGROUND:Evidence indicates that Bax functions as a "lipidic" pore to regulate mitochondrial outer membrane permeabilization (MOMP), the apoptosis commitment step, through unknown membrane elements.
Hyunmi Lee, Jimmy A Rotolo, Judith Mesicek, Tuula Penate-Medina, Andreas Rimner, Wen-Chieh Liao, Xianglei Yin, Govind Ragupathi, Desiree Ehleiter, Erich Gulbins, Dayong Zhai, John C Reed, Adriana Haimovitz-Friedman, Zvi Fuks, Richard Kolesnick   +14 more
doaj   +1 more source

Lycoperoside H, a Tomato Seed Saponin, Improves Epidermal Dehydration by Increasing Ceramide in the Stratum Corneum and Steroidal Anti-Inflammatory Effect

Molecules, 2021
Tomatoes are widely consumed, however, studies on tomato seeds are limited. In this study, we isolated 11 compounds including saponins and flavonol glycosides from tomato seeds and evaluated their effects on epidermal hydration.
Shogo Takeda, Kenchi Miyasaka, Sarita Shrestha, Yoshiaki Manse, Toshio Morikawa, Hiroshi Shimoda   +5 more
doaj   +1 more source

AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells

Journal of Lipid Research, 2009
Compound C is commonly used as an inhibitor of AMP-activated protein kinase (AMPK), which serves as a key energy sensor in cells. In this study, we found that Compound C treatment of MCF7 cells led to Bax redistribution from the cytoplasm to mitochondria
Junfei Jin, Thomas D. Mullen, Qi Hou, Jacek Bielawski, Alicja Bielawska, Xiaoming Zhang, Lina M. Obeid, Yusuf A. Hannun, Yi-Te Hsu   +8 more
doaj   +1 more source

Ceramide mediates radiation-induced germ cell apoptosis via regulating mitochondria function and MAPK factors in Caenorhabditis elegans

Ecotoxicology and Environmental Safety, 2021
Studies about radiation damage in vivo are very significant for healthy risk assessment as well as cancer radiotherapy. Ceramide as a second messenger has been found to be related to radiation-induced apoptosis. However, the detailed mechanisms in living
Yaning Yang, Guangmin Xu, Yun Xu, Xiaowen Cheng, Shengmin Xu, Shaopeng Chen, Lijun Wu   +6 more
doaj   +1 more source