Results 21 to 30 of about 338,348 (241)

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism [PDF]

Nature Communications, 2018
Specific forms of the lipid ceramide, synthesized by the ceramide synthase enzyme family, are believed to regulate metabolic physiology. Genetic mouse models have established C16 ceramide as a driver of insulin resistance in liver and adipose tissue. C18
N. Turner, X. Y. Lim, H. Toop, B. Osborne, A. Brandon, Elysha N. Taylor, Corrine E. Fiveash, H. Govindaraju, Jonathan D Teo, Holly P. McEwen, Timothy A. Couttas, Stephen M Butler, Abhirup Das, Greg M. Kowalski, C. Bruce, Kyle L. Hoehn, T. Fath, C. Schmitz‐Peiffer, G. Cooney, M. Montgomery, Jonathan C. Morris, A. Don   +21 more
semanticscholar   +5 more sources

Sphingolipid-Induced Programmed Cell Death is a Salicylic Acid and EDS1-Dependent Phenotype in Arabidopsis Fatty Acid Hydroxylase (Fah1, Fah2) and Ceramide Synthase (Loh2) Triple Mutants. [PDF]

Plant Cell Physiol, 2022
Ceramides and long chain bases (LCBs) are plant sphingolipids involved in the induction of plant programmed cell death (PCD). The fatty acid hydroxylase mutant fah1 fah2 exhibits high ceramide levels and moderately elevated LCB levels. Salicylic acid (SA)
König S, Gömann J, Zienkiewicz A, Zienkiewicz K, Meldau D, Herrfurth C, Feussner I.   +6 more
europepmc   +2 more sources

Ceramide Metabolism Regulated by Sphingomyelin Synthase 2 Is Associated with Acquisition of Chemoresistance via Exosomes in Human Leukemia Cells

International Journal of Molecular Sciences, 2022
Ceramide levels controlled by the sphingomyelin (SM) cycle have essential roles in cancer cell fate through the regulation of cell proliferation, death, metastasis, and drug resistance.
Makoto Taniguchi, Kohei Yuyama, Ai Kotani   +2 more
exaly   +2 more sources

Ceramide synthase 4 interferes with replication of influenza virus but is downregulated by infection [PDF]

Journal of Virology
Influenza continues to pose a serious threat to humans. Influenza-host interaction is incompletely understood, requiring identification of host factors that regulate viral pathogenicity.
Kwang Il Jung, Chuan Xia, Savannah McKenna, Ying He, Vijayamahantesh Vijayamahantesh, Jennifer J. Wolf, Bumsuk Hahm   +6 more
doaj   +2 more sources

Glycosylation of ceramide synthase 6 is required for its activity [PDF]

Journal of Lipid Research
Sphingolipids play key roles in membrane structure and cellular signaling. Ceramide synthase (CerS)-generated ceramide is implicated in cellular stress responses and induction of apoptosis.
Alexandra J. Straus, Grace Mavodza, Can E. Senkal   +2 more
doaj   +2 more sources

A tissue-specific screen of ceramide expression in aged mice identifies ceramide synthase-1 and ceramide synthase-5 as potential regulators of fiber size and strength in skeletal muscle. [PDF]

Aging Cell, 2020
Loss of skeletal muscle mass is one of the most widespread and deleterious processes in aging humans. However, the mechanistic metabolic principles remain poorly understood.
Tosetti B, Brodesser S, Brunn A, Deckert M, Blüher M, Doehner W, Anker SD, Wenzel D, Fleischmann B, Pongratz C, Peters F, Utermöhlen O, Krönke M.   +12 more
europepmc   +2 more sources

Protocol for screening inhibitors of the fungal sphingolipid-metabolizing enzyme ceramide synthase [PDF]

STAR Protocols
Summary: Fungal sphingolipids have emerged as potent antifungal targets based on cumulative evidence demonstrating that fungal sphingolipid metabolism is essential to the virulence of pathogenic fungi. Here, we present a protocol to screen for inhibitors
Andy Zhong, Deveney Dasilva, Nivea Pereira de Sa, Jeehyun Karen You, Maurizio Del Poeta   +4 more
doaj   +2 more sources

Lipidomics Suggests a New Role for Ceramide Synthase in Phagocytosis

ACS Chemical Biology, 2018
Phagocytosis is an evolutionarily conserved biological process where pathogens or cellular debris are cleared by engulfing them in a membrane-enclosed cellular compartment called the phagosome.
D. Pathak, Neelay Mehendale, Shubham Singh, R. Mallik, Siddhesh S. Kamat   +4 more
semanticscholar   +3 more sources

Ceramide Synthase 5 Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis and Colon Carcinogenesis and Impairs T-Cell Activation

Cancers, 2020
Ceramide synthase 5 is one of six enzymes that catalyze the production of ceramides from sphingosine or sphinganine. Ceramides are important components of cell membranes and act as signaling molecules.
K. El-Hindi, Sebastian Brachtendorf, J. Hartel, S. Oertel, Kerstin Birod, S. Trautmann, Dominique Thomas, T. Ulshöfer, A. Weigert, O. Utermöhlen, M. Krönke, S. Grösch   +11 more
semanticscholar   +3 more sources

Ceramide Synthase Schlank Is a Transcriptional Regulator Adapting Gene Expression to Energy Requirements

Cell Reports, 2018
Maintenance of metabolic homeostasis requires adaption of gene regulation to the cellular energy state via transcriptional regulators. Here, we identify a role of ceramide synthase (CerS) Schlank, a multiple transmembrane protein containing a catalytic ...
Bernadette Breiden, Kathrin Klee, Julia Sellin   +2 more
exaly   +2 more sources