Results 21 to 30 of about 34,100 (243)

Protocol for screening inhibitors of the fungal sphingolipid-metabolizing enzyme ceramide synthase [PDF]

STAR Protocols
Summary: Fungal sphingolipids have emerged as potent antifungal targets based on cumulative evidence demonstrating that fungal sphingolipid metabolism is essential to the virulence of pathogenic fungi. Here, we present a protocol to screen for inhibitors
Andy Zhong, Deveney Dasilva, Nivea Pereira de Sa, Jeehyun Karen You, Maurizio Del Poeta   +4 more
doaj   +2 more sources

Cannabidiol’s cytotoxicity in pancreatic cancer is induced via an upregulation of ceramide synthase 1 and ER stress [PDF]

Journal of Cannabis Research
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies with a median 5 year-survival rate of 12%. Cannabidiol (CBD) has been found to exhibit antineoplastic potential and may potentiate the anticancer effects of cytotoxic’
Nagina Mangal, Vikash Reebye, Nagy Habib, Mikael H. Sodergren   +3 more
doaj   +2 more sources

Structural basis of the mechanism and inhibition of a human ceramide synthase [PDF]

, 2023
Pascoa TC, Pike AC, Tautermann CS, Chi G, Traub M, Quigley A, Chalk R, Štefanic S, Thamm S, Pautsch A, Carpenter EP, Schnapp G, Sauer DB.   +12 more
europepmc   +2 more sources

Individual lipid alterations at the origin of neuronal Ceramide Synthase defects. [PDF]

PLoS Genet
Ziegler AB, Wesselmann C, Beckschäfer K, Wulf AL, Dhiman N, Soba P, Thiele C, Bauer R, Tavosanis G.   +8 more
europepmc   +2 more sources

Ceramide Synthase 5 [PDF]

, 2020
National Cancer Institute
openalex   +2 more sources

Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity

Haematologica, 2007
Background and Objectives Arsenic trioxide (ATO) is an effective treatment for acute promyelocytic leukemia (APL) and potentially for human T-cell leukemia virus type I (HTLV-I) associated adult T-cell leukemia/lymphoma (ATL). Many cytotoxic drugs induce
Ghassan S. Dbaibo, Youmna Kfoury, Nadine Darwiche, Shoghag Panjarian, Lina Kozhaya, Rihab Nasr, Mazen Abdallah, Olivier Hermine, Marwan El-Sabban, Hugues de Thé, Ali Bazarbachi   +10 more
doaj   +3 more sources

Sphingomyelin synthase SMS2 displays dual activity as ceramide phosphoethanolamine synthase[S] [PDF]

Journal of Lipid Research, 2009
Sphingolipids are vital components of eukaryotic membranes involved in the regulation of cell growth, death, intracellular trafficking, and the barrier function of the plasma membrane (PM).
Philipp Ternes, Jos F.H.M. Brouwers, Joep van den Dikkenberg, Joost C.M. Holthuis   +3 more
doaj   +7 more sources

The lipidomes of <i>C. elegans</i> with mutations in <i>asm-3</i>/acid sphingomyelinase and <i>hyl-2</i>/ceramide synthase show distinct lipid profiles during aging. [PDF]

Aging (Albany NY), 2023
Staab TA, McIntyre G, Wang L, Radeny J, Bettcher L, Guillen M, Peck MP, Kalil AP, Bromley SP, Raftery D, Chan JP.   +10 more
europepmc   +3 more sources

A fluorescent assay for ceramide synthase activity [PDF]

Journal of Lipid Research, 2012
The sphingolipids are a diverse family of lipids with important roles in membrane compartmentalization, intracellular signaling, and cell-cell recognition. The central sphingolipid metabolite is ceramide, formed by the transfer of a variable length fatty
Hyun Joon Kim, Qiao Qiao, Hamish D. Toop, Jonathan C. Morris, Anthony S. Don   +4 more
doaj   +4 more sources

Erratum: Ceramide synthase-4 orchestrates the cell proliferation and tumor growth of liver cancer in vitro and in vivo through the nuclear factor-κB signaling pathway. [PDF]

Oncol Lett, 2021
Chen J, Li X, Ma D, Liu T, Tian P, Wu C.
europepmc   +3 more sources