PLoS ONE, 2021 β-Sitosterol 3-O-d-glucoside (BSG) is known to act as an agonist by binding to estrogen receptors, and estrogen has been reported to enhance the activity of β-glucocerebrosidase, an epidermal ceramide metabolizing enzyme.
Shogo Takeda +3 more
doaj +3 more sources
Ceramide synthase TLCD3B is a novel gene associated with human recessive retinal dystrophy. [PDF]
Genet Med, 2021 Previous studies suggest that ceramide is a proapoptotic lipid as high levels of ceramides can lead to apoptosis of neuronal cells, including photoreceptors.
Bertrand RE +15 more
europepmc +4 more sources
Ceramide synthases expression and role of ceramide synthase-2 in the lung: insight from human lung cells and mouse models. [PDF]
PLoS ONE, 2013 Increases in ceramide levels have been implicated in the pathogenesis of both acute or chronic lung injury models. However, the role of individual ceramide species, or of the enzymes that are responsible for their synthesis, in lung health and disease ...
Irina Petrache +9 more
doaj +5 more sources
Sphingomyelin synthase SMS2 displays dual activity as ceramide phosphoethanolamine synthase[S] [PDF]
Journal of Lipid Research, 2009 Sphingolipids are vital components of eukaryotic membranes involved in the regulation of cell growth, death, intracellular trafficking, and the barrier function of the plasma membrane (PM).
Philipp Ternes +3 more
doaj +8 more sources
Ceramide Synthase 1 Inhibits Brain Metastasis of Non-Small Cell Lung Cancer by Interacting with USP14 and Downregulating the PI3K/AKT/mTOR Signaling Pathway. [PDF]
Cancers (Basel), 2023 Simple Summary Brain metastasis is common in patients with non-small cell lung cancer and is associated with a poor prognosis. Ceramide synthase 1 participates in malignancy development, but its potential role in non-small cell lung cancer brain ...
Xu Y, Pan J, Lin Y, Wu Y, Chen Y, Li H.
europepmc +2 more sources
The Ceramide Synthase Subunit Lac1 Regulates Cell Growth and Size in Fission Yeast. [PDF]
Int J Mol Sci, 2021 Cell division produces two viable cells of a defined size. Thus, all cells require mechanisms to measure growth and trigger cell division when sufficient growth has occurred.
Flor-Parra I +7 more
europepmc +2 more sources
Ceramide synthase 2 deletion decreases the infectivity of HIV-1. [PDF]
J Biol Chem, 2021 The lipid composition of HIV-1 virions is enriched in sphingomyelin (SM), but the roles that SM or other sphingolipids (SLs) might play in the HIV-1 replication pathway have not been elucidated.
Barklis E +11 more
europepmc +2 more sources
Ceramide synthase 2-C24:1 -ceramide axis limits the metastatic potential of ovarian cancer cells. [PDF]
FASEB J, 2021 Regulation of sphingolipid metabolism plays a role in cellular homeostasis, and dysregulation of these pathways is involved in cancer progression. Previously, our reports identified ceramide as an anti‐metastatic lipid.
Zhang X +14 more
europepmc +2 more sources
Overexpression of a ceramide synthase gene,GhCS1, inhibits fiber cell initiation and elongation by promoting the synthesis of ceramides containing dihydroxy LCB and VLCFA [PDF]
Frontiers in Plant Science, 2022 Cotton is an important natural fiber crop worldwide. Cotton fiber cell is regarded as an ideal material for studying the growth and development of plant cells.
Guiming Li +10 more
doaj +2 more sources
Ceramide Synthase 6 Maximizes p53 Function to Prevent Progeny Formation from Polyploid Giant Cancer Cells. [PDF]
Cancers (Basel), 2021 Simple Summary One mechanism that contributes to cancer recurrence is the ability of some malignant cells to temporarily halt cell division and accumulate multiple nuclei that are later released as progeny, which resume cell division.
Lu P +6 more
europepmc +2 more sources