Ceramide Synthase 6: Comparative Analysis, Phylogeny and Evolution [PDF]
Biomolecules, 2018 Ceramide synthase 6 (CerS6, also known as LASS6) is one of the six members of ceramide synthase gene family in humans. Comparisons of CerS6 amino acid sequences and structures as well as of CerS6 gene structures/locations were conducted using data from ...
Roger S. Holmes +2 more
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Downregulation of ceramide synthase 1 promotes oral cancer through endoplasmic reticulum stress [PDF]
International Journal of Oral Science, 2021 C18 ceramide plays an important role in the occurrence and development of oral squamous cell carcinoma. However, the function of ceramide synthase 1, a key enzyme in C18 ceramide synthesis, in oral squamous cell carcinoma is still unclear. The aim of our
Wen Chen +11 more
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Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy
European Journal of Cell Biology, 2023 Different studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer.
Javad Alizadeh +11 more
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Self-Protection against the Sphingolipid Biosynthesis Inhibitor Fumonisin B1 Is Conferred by a
mBio, 2020 Fumonisin (FB) mycotoxins produced by species of the genus Fusarium detrimentally affect human and animal health upon consumption, due to the inhibition of ceramide synthase.
Slavica Janevska +7 more
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Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis [PDF]
Biomedicines, 2023 Horse-derived ceramide (HC), which contains galactosylceramides as its main component, significantly improves skin symptoms when applied topically to patients with atopic dermatitis. We speculated that efficacy resulted from the amelioration of epidermal
Tami Igarashi +4 more
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Overexpression of a ceramide synthase gene,GhCS1, inhibits fiber cell initiation and elongation by promoting the synthesis of ceramides containing dihydroxy LCB and VLCFA [PDF]
Frontiers in Plant Science, 2022 Cotton is an important natural fiber crop worldwide. Cotton fiber cell is regarded as an ideal material for studying the growth and development of plant cells.
Guiming Li +10 more
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PLoS ONE, 2021 β-Sitosterol 3-O-d-glucoside (BSG) is known to act as an agonist by binding to estrogen receptors, and estrogen has been reported to enhance the activity of β-glucocerebrosidase, an epidermal ceramide metabolizing enzyme.
Shogo Takeda +3 more
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Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury [PDF]
Neural Regeneration ResearchMicroglia, the resident monocyte of the central nervous system, play a crucial role in the response to spinal cord injury. However, the precise mechanism remains unclear.
Wei Zhang +8 more
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Ceramide synthase 4 interferes with replication of influenza virus but is downregulated by infection [PDF]
Journal of VirologyInfluenza continues to pose a serious threat to humans. Influenza-host interaction is incompletely understood, requiring identification of host factors that regulate viral pathogenicity.
Kwang Il Jung +6 more
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Glycosylation of ceramide synthase 6 is required for its activity [PDF]
Journal of Lipid ResearchSphingolipids play key roles in membrane structure and cellular signaling. Ceramide synthase (CerS)-generated ceramide is implicated in cellular stress responses and induction of apoptosis.
Alexandra J. Straus +2 more
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