Results 41 to 50 of about 338,348 (241)
Cell Death and Disease, 2021 Global dysregulation of RNA splicing and imbalanced sphingolipid metabolism has emerged as promoters of cancer cell transformation. Here, we present specific signature of alternative splicing (AS) events of sphingolipid genes for each breast cancer ...
Trishna Pani +17 more
semanticscholar +1 more source
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
GLUCOSE STARVATION INDUCED AUTOPHAGY IS A POTENT APOPTOTIC CELL DEATH MECHANISM IN MULTIDRUG RESISTANT HL60/ADR CELLS [PDF]
Assiut Veterinary Medical Journal, 2010 Multidrug resistance in cancer is significantly limits the effectiveness of cancer chemotherapy. The main purpose of the present study is to investigate the role of autophagy induced by glucose starvation in apoptosis induction in multidrug resistant ...
A-B.M. ABDEL-SHAKOR
doaj +1 more source
ROLE OF CERAMIDE IN TRANSFERRIN RECEPTOR MOVEMENT IN THE PLANE OF THE PLASMA MEMBRANE [PDF]
Assiut Veterinary Medical Journal, 2010 After ligation with transferrin (Tf), transferrin receptor (TfR) is aggregated on cell surface in clathrin coated pits and then internalized into the cell.
RANA ALAWADHI, A-B.M. ABDEL-SHAKOR
doaj +1 more source
Ceramide synthases and ceramide levels are increased in breast cancer tissue [PDF]
Carcinogenesis, 2009 Several in vitro studies have correlated dysfunction of the sphingolipid-signaling pathway with promotion of tumor cell growth as well as progression and resistance of tumors to chemotherapeutic agents. As ceramides (Cer) constitute the structural backbones of all sphingolipids, we investigated the endogenous ceramide levels in 43 malignant breast ...
Susanne, Schiffmann +11 more
openaire +2 more sources
Strawberry seed extract and its major component, tiliroside, promote ceramide synthesis in the stratum corneum of human epidermal equivalents. [PDF]
PLoS ONE, 2018 The activation of peroxisomeproliferator-activated receptor (PPAR) α can stimulate the expression of ceramide-related enzymes, and a major component of strawberry seed extract (SSE) tiliroside enhances the expression of PPARα.
Shogo Takeda +3 more
doaj +1 more source
Bcl2L13 is a ceramide synthase inhibitor in glioblastoma [PDF]
Proceedings of the National Academy of Sciences, 2014 Therapy resistance is a major limitation to the successful treatment of cancer. Here, we identify Bcl2-like 13 (Bcl2L13), an atypical member of the Bcl-2 family, as a therapy susceptibility gene with elevated expression in solid and blood cancers, including glioblastoma (GBM).
Samuel A, Jensen +9 more
openaire +2 more sources
Байкальский медицинский журнал, 2023 Introduction. Ceramides are bioactive lipids that are not only structural components of cell membranes, but also second messengers in the transmission of cell signals.
Julia Alexandrovna Dyleva +5 more
doaj +1 more source
Journal of Lipid Research, 2005 Ceramide is a key bioactive mediator that inhibits surfactant phosphatidylcholine (PtdCho) synthesis in lung epithelia. Ceramide availability is governed by sphingomyelin (SM) hydrolysis, but less is known regarding its de novo synthesis.
Zhiwei Xu +3 more
doaj +1 more source
C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis [PDF]
, 2003 Understanding the regulation of the apoptotic program in neurons by intracellular pathways is currently a subject of great interest. Recent results suggest that c-Jun N-terminal kinases (JNK), mitogen-activated protein kinases and the transcription ...
Brugg, B. +4 more
core +1 more source