Results 41 to 50 of about 194,964 (167)

Astrocytic ceramide as possible indicator of neuroinflammation

Journal of Neuroinflammation, 2019
Background Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease dementia (PDD), and frontotemporal lobar dementia (FTLD) are characterized by progressive neuronal loss but differ in their underlying pathological mechanisms ...
Nienke M. de Wit, Sandra den Hoedt, Pilar Martinez-Martinez, Annemieke J. Rozemuller, Monique T. Mulder, Helga E. de Vries   +5 more
doaj   +1 more source

Development of Human Skin Equivalents with Inducible Ceramide Depletion for In Vitro Modeling of Lipid Impairment

JID Innovations
The lipid composition of the epidermis plays a critical role in the skin’s barrier function, and defects in lipid synthesis or assembly can cause a spectrum of skin diseases, ranging from dry skin to severe ichthyoses.
Durotimi O. Dina, Miriam Maiellaro, Emanuela Camera, John T. Connelly   +3 more
doaj   +1 more source

Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity

Haematologica, 2007
Background and Objectives Arsenic trioxide (ATO) is an effective treatment for acute promyelocytic leukemia (APL) and potentially for human T-cell leukemia virus type I (HTLV-I) associated adult T-cell leukemia/lymphoma (ATL). Many cytotoxic drugs induce
Ghassan S. Dbaibo, Youmna Kfoury, Nadine Darwiche, Shoghag Panjarian, Lina Kozhaya, Rihab Nasr, Mazen Abdallah, Olivier Hermine, Marwan El-Sabban, Hugues de Thé, Ali Bazarbachi   +10 more
doaj   +1 more source

Trends in ceramide synthase activities.

, 2015
The upper panel shows ceramide synthase activities toward DHC, while the lower panel shows ceramide synthase activities toward PHC. The X-axis represents the 30 minutes of heat stress and the Y-axis represents fold changes in activities.
Luis L. Fonseca (416505), Po-Wei Chen (416504), Eberhard O. Voit (50265), Yusuf A. Hannun (116276)   +3 more
core   +1 more source

A comprehensive measure of Golgi sphingolipid flux using NBD C6-ceramide: evaluation of sphingolipid inhibitors

Journal of Lipid Research
Measurements of sphingolipid metabolism are most accurately performed by LC-MS. However, this technique is expensive, not widely accessible, and without the use of specific probes, it does not provide insight into metabolic flux through the pathway ...
Allen H. Lee, Justin M. Snider, Sitapriya Moorthi, Nicolas Coant, Magali Trayssac, Daniel Canals, Christopher J. Clarke, Chiara Luberto, Yusuf A. Hannun   +8 more
doaj   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Modeling SMS driven conversion of ceramide to sphingomyelin reveals the existence of a positive feedback mechanism [PDF]

, 2012
In questa tesi presentiamo un modello matematico minimo per la conversione di un ceramide in sfingomielina catalizzata dall'enzima sfingomielina sintasi 1 (SMS1) basato sulle leggi della cinetica chimica.
Thomaseth, Caterina
core  

IGF-I protects cortical neurons against ceramide-induced apoptosis via activation of the PI-3K/Akt and ERK pathways; is this protection independent of CREB and Bcl-2?

, 2005
Current understanding of IGF-I-mediated neuroprotection implies the activation of phosphatidylinositol-3-kinase (PI-3K), which leads to the activation of Akt/Protein Kinase B.
Brugg, B., Arbez, N., Willaime-Morawek, S., Mariani, J.   +3 more
core   +1 more source

Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases

Nature Communications, 2023
Until now, membrane-protein stabilization has relied on iterations of mutations and screening. We now validate a one-step algorithm, mPROSS, for stabilizing membrane proteins directly from an AlphaFold2 model structure.
Iris D. Zelnik, Beatriz Mestre, Jonathan J. Weinstein, Tamir Dingjan, Stav Izrailov, Shifra Ben-Dor, Sarel J. Fleishman, Anthony H. Futerman   +7 more
doaj   +1 more source

Ciliary Membrane Lipid Homeostasis in Health and Disease

Advanced Science, EarlyView.
This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang, Yuan‐yuan Liu, Hanqi Sun, Peiwei Liu   +3 more
wiley   +1 more source