Results 61 to 70 of about 338,348 (241)

Lactosylceramide contributes to mitochondrial dysfunction in diabetes

Journal of Lipid Research, 2016
Sphingolipids have been implicated as key mediators of cell-stress responses and effectors of mitochondrial function. To investigate potential mechanisms underlying mitochondrial dysfunction, an important contributor to diabetic cardiomyopathy, we ...
Sergei A. Novgorodov, Christopher L. Riley, Jin Yu, Jarryd A. Keffler, Christopher J. Clarke, An O. Van Laer, Catalin F. Baicu, Michael R. Zile, Tatyana I. Gudz   +8 more
doaj   +1 more source

Ceramide synthase inhibition by fumonisins: a perfect storm of perturbed sphingolipid metabolism, signaling, and disease[S]

Journal of Lipid Research, 2019
Fumonisins are mycotoxins that cause diseases of plants and, when consumed by animals, can damage liver, kidney, lung, brain, and other organs, alter immune function, and cause developmental defects and cancer.
R. Riley, A. Merrill
semanticscholar   +1 more source

Modulation of Ceramide Synthase Activity via Dimerization [PDF]

Journal of Biological Chemistry, 2012
Ceramide, the backbone of all sphingolipids, is synthesized by a family of ceramide synthases (CerS) that each use acyl-CoAs of defined chain length for N-acylation of the sphingoid long chain base. CerS mRNA expression and enzymatic activity do not always correlate with the sphingolipid acyl chain composition of a particular tissue, suggesting post ...
Elad L, Laviad, Samuel, Kelly, Alfred H, Merrill, Anthony H, Futerman   +3 more
openaire   +2 more sources

Astrocytic ceramide as possible indicator of neuroinflammation

Journal of Neuroinflammation, 2019
Background Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease dementia (PDD), and frontotemporal lobar dementia (FTLD) are characterized by progressive neuronal loss but differ in their underlying pathological mechanisms ...
Nienke M. de Wit, Sandra den Hoedt, Pilar Martinez-Martinez, Annemieke J. Rozemuller, Monique T. Mulder, Helga E. de Vries   +5 more
doaj   +1 more source

Sphingolipid and ceramide homeostasis : potential therapeutic targets

, 2012
Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction.
Smith, Terry, Simon A. Young, Denny, Paul, Young, Simon, Denny, Paul W., Mina, J.G., Mina, John, Denny, P.W., Smith, Terry K., Mina, John G., John G. Mina, Young, S.A., Smith, T.K., Paul W. Denny, Young, Simon A., Terry K. Smith   +15 more
core   +1 more source

Development of Human Skin Equivalents with Inducible Ceramide Depletion for In Vitro Modeling of Lipid Impairment

JID Innovations
The lipid composition of the epidermis plays a critical role in the skin’s barrier function, and defects in lipid synthesis or assembly can cause a spectrum of skin diseases, ranging from dry skin to severe ichthyoses.
Durotimi O. Dina, Miriam Maiellaro, Emanuela Camera, John T. Connelly   +3 more
doaj   +1 more source

Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity

Haematologica, 2007
Background and Objectives Arsenic trioxide (ATO) is an effective treatment for acute promyelocytic leukemia (APL) and potentially for human T-cell leukemia virus type I (HTLV-I) associated adult T-cell leukemia/lymphoma (ATL). Many cytotoxic drugs induce
Ghassan S. Dbaibo, Youmna Kfoury, Nadine Darwiche, Shoghag Panjarian, Lina Kozhaya, Rihab Nasr, Mazen Abdallah, Olivier Hermine, Marwan El-Sabban, Hugues de Thé, Ali Bazarbachi   +10 more
doaj   +1 more source

Trends in ceramide synthase activities.

, 2015
The upper panel shows ceramide synthase activities toward DHC, while the lower panel shows ceramide synthase activities toward PHC. The X-axis represents the 30 minutes of heat stress and the Y-axis represents fold changes in activities.
Luis L. Fonseca (416505), Po-Wei Chen (416504), Eberhard O. Voit (50265), Yusuf A. Hannun (116276)   +3 more
core   +1 more source

A comprehensive measure of Golgi sphingolipid flux using NBD C6-ceramide: evaluation of sphingolipid inhibitors

Journal of Lipid Research
Measurements of sphingolipid metabolism are most accurately performed by LC-MS. However, this technique is expensive, not widely accessible, and without the use of specific probes, it does not provide insight into metabolic flux through the pathway ...
Allen H. Lee, Justin M. Snider, Sitapriya Moorthi, Nicolas Coant, Magali Trayssac, Daniel Canals, Christopher J. Clarke, Chiara Luberto, Yusuf A. Hannun   +8 more
doaj   +1 more source

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source