Results 81 to 90 of about 338,348 (241)

Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis

Scientific Reports, 2018
Colitis, an inflammatory disease of the digestive tract, is increasing in incidence and prevalence. Intestinal inflammation can occur as a consequence of dysfunctions in sphingolipid metabolism. In this study we used ceramide synthase 6 (CerS6) deficient
K. Helke, P. Angel, P. Lu, E. Garrett-Mayer, B. Ogretmen, R. Drake, C. Voelkel-Johnson   +6 more
semanticscholar   +1 more source

Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma

OncoTarget, 2017
Ceramide synthase 1 (CERS1) is the most highly expressed CERS in the central nervous system, and ceramide with an 18-carbon–containing fatty acid chain (C18-ceramide) in the brain plays important roles in signaling and sphingolipid development.
Z. Wang, Lijun Wen, Fei Zhu, Yanping Wang, Qing Xie, Zijun Chen, Yunsen Li   +6 more
semanticscholar   +1 more source

Sleep deprivation aggravates hepatocytes steatosis and insulin resistance by regulating exosomal microRNAs

Interdisciplinary Medicine, EarlyView.
Sleep deprivation accelerates the progression of MASLD and IR by up‐regulating the expression of miR‐3572‐5p and down‐regulating the expression of miR‐183‐5p in circulating exosomes, thereby inhibiting fatty acid β‐oxidation and disrupting insulin signaling pathways. Abstract Sleep deprivation (SD) threatens human health and increases the prevalence of 
Xinxin Xu, Lulu Li, Ying Cao, Ying Wang, Chao Yang, Alexander Nikolaevich Orekhov, Yuanfeng Lu, Houbin Chu, Chuanrong Zhao, Guixue Wang, Guohua Song   +10 more
wiley   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Fetal asphyxia induces acute and persisting changes in the ceramide metabolism in rat brain[S]

Journal of Lipid Research, 2013
Fetal asphyctic preconditioning, induced by a brief episode of experimental hypoxia-ischemia, offers neuroprotection to a subsequent more severe asphyctic insult at birth.
Evi Vlassaks, Chiara Mencarelli, Maria Nikiforou, Eveline Strackx, Maria J. Ferraz, Johannes M. Aerts, Marc H. De Baets, Pilar Martinez-Martinez, Antonio W.D. Gavilanes   +8 more
doaj   +1 more source

Ceramide Synthases Are Attractive Drug Targets for Treating Metabolic Diseases

Frontiers in Endocrinology, 2020
Ceramide synthases (CerS) are central enzymes required for the de-novo synthesis of ceramides and other sphingolipids. They catalyze the addition of different acyl-chains to a sphingoid base, and thus account for much of the rich diversity in the ...
Suryaprakash Raichur
doaj   +1 more source

Lipid Metabolism, Lipogenesis, and Resistance to Third Generation EGFR‐TKIs

Journal of Clinical Laboratory Analysis, EarlyView.
Cancer metabolism has emerged as a critical area of study in cancer research, offering insights into the complex mechanisms underlying tumor growth and development. Lipid metabolic reprogramming, especially the dynamic balance between fatty acid synthesis and fatty acid oxidation, plays significant roles in tumor progression. ABSTRACT Background Cancer
Wenhao Luo, Zun Wang, Guangzhi Ma, Wang Shen, Xiaobo Chen, Yida Liao   +5 more
wiley   +1 more source

The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei

, 2010
Sphingomyelin is the main sphingolipid in Trypanosoma brucei, the causative agent of African sleeping sickness. In vitro and in vivo characterization of the T.
Smith, Terry K., Young, Simon A., Young, Simon Alan   +2 more
core   +1 more source

Rare‐Variant Burden across Lysosomal Genes Implicates Sialylation and Ganglioside Metabolism in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Lysosomal dysfunction is central to Parkinson's disease (PD) pathogenesis, with GBA1 representing the strongest established genetic risk factor. Numerous other genes involved in lysosomal sphingolipid, glycosphingolipid, and ceramide metabolism have been proposed as contributors to PD, highlighting the need for genetic analyses ...
Konstantin Senkevich, Sitki Cem Parlar, Cloe Chantereault, Lang Liu, Eric Yu, Uladzislau Rudakou, Jamil Ahmad, Jennifer A. Ruskey, Farnaz Asayesh, Dan Spiegelman, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupré, Lior Greenbaum, Sharon Hassin‐Baer, Irina Miliukhina, Alla Timofeeva, Anton Emelyanov, Sofya Pchelina, Roy N. Alcalay, Ziv Gan‐Or   +21 more
wiley   +1 more source

Ablation of ceramide synthase 2 exacerbates dextran sodium sulphate‐induced colitis in mice due to increased intestinal permeability

Journal of Cellular and Molecular Medicine, 2017
Ceramides mediate crucial cellular processes including cell death and inflammation and have recently been implicated in inflammatory bowel disease. Ceramides consist of a sphingoid long‐chain base to which fatty acids of various length can be attached ...
Ye-Ryung Kim, Giora Volpert, Kyong-Oh Shin, So-Yeon Kim, S. Shin, Younghay Lee, S. Sung, Yong-Moon Lee, Jung-Hyuck Ahn, Y. Pewzner‐Jung, Woo‐Jae Park, A. Futerman, J. Park   +12 more
semanticscholar   +1 more source