Results 101 to 110 of about 194,964 (167)

Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola

Insect Molecular Biology, Volume 35, Issue 5, Page 576-593, October 2026.
Malaria mosquito antimicrobial defence requires upregulation of lola. Attenuation of lola in the midgut of Anopheles albimanus mosquitoes inhibits the upregulation of immunity genes induced by challenge. Putative target genes of the Lola transcription factor were revealed by lola attenuation, including Cecropin‐C, Draper, PPAF2, Clip‐domain serine ...
Heidi Espadas‐Álvarez, Verónica Valverde‐Garduño   +1 more
wiley   +1 more source

The role of Dlc-2 in ceramide signaling to PGP synthase

, 2010
The purpose of this project was to determine how Dlc-2 and Rho signaling modulate the ceramide induction of PGP synthase. This induction was studied at the transcriptional, post-transcriptional, and post-translational levels using cell culture, Real ...
Shields, Caroline
core  

Seminal Extracellular Vesicles as Molecular Modulators of Male Reproductive Function

Reproduction in Domestic Animals, Volume 61, Issue S3, October 2026.
ABSTRACT Extracellular vesicles (sEVs) contained in seminal plasma (SP) maintain, in concert with free SP‐components (proteins, hormones, cytokines, metabolites and antioxidants) under an endocrine umbrella the functional in vivo homeostasis of ejaculated spermatozoa. The sEVs define a generic mixture of nanovesicles delivered by male epithelial cells,
Heriberto Rodriguez‐Martinez, Jordi Roca, Fernando Peña Vega, Emilio A. Martinez   +3 more
wiley   +1 more source

Acute exercise‐induced lipolysis and increase in levels of fatty acid esters of hydroxy fatty acids in adipose tissue are impaired in obese and aged mice

Experimental Physiology, Volume 111, Issue 10, Page 4457-4497, 1 October 2026.
Abstract Improving adipose tissue (AT) metabolism through exercise might increase production of lipokines from the fatty acid esters of hydroxy fatty acids (FAHFA) family. Although exercise training can increase insulin sensitivity and levels of specific FAHFA in AT and the circulation in humans, the effects of acute exercise on FAHFA levels remain ...
Marko Mitrovic, Olga Horakova, Martin Riecan, Veronika Kleinova, Tomas Cajka, Lenka Rossmeislova, Ondrej Kuda, Martin Rossmeisl   +7 more
wiley   +1 more source

Ablation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytes [PDF]

, 2012
Background: Ceramide synthase 1 catalyzes the synthesis of C18 ceramide and is mainly expressed in neurons of the brain. Results: Ablation of Ceramide Synthase 1 decreases ganglioside levels and expression of oligodendrocytic Myelin Associated ...
Degen, Joachim, Sandhoff, Konrad, Zlomuzica, Armin, Sandhoff, Roger, Ginkel, Christina, Dorp, Katharina Vom, Farwanah, Hany, Dörmann, Peter, Hartmann, Dieter, Rabionet, Mariona, Willecke, Klaus, Eckhardt, Matthias, Dere, Ekrem   +12 more
core  

Determinants of C₁₆-Ceramide Binding to p53

Biomolecules
The tumor suppressor p53 coordinates cellular stress responses, but underlying mechanisms remain incompletely understood. We previously demonstrated that, in response to metabolic stress, C16-ceramide produced by ceramide synthase 6 (CerS6) directly ...
Madeline S. Childress, Kristen A. Jeffries, Sergey A. Krupenko, Natalia I. Krupenko   +3 more
doaj   +1 more source

Molecular insights into fungal inositol phosphorylceramide synthesis and its inhibition by antifungal aureobasidin A

Nature Communications
Fungal inositol phosphorylceramide (IPC) synthase is an essential enzyme complex that catalyzes a critical step in sphingolipid biosynthesis. It is the molecular target of potent antifungal aureobasidin A (AbA).
Jiehui Chen, Yan Ke, Min Zhang, Xinyuan Lin, Zhengkang Hua, Di Zhang, Xinlin Hu, Xuyang Ding, Jiameng Li, Ping Yang, Hongjun Yu   +10 more
doaj   +1 more source

Ceramide synthase 4 overexpression exerts oncogenic properties in breast cancer. [PDF]

Lipids Health Dis, 2023
Kim SJ, Seo I, Kim MH, Park JW, Kim S, Park WJ.   +5 more
europepmc   +1 more source

ORM Expression Alters Sphingolipid Homeostasis and Differentially Affects Ceramide Synthase Activity [PDF]

, 2016
Sphingolipid synthesis is tightly regulated in eukaryotes. This regulation in plants ensures sufficient sphingolipids to support growth while limiting the accumulation of sphingolipid metabolites that induce programmed cell death.
Chen, Ming, Cahoon, Rebecca E., Kimberlin, Athen N, Markham, Jennifer E., Markham, Jonathan E., Kimberlin, Athen N., Dunn, Teresa M., Cahoon, Edgar B., Luttgeharm, Kyle D., Stone, Julie M., Han, Gongshe   +10 more
core  

Lag1p and Lac1p Are Essential for the Acyl-CoA–dependent Ceramide Synthase Reaction in Saccharomyces cerevisae

, 2001
International audienceLag1p and Lac1p are two homologous transmembrane proteins of the endoplasmic reticulum in Saccharomyces cerevisiae. Homologous genes have been found in a wide variety of eukaryotes.
Schorling, D, Vallée, Béatrice, Riezman, Howard, Oesterhelt, Dieter, Barz, Wolfgang   +4 more
core   +1 more source