Results 101 to 110 of about 34,100 (243)
PLoS ONE, 2013 Oxidized phospholipids (OxPLs), including 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine (PGPC) and 1-palmitoyl-2-oxovaleroyl-sn-glycero-3-phosphocholine (POVPC) are among several biologically active derivatives that are generated during oxidation of low-density lipoproteins (LDLs).
Lingaraju M Halasiddappa +3 more
openaire +4 more sources
Lip1p: a novel subunit of acyl‐CoA ceramide synthase [PDF]
The EMBO Journal, 2005 Ceramide plays a crucial role as a basic building block of sphingolipids, but also as a signalling molecule mediating the fate of the cell. Although Lac1p and Lag1p have been shown recently to be involved in acyl-CoA-dependent ceramide synthesis, ceramide synthase is still poorly characterized.
Vallée, Béatrice, Riezman, H.
openaire +3 more sources
Neurobiology of Disease, 2004 We have explored the molecular mechanism underlying amyloid beta-peptide (Aβ)-mediated cytotoxicity in vitro. Exposure of murine cerebral endothelial cells (CECs) or C6 glioma cells to Aβ25-35 resulted in dose-dependent cell death.
Ding-I Yang +4 more
doaj +1 more source
, 2019 In eukaryotic cells, the trans-Golgi network (TGN) serves as a platform for secretory cargo sorting and trafficking. In recent years, it has become evident that a complex network of lipid-lipid and lipid-protein interactions contributes to these key ...
Hausser, A., von Blume, J.
core +1 more source
Ceramides and mitochondrial fatty acid oxidation in obesity [PDF]
, 2017 : Obesity is an epidemic, complex disease that is characterized by increased glucose, lipids, and low-grade inflammation in the circulation, among other factors.
Casals i Farré, Núria +3 more
core +1 more source
Comprehensive DIA‐MS Proteomics of Root Basal Nodes Elucidates Mechanisms of Salt Tolerance in Rice
PROTEOMICS, EarlyView.ABSTRACT Soil salinity severely affects rice growth, yield, and quality, posing a global food security challenge. Rice is particularly vulnerable to high salinity, which restricts growth and tolerance to other stresses. To address this, breeding efforts have been made in the past, leading to the generation of multi‐stress‐tolerant rice lines.
Cheol Woo Min +8 more
wiley +1 more source
Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson's disease
Movement Disorders, 2013 ABSTRACTGenetic studies have provided increasing evidence that ceramide homeostasis plays a role in neurodegenerative diseases including Parkinson's disease (PD). It is known that the relative amounts of different ceramide molecular species, as defined by their fatty acyl chain length, regulate ceramide function in lipid membranes and in signaling ...
Abbott, Sarah +7 more
openaire +4 more sources
Role of ceramide in diabetes mellitus: evidence and mechanisms [PDF]
, 2013 Diabetes mellitus is a metabolic disease with multiple complications that causes serious diseases over the years. The condition leads to severe economic consequences and is reaching pandemic level globally.
Alaa Galadari +4 more
core +1 more source
Precision Medical Sciences, EarlyView.This graphical summary highlights the clinical application of single‐nucleotide polymorphisms‐based risk stratification in coronary artery disease. By integrating polygenic risk with clinical assessment, imaging, and preventive strategies, genetic information enables earlier risk identification, optimized screening, and personalized lifestyle and ...
Li Dai +8 more
wiley +1 more source
Journal of Lipid Research, 2013 Light-induced retinal degeneration (LIRD) in albino rats causes apoptotic photoreceptor cell death. Ceramide is a second messenger for apoptosis. We tested whether increases in ceramide mediate photoreceptor apoptosis in LIRD and if inhibition of ...
Hui Chen +6 more
doaj +1 more source