Results 111 to 120 of about 338,348 (241)

Updates on Mediterranean diet and health status: active ingredients and pharmacological mechanisms

British Journal of Pharmacology, Volume 183, Issue 13, Page 3484-3502, July 2026.
The Mediterranean diet (MedDiet) is among the most extensively studied dietary patterns and has been consistently associated with reduced risk of all‐cause mortality, cardiovascular disease, metabolic disorders, cognitive decline and several types of cancers.
Lukas Schwingshackl, Jakub Morze, Sabina Wallerer, Georg Hoffmann   +3 more
wiley   +1 more source

Left panel: Time series estimates of ceramide synthase activities.

, 2016
Each plot represents the ceramide synthase activities for a specific ceramide species. Gray stars represent individual simulation results and blue lines are averaged simulated activities.
Luis L. Fonseca (416505), Po-Wei Chen (416504), Eberhard O. Voit (50265), Yusuf A. Hannun (116276)   +3 more
core   +1 more source

Synergistic Cytotoxic Effects of Resveratrol in Combination with Ceramide Metabolizing Enzymes in Ph + Acute Lymphoblastic Leukemia

Proceedings, 2017
Bioactive sphingolipids are a lipid family including ceramide, sphingosine-1-phosphate (S1P) and glucosyl ceramide (GC). Ceramide produced through de novo synthesis pathway (Serine Palmitoyl Transferase (SPT) is a key enzyme subjected to regulation ...
Osman Oğuz, Aysun Adan
doaj   +1 more source

Lipid Dynamics in the Amyloid Cascade Hypothesis: Evaluating the Biological Relevance of In Vitro Models

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
This review reconsiders the amyloid cascade by placing lipid dynamics at its core. It shows that free lipids, governed by critical micellar concentration, act as pathological chaperones that redirect amyloid aggregation toward membrane‐damaging species.
Sofia Serravalle, Fabio Lolicato, Carmelo Tempra, Martina Pannuzzo, Michele F. M. Sciacca, Danilo Milardi, Carmelo La Rosa   +6 more
wiley   +1 more source

Visualization of ceramide channels in lysosomes following endogenous palmitoyl-ceramide accumulation as an initial step in the induction of necrosis

Biochemistry and Biophysics Reports, 2017
In this study, we showed that the dual addition of glucosyl ceramide synthase and ceramidase inhibitors to A549 cell culture led to the possibility of ceramide channel formation via endogenous palmitoyl-ceramide accumulation with an increase in ...
Mototeru Yamane, Shota Moriya, Hiroko Kokuba   +2 more
doaj   +1 more source

Cannabigerol Alleviates Obesity‐Induced Mitochondrial Dysfunction by Cardiolipin Fatty Acid Remodeling

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Graphical overview of the effects of the high‐fat, high‐sucrose (HFHS) diet regime and 2‐week cannabigerol (CBG) treatment on the intramuscular long‐chain fatty acids (LCFAs) trafficking and lipid metabolism, with subsequent implications for mitochondrial cardiolipin (CL) composition in the red gastrocnemius muscle.
Patrycja Bielawiec, Karolina Konstantynowicz‐Nowicka, Adrian Chabowski, Ewa Harasim‐Symbor   +3 more
wiley   +1 more source

Protection of C. elegans from anoxia by HYL-2 ceramide synthase

, 2009
Oxygen deprivation is rapidly deleterious for most organisms. However, Caenorhabditis elegans has developed the ability to survive anoxia for at least 48 hours. Mutations in the DAF-2/DAF-16 insulin-like signaling pathway promote such survival.
Fornallaz-Mulhauser, M, Howell, Kate S., Riezman, Howard, Riezman, Isabelle, Hengartner, Michael O., Hengartner, Michael O, Epstein, S, Menuz, V, Gentina, Sébastien, Hengartner, M O, Howell, K S, Gomez, M, Riezman, H, Gomez, Marie, Riezman, I, Fornallaz-Mulhauser, Monique, Martinou, J C, Epstein, Sharon, Menuz, Vincent Régis, Martinou, Jean-Claude, Gentina, S, Howell, Kate S, Menuz, Vincent   +22 more
core   +1 more source

Regulation of primary cilia formation by ceramide[S]

Journal of Lipid Research, 2009
The primary cilium is an important sensory organelle, the regulation of which is not fully understood. We found that in polarized Madin-Darby Canine Kidney cells, the sphingolipid ceramide is specifically distributed to a cis-Golgi compartment at the ...
Guanghu Wang, Kannan Krishnamurthy, Erhard Bieberich   +2 more
doaj   +1 more source

Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity*

Journal of Biological Chemistry, 2016
Ceramides are bioactive sphingolipids, which are composed of sphingoid bases carrying acyl chains of various lengths. Ceramides are synthesized by a family of six ceramide synthases (CerS) in mammals, which produce ceramides with different N-linked acyl ...
Dominic Gosejacob, Philipp S Jäger, Katharina vom Dorp, Martin Frejno, Anne Carstensen, Monika Köhnke, Joachim Degen, P. Dörmann, M. Hoch   +8 more
semanticscholar   +1 more source

Targeting ceramide synthases for the development of new antifungals

Structure
Invasive fungal infections (IFIs) caused by pathogenic fungi are a major public health concern, particularly across various immunocompromised populations. Effective clinical management is currently hindered by limited treatment options. Fungal sphingolipids have emerged as potential antifungal targets based on cumulative evidence demonstrating that ...
Deveney Dasilva, Nivea Pereira de Sa, Kathryn Takemura, Kalani Jayanetti, Jeehyun Karen You, Nathalia Vieira de Sa, Gabriel Soares Matos, Andy Zhong, Can E. Senkal, Yusuf Hannun, Iwao Ojima, John Mallamo, John B. McCarthy, Maurizio Del Poeta   +13 more
openaire   +3 more sources