Results 131 to 140 of about 34,100 (243)

Regulation of primary cilia formation by ceramide[S]

Journal of Lipid Research, 2009
The primary cilium is an important sensory organelle, the regulation of which is not fully understood. We found that in polarized Madin-Darby Canine Kidney cells, the sphingolipid ceramide is specifically distributed to a cis-Golgi compartment at the ...
Guanghu Wang, Kannan Krishnamurthy, Erhard Bieberich   +2 more
doaj   +1 more source

Low serum sphingolipids in children with attention deficit-hyperactivity disorder [PDF]

, 2015
Background: Attention deficit-hyperactivity disorder (ADHD) is the most prevalent neuropsychiatric condition in childhood. ADHD is a multifactorial trait with a strong genetic component. One neurodevelopmental hypothesis is that ADHD is associated with a
Benjamin I Kim, Marcela Patricia Henríquez-Henríquez, Marcela Patricia Henríquez-Henríquez, Richard J. Deckelbaum, Sandra eSolari, Teresa eQuiroga, Tilla S. Worgall   +6 more
core   +2 more sources

The Two Classes of Ceramide Synthases Play Different Roles in Plant Immunity and Cell Death

, 2022
Hongyun Zeng, He‐Nan Bao, Yili Chen, Ding‐Kang Chen, Kun Zhang, Shuai‐Kang Liu, La Yang, Yongkang Li, Nan Yao   +8 more
openalex   +1 more source

Elevated Circulating Ceramides 18:0 and 24:1 as a Risk Factor for Sarcopenia: In Vitro, Animal, and Clinical Evidence

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Ceramides have garnered considerable attention as pro‐aging bioactive lipids implicated in both metabolic dysfunction and musculoskeletal decline. Among these, C18:0 and C24:1 ceramides may play a role in the pathophysiology of sarcopenia, a key manifestation of age‐related deterioration.
So Jeong Park, Ji Yeon Baek, Shibo Wei, Jin Young Lee, Yuna Lee, Sang‐Hoon Lee, Il‐Young Jang, Hyuk Sakong, Hyun Ju Yoo, Hee‐Won Jung, Eunju Lee, Su Jung Kim, Yunju Jo, Kyunggon Kim, Dongryeol Ryu, Beom‐Jun Kim   +15 more
wiley   +1 more source

Quantifying Fluorescently Labeled Ceramide Levels in Human Sarcoma Cell Lines in Response to a Sphingomyelin Synthase Inhibitor

Methods and Protocols, 2019
Sphingolipid metabolism is an important process in sustaining the growth needs of rapidly dividing cancer cells. Enzymes that synthesize sphingolipids have become attractive targets in cancer pharmacology.
Srinath Pashikanti, Farjana Afrin, Trevor C. Meldrum, John L. Stegelmeier, Adriene Pavek, Yashar A. Habashi, Kaniz Fatema, Jared J. Barrott   +7 more
doaj   +1 more source

Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets [PDF]

, 2015
The connection between inflammation and tumourigenesis has been well established. However, the detailed molecular mechanism underlying inflammation-associated tumourigenesis remains unknown because this process involves a complex interplay between immune
Chen, Limin, Geng, Meiyu, Huang, Ming, Jiang, Hualiang, Liang, Zhongjie, Liu, Hong, Lu, Junyan, Luo, Cheng, Shen, Bairong, Spiegel, Sarah, Zeng, Hanlin, Zhang, Hao, Zhang, Liyi   +12 more
core   +2 more sources

Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2‐skewed immune polarization

The Journal of Pathology, Volume 269, Issue 2, Page 232-247, June 2026.
Abstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Mariko Takada, Miho Sashikawa‐Kimura, Yusuke Ohno, Md Razib Hossain, Xiaonan Xie, Kazuhisa Iwabuchi, Mayumi Komine, Mamitaro Ohtsuki, Genji Imokawa   +8 more
wiley   +1 more source

Ceramide displaces cholesterol from lipid rafts and decreases the association of the cholesterol binding protein caveolin-1

Journal of Lipid Research, 2005
Addition of exogenous ceramide causes a significant displacement of cholesterol in lipid raft model membranes. However, whether ceramide-induced cholesterol displacement is sufficient to alter the protein composition of caveolin-enriched lipid raft ...
Cuijuan Yu, Michail Alterman, Rick T. Dobrowsky   +2 more
doaj   +1 more source

Elevated plasma ceramide levels in post-menopausal women: a cross-sectional study. [PDF]

, 2019
Circulating ceramide levels are abnormally elevated in age-dependent pathologies such as cardiovascular diseases, obesity and Alzheimer's disease.
Armirotti, Andrea, Assogna, Francesca, Basit, Abdul, Bossù, Paola, Piomelli, Daniele, Piras, Fabrizio, Realini, Natalia, Sensi, Stefano L, Spalletta, Gianfranco, Vozella, Valentina   +9 more
core   +1 more source

On the role of bioactive sphingolipids and their metabolizing enzymes in cancer [PDF]

, 2017
Ceramide is a family of closely related molecules, which are presumed to be in the center of sphingolipid metabolism. Among sphingolipid metabolites, several ceramide subspecies and sphingosine induce apoptosis, cell cycle arrest and death, whereas ...
Ahmed, Dilruba
core   +1 more source