Results 131 to 140 of about 338,348 (241)

Disrupted sphingolipid metabolism following acute clozapine and olanzapine administration

Journal of Biomedical Science, 2018
Background Second generation antipsychotics (SGAs) induce glucometabolic side-effects, such as hyperglycemia and insulin resistance, which pose a therapeutic challenge for mental illness.
Katrina Weston-Green, Ilijana Babic, Michael de Santis, Bo Pan, Magdalene K. Montgomery, Todd Mitchell, Xu-Feng Huang, Jessica Nealon   +7 more
doaj   +1 more source

The Silent Link: Exploring the Impact of Periodontal Diseases on Head and Neck Carcinogenesis

Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Objectives Oral dysbiosis can accelerate the progression of head and neck squamous cell carcinoma (HNSCC) by fostering a pro‐inflammatory, immunosuppressive, and metabolically altered environment. This narrative review examines the relationships between periodontitis‐associated bacteria and HNSCC, focusing on their impact on oncogenic pathways,
Yashmin Afshar, Nima Rezaei
wiley   +1 more source

The role of Dlc-2 in ceramide signaling to PGP synthase

, 2010
The purpose of this project was to determine how Dlc-2 and Rho signaling modulate the ceramide induction of PGP synthase. This induction was studied at the transcriptional, post-transcriptional, and post-translational levels using cell culture, Real ...
Shields, Caroline
core  

Harnessing Fatty Acid By‐Products for Diabetes Management: Insights From Nutritional and Biological Research

eFood, Volume 7, Issue 3, June 2026.
Bioactive fatty acids from agro‐industrial byproducts are highlighted as a promising avenue for managing diabetes in this review, which aims to develop targeted interventions for optimal utilization and therapeutic benefits. ABSTRACT Diabetes mellitus (DM), influenced by multifaceted factors, creates a complex imbalance within the body. Nutrition plays
Youssef Elouafy, Abdelaali Balahbib, Meriem El Fessikh, Saïd Gharby, Nasreddine El Omari, Waleed Al Abdulmonem, Gokhan Zengin, Abdelhakim Bouyahya   +7 more
wiley   +1 more source

Effects of a Moisturizer and Emollient on the Stratum Corneum Assessed by Confocal Raman Spectroscopy in Patients With and Without Atopic Dermatitis: An Assessor‐Blinded Prospective Cohort Study

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Atopic dermatitis (AD) is characterized by impaired skin barrier function and reduced moisturizing factors. Moisturizers and emollients restore the barrier through distinct mechanisms, but their longitudinal molecular effects on the stratum corneum (SC) are poorly characterized, particularly in barrier‐deficient skin.
Risa Fukuda, Rena Hashimoto, Kyongsun Pak, Hazuki Yasuda, Naoko Mochimaru, Yukio Matsumoto, Megumi Kiuchi, Shiho Uematsu, Kazue Yoshida   +8 more
wiley   +1 more source

Lag1p and Lac1p Are Essential for the Acyl-CoA–dependent Ceramide Synthase Reaction in Saccharomyces cerevisae

, 2001
International audienceLag1p and Lac1p are two homologous transmembrane proteins of the endoplasmic reticulum in Saccharomyces cerevisiae. Homologous genes have been found in a wide variety of eukaryotes.
Schorling, D, Vallée, Béatrice, Riezman, Howard, Oesterhelt, Dieter, Barz, Wolfgang   +4 more
core   +1 more source

Research Progress on Anti‐Inflammatory Adipokine SFRP5‐Mediated Lipid Metabolism and Its Potential Role in Neural Development

Immunity, Inflammation and Disease, Volume 14, Issue 6, June 2026.
ABSTRACT Objective To systematically review the structural features of secreted frizzled‑related protein 5 (SFRP5) and its dual regulation of canonical/non‑canonical Wnt signaling, analyze its association with metabolic disorders, and specifically explore the role and mechanisms of the SFRP5–lipid metabolism axis in neural and optic nerve development ...
Qianfang Jia, Zihan Li, Tianyi Yang, Weihua Yang, Wei Chi   +4 more
wiley   +1 more source

Fatty Acid Metabolism in Health and Cancer: From Fundamental Mechanisms to Therapeutic Application

MedComm, Volume 7, Issue 6, June 2026.
The modulation of the TME by fatty acid metabolism primarily occurs through four key pathways: inflammation regulation, signal transduction, translation to TME, and oxidative stress. ABSTRACT Fatty acid metabolism (FAM) plays a vital role in maintaining health by supporting energy production, cellular structure, and signaling processes.
Na Hang, Runkang Zhao, Fan Zhang, Dandan Guo, Qing Li, Zhijun Shen, Ruiqing Gao, Chenyu Gao, Zhao Xie, Sentao Fu, Peng Luo, Bufu Tang, Ling Wang   +12 more
wiley   +1 more source

Organoids: From Bench to Bedside Applications

MedComm, Volume 7, Issue 6, June 2026.
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li, Rui Cao, Maochen Li, Zichao Tian, Huahao Fan, Bixia Hong, Xiaojuan Liu   +6 more
wiley   +1 more source

Characterisation of the first specific inhibitor of ceramide synthase 1

, 2018
The signalling lipid ceramide has been implicated in the pathogenesis of obesity-related insulin resistance. Ceramide is synthesized by a family of six ceramide synthases in mammals (CerS1-6), each of which preferentially utilises fatty acids of ...
Lim, Xin Ying
core   +1 more source