Results 151 to 160 of about 34,100 (243)

Reduced ceramide synthase 2 activity causes progressive myoclonic epilepsy

Annals of Clinical and Translational Neurology, 2014
Ceramides are precursors of complex sphingolipids (SLs), which are important for normal functioning of both the developing and mature brain. Altered SL levels have been associated with many neurodegenerative disorders, including epilepsy, although few direct links have been identified between genes involved in SL metabolism and epilepsy.We used ...
Mosbech, Mai-Britt, Olsen, Anne S B, Neess, Ditte, Ben-David, Oshrit, Klitten, Laura L, Larsen, Jan, Sabers, Anne, Vissing, John, Nielsen, Jørgen E, Hasholt, Lis, Klein, Andres D, Tsoory, Michael M, Hjalgrim, Helle, Tommerup, Niels, Futerman, Anthony H, Møller, Rikke S, Færgeman, Nils J   +16 more
openaire   +4 more sources

Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence. [PDF]

, 2019
Although aging is considered to be an unavoidable event, recent experimental evidence suggests that the process can be counteracted. Intracellular calcium (Ca2+i) dyshomeostasis, mitochondrial dysfunction, oxidative stress, and lipid dysregulation are ...
Bomba, Manuela, Castelli, Vanessa, Cicalini, Ilaria, Cimini, Annamaria, d'Aurora, Marco, Del Boccio, Piero, Gatta, Valentina, Granzotto, Alberto, Massetti, Noemi, Navarra, Riccardo, Onofrj, Marco, Piomelli, Daniele, Sensi, Stefano L   +12 more
core  

Supplementary Figures 1-11 from PERK–Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in <i>mda</i>-7/IL-24–Induced Killing of Primary Human Glioblastoma Multiforme Cells

, 2023
Adly Yacoub, Hossein A. Hamed, Jeremy C. Allegood, Clint Mitchell, Sarah Spiegel, Maciej S. Lesniak, Besim Öğretmen, Rupesh Dash, Devanand Sarkar, William C. Broaddus, Steven Grant, David T. Curiel, Paul B. Fisher, Paul Dent   +13 more
openalex   +2 more sources

Is AMP‐activated protein kinase activation a central mechanism of cardio‐metabolic outcomes after metabolic and bariatric surgery?

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3480-3490, May 2026.
Abstract Metabolic and bariatric surgery (MBS) is the most effective treatment for severe obesity. It usually results in spectacular weight loss, associated with improvements of obesity‐associated comorbidities. The mechanisms underlying these benefits are not fully understood but could involve a postoperative activation of the enzyme 5′ AMP‐activated ...
Adrien Delcour, Nathalie Niederhoffer
wiley   +1 more source

SIRT3 Deacetylates Ceramide Synthases [PDF]

Journal of Biological Chemistry, 2016
Sergei A. Novgorodov, Christopher L. Riley, Jarryd A. Keffler, Jin Yu, Mark S. Kindy, Wendy B. Macklin, David B. Lombard, Tatyana I. Gudz   +7 more
openaire   +1 more source

From Adipose Tissue to Cardiac Repair: Extracellular Vesicles in Cardiovascular Regeneration

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Adipose‐derived extracellular vesicles (ADEVs) secreted by adipose tissue have gained increasing attention due to their regenerative and immunomodulatory properties in cardiovascular diseases. They carry proteins, lipids, and nucleic acids that mediate intercellular communication and influence cardiac pathophysiology. In atherosclerosis, ADEVs
Karolina Ignaczak, Pola Ochocka, Karol Sadowski, Weronika Ploch, Dominika Tomkiel, Mariusz Tomaniak, Wioletta Olejarz   +6 more
wiley   +1 more source

PHR1 mediates rapid high light responses and acclimation to high photosynthetic activity

The Plant Journal, Volume 126, Issue 3, May 2026.
SUMMARY Changing light intensity requires immediate metabolic adjustment which involves reprogramming of both plastidial and nuclear gene expression, but the signaling pathways behind such responses are not fully understood. Here we report that an increase in light intensity causes fluctuations of Pi levels in the chloroplasts of Arabidopsis thaliana ...
Lukas Ackermann, Agnes Fekete, Laura Schröder, Thomas Nägele, Alina J. Hieber, Monika Müller, Martin J. Mueller, Maria Klecker   +7 more
wiley   +1 more source

Ceramide synthases in mammalians, worms, and insects: emerging schemes [PDF]

, 2010
André Voelzmann, Reinhard Bauer
openalex   +1 more source

Loss of ceramide synthase 5 reduces the development of aortic valve stenosis in mice with high fat diet [PDF]

, 2022
Laurine Reese, L Haenschke, Sven Thomas Niepmann, Marija Bulić, P Duesing, Sebastian Zimmer, G Nickenig, Reinhard Bauer, Felix Jansen, Andreas Zietzer   +9 more
openalex   +1 more source

Structure and mechanism of a eukaryotic ceramide synthase complex. [PDF]

EMBO J, 2023
Xie T, Fang Q, Zhang Z, Wang Y, Dong F, Gong X.   +5 more
europepmc   +1 more source