Results 121 to 130 of about 34,100 (243)

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

The effects of rosmarinic acid and carnosic acid on cell viability and ceramide metabolism in the HEP-G2 cells

یافته‌های نوین در علوم زیستی, 2016
Carnosic acid and Rosmarinic acid are family of polyphenols that are found in Rosmary plant. They have property biological behaviors such as anti-cancer, anti-viral and anti-oxidants.
Narges Najjarpour, Masoud Mashadi Akbar Boujar   +1 more
doaj  

A review of skin microbiome and new challenges to cosmetic microbiome‐friendly formulations

International Journal of Cosmetic Science, EarlyView.
Microbiome‐friendly concepts offer new perspectives for a healthy relationship between cosmetic use and the skin microbiome, especially the interaction of non‐biotic cosmetic ingredients with the skin, requiring further studies to clarify the dynamics between the skin microbiome and different classes of cosmetic ingredients.
Yasmin Rosa Santos, Newton Andréo‐Filho, Patricia Santos Lopes, Vânia Rodrigues Leite‐Silva   +3 more
wiley   +1 more source

Endocannabinoid system and anticancer properties of cannabinoids [PDF]

, 2016
Cannabinoids impact human body by binding to cannabinoids receptors (CB1 and CB2). The two main phytocannabinoids are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD).
Nowak, Agnieszka, Słomski, Ryszard, Zeyland, Joanna, Śledziński, Paweł   +3 more
core   +2 more sources

Synergistic Cytotoxic Effects of Resveratrol in Combination with Ceramide Metabolizing Enzymes in Ph + Acute Lymphoblastic Leukemia

Proceedings, 2017
Bioactive sphingolipids are a lipid family including ceramide, sphingosine-1-phosphate (S1P) and glucosyl ceramide (GC). Ceramide produced through de novo synthesis pathway (Serine Palmitoyl Transferase (SPT) is a key enzyme subjected to regulation ...
Osman Oğuz, Aysun Adan
doaj   +1 more source

PDE5 Inhibitors Enhance Celecoxib Killing in Multiple Tumor Types [PDF]

, 2015
The present studies determined whether clinically relevant phosphodiesterase 5 (PDE5) inhibitors interacted with a clinically relevant NSAID, celecoxib, to kill tumor cells.
Bastos-Pereira, Benavides, Booth, Booth, Bruzziches, Carón, Chandrasekharan, Chen, Chen, Choi, Chuang, Cremesti, Cruickshanks, Das, Das, Eberle, Florio, Flower, Formelli, Francis, Gandelman, Giannini, González, Grösch, Hamed, Hayden, Holliday, Hsieh, Hsu, Huang, Johnson, Kardosh, Kern, Kim, Komalavilas, Kots, Liu, Mao, Nandakishore, Nichols, Oh, Park, Park, Pilane, Piplani, Pyrko, Rabkin, Ramer, Reinehr, Roberts, Russwurm, Saba, Sabichi, Schiffmann, Schiffmann, Shen, Shin, Soh, Song, Swiergiel, Tang, Tripathi, Tsutsumi, Veronesi, Vosooghi, Wang, Watanabe, Werner, Williams, Yacoub, Yu   +70 more
core   +2 more sources

Metabolic Enzyme MeHNL11 Regulates MeCAS1b Transcription for Cyanide Reutilization in Response to Nitrate Deficiency in Cassava

Plant Biotechnology Journal, EarlyView.
ABSTRACT Cassava (Manihot esculenta Crantz) exhibits exceptional tolerance to infertile soils and contains abundant cyanogenic glucosides (CGs). Previous research has indicated that CGs can serve as a significant reservoir of organic nitrogen in plants.
Weitao Mai, Ruxue Bao, Xiaocheng Liu, Mengtao Li, Jinling Zhao, Huaifang Zhang, Yuan Yao, Haiyan Wang, Wenquan Wang, Changying Zeng, Xin Chen   +10 more
wiley   +1 more source

Visualization of ceramide channels in lysosomes following endogenous palmitoyl-ceramide accumulation as an initial step in the induction of necrosis

Biochemistry and Biophysics Reports, 2017
In this study, we showed that the dual addition of glucosyl ceramide synthase and ceramidase inhibitors to A549 cell culture led to the possibility of ceramide channel formation via endogenous palmitoyl-ceramide accumulation with an increase in ...
Mototeru Yamane, Shota Moriya, Hiroko Kokuba   +2 more
doaj   +1 more source

Immune Response Modulation by Tumor-Secreted Glycosphingolipids [PDF]

, 2014
Although originally considered merely structural components of cellular membranes, glycosphingolipids (GSL) arenow recognized as having critical effects on cellular physiology, including proliferation, differentiation, viraltransformation and ontogenesis.
Cely, Ingrid, Lardone, Ricardo Dante, Lee, Delphine, Sieling, Peter A.   +3 more
core   +1 more source

The Silent Link: Exploring the Impact of Periodontal Diseases on Head and Neck Carcinogenesis

Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Objectives Oral dysbiosis can accelerate the progression of head and neck squamous cell carcinoma (HNSCC) by fostering a pro‐inflammatory, immunosuppressive, and metabolically altered environment. This narrative review examines the relationships between periodontitis‐associated bacteria and HNSCC, focusing on their impact on oncogenic pathways,
Yashmin Afshar, Nima Rezaei
wiley   +1 more source