Results 11 to 20 of about 64,062 (299)

Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells. [PDF]

Journal of Experimental Medicine, 2005
Lipid raft membrane compartmentalization and membrane-associated guanylate kinase (MAGUK) family molecular scaffolds function in establishing cell polarity and organizing signal transducers within epithelial cell junctions and neuronal synapses. Here, we
Miceli, M Carrie, Patel, Viresh, Round, June L, Schoenberger, Stephen P, Tomassian, Tamar, Zhang, Min   +5 more
core   +2 more sources

Role of membrane microdomains in compartmentation of cAMP signaling. [PDF]

PLoS ONE, 2014
Spatially restricting cAMP production to discrete subcellular locations permits selective regulation of specific functional responses. But exactly where and how cAMP signaling is confined is not fully understood.
Shailesh R Agarwal, Pei-Chi Yang, Monica Rice, Cherie A Singer, Viacheslav O Nikolaev, Martin J Lohse, Colleen E Clancy, Robert D Harvey   +7 more
doaj   +1 more source

HHcy Induces Pyroptosis and Atherosclerosis via the Lipid Raft-Mediated NOX-ROS-NLRP3 Inflammasome Pathway in apoE^−/− Mice

Cells, 2022
Lipid rafts play important roles in signal transduction, particularly in responses to inflammatory processes. The current study aimed to identify whether lipid raft-mediated inflammation contributes to hyperhomocysteinemia (HHcy)-accelerated ...
Sijun Liu, Jun Tao, Fengqi Duan, Huangjing Li, Hongmei Tan   +4 more
doaj   +1 more source

Generation of stable lipid raft microdomains in the enterocyte brush border by selective endocytic removal of non-raft membrane. [PDF]

PLoS ONE, 2013
The small intestinal brush border has an unusually high proportion of glycolipids which promote the formation of lipid raft microdomains, stabilized by various cross-linking lectins. This unique membrane organization acts to provide physical and chemical
E Michael Danielsen, Gert H Hansen
doaj   +1 more source

Comprehensive bioinformatic analyses of KRAS mutations and deciphering chromatin modification landscape of Caveolin-1 gene by lipid raft destabilization induced modulation of RAS-MAPK axis in colon cancer

Advances in Cancer Biology - Metastasis, 2022
Ras signaling contributes to multiple components of cellular functions. To gain insight into the role of KRAS mutant isoforms, we bioinformatically analyzed and noticed that KRAS mutations at G12V, G12D, and G13D positions are prominent in colorectal ...
Ankan Roy, Moonmoon Deb, Niharika, Sabnam Parbin, Arunima Shilpi, Samir Kumar Patra   +5 more
doaj   +1 more source

Alterations of membrane curvature during influenza virus budding [PDF]

, 2014
Influenza A virus belongs to the Orthomyxoviridae family. It is an enveloped virus that contains a segmented and negative-sense RNA genome. Influenza A viruses cause annual epidemics and occasional major pandemics, are a major cause of morbidity and ...
Agnieszka Martyna, Ali, Brown, Bruce, Chen, Enami, Gomez-Puertas, Jeremy Rossman, Johnson, Lai, Leser, Liao, Liu, McCown, McCown, Palese, Pattnaik, Pinto, Rossman, Rossman, Rossman, Rossman, Ruigrok, Schmidt, Takeda, Wang, Wang, Watanabe, Zebedee, Zhang   +29 more
core   +1 more source

Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity [PDF]

, 2009
L1-CAM (L1 cell-adhesion molecule), or more simply L1, plays an important role in the progression of human carcinoma. Overexpression promotes tumour-cell invasion and motility, growth in nude mice and tumour metastasis.
Riedle, Svenja, Kiefel, Helena, Gast, Daniela, Bondong, Sandra, Wolterink, Silke, Gutwein, Paul, Altevogt, Peter   +6 more
core   +2 more sources

UL11 Protein Is a Key Participant of the Duck Plague Virus in Its Life Cycle

Frontiers in Microbiology, 2022
Tegument protein UL11 plays a critical role in the life cycle of herpesviruses. The UL11 protein of herpesviruses is important for viral particle entry, release, assembly, and secondary envelopment.
Linjiang Yang, Linjiang Yang, Linjiang Yang, Mingshu Wang, Mingshu Wang, Mingshu Wang, Anchun Cheng, Anchun Cheng, Anchun Cheng, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Juan Huang, Juan Huang, Juan Huang, Bin Tian, Bin Tian, Renyong Jia, Renyong Jia, Renyong Jia, Mafeng Liu, Mafeng Liu, Mafeng Liu, Dekang Zhu, Dekang Zhu, Shun Chen, Shun Chen, Shun Chen, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Xumin Ou, Xumin Ou, Xumin Ou, Sai Mao, Sai Mao, Sai Mao, Qun Gao, Qun Gao, Qun Gao, Di Sun, Di Sun, Di Sun, Yanlin Yu, Yanlin Yu, Yanlin Yu, Ling Zhang, Ling Zhang, Ling Zhang   +54 more
doaj   +1 more source

Sesquiterpene Alcohol Cedrol Chemosensitizes Human Cancer Cells and Suppresses Cell Proliferation by Destabilizing Plasma Membrane Lipid Rafts

Frontiers in Cell and Developmental Biology, 2021
Chemosensitization of cancer cells with small molecules may improve the therapeutic index of antitumoral agents by making tumor cells sensitive to the drug regimen and thus overcome the treatment resistance and side effects of single therapy.
Siddhartha Kumar Mishra, Siddhartha Kumar Mishra, Siddhartha Kumar Mishra, Yun Soo Bae, Yong-Moon Lee, Jae-Sung Kim, Seung Hyun Oh, Hwan Mook Kim   +7 more
doaj   +1 more source

Manipulation of lipid rafts in neuronal cells [PDF]

, 2010
Lipid rafts are specialized plasma membrane micro-domains highly enriched in cholesterol, sphingolipids and glycosylphosphatidylinositol (GPI) anchored proteins.
Eckert, Gunter P.
core   +1 more source