Results 21 to 30 of about 34,012 (255)

Lenalidomide induces lipid raft assembly to enhance erythropoietin receptor signaling in myelodysplastic syndrome progenitors. [PDF]

PLoS ONE, 2014
Anemia remains the principal management challenge for patients with lower risk Myelodysplastic Syndromes (MDS). Despite appropriate cytokine production and cellular receptor display, erythropoietin receptor (EpoR) signaling is impaired.
Kathy L McGraw, Ashley A Basiorka, Joseph O Johnson, Justine Clark, Gisela Caceres, Eric Padron, Ruth Heaton, Yukiyasu Ozawa, Sheng Wei, Lubomir Sokol, Alan F List   +10 more
doaj   +1 more source

Impairment of Membrane Lipid Homeostasis by Bichalcone Analog TSWU-BR4 Attenuates Function of GRP78 in Regulation of the Oxidative Balance and Invasion of Cancer Cells

Cells, 2020
The specialized cholesterol/sphingolipid-rich membrane domains termed lipid rafts are highly dynamic in the cancer cells, which rapidly assemble effector molecules to form a sorting platform essential for oncogenic signaling transduction in response to ...
Tsung-Lin Lee, Shyang-Guang Wang, Wen-Ling Chan, Ching-Hsiao Lee, Tian-Shung Wu, Meng-Liang Lin, Shih-Shun Chen   +6 more
doaj   +1 more source

A Patching and Coding Lipid Raft-Localized Universal Imaging Platform [PDF]

Chem Biomed Imaging
Xiaomin Yan, Haiqi Wang, Ran Xie
exaly   +2 more sources

Hematopoiesis is regulated by cholesterol efflux pathways and lipid rafts: connections with cardiovascular diseases

Journal of Lipid Research, 2020
Lipid rafts are highly ordered regions of the plasma membrane that are enriched in cholesterol and sphingolipids and play important roles in many cells.
Pooranee K. Morgan, Longhou Fang, Graeme I. Lancaster, Andrew J. Murphy   +3 more
doaj   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Compartmentalized cAMP Signaling Associated With Lipid Raft and Non-raft Membrane Domains in Adult Ventricular Myocytes

Frontiers in Pharmacology, 2018
Aim: Confining cAMP production to discrete subcellular locations makes it possible for this ubiquitous second messenger to elicit unique functional responses.
Shailesh R. Agarwal, Jackson Gratwohl, Mia Cozad, Pei-Chi Yang, Colleen E. Clancy, Robert D. Harvey   +5 more
doaj   +1 more source

Host Lipid Rafts Play a Major Role in Binding and Endocytosis of Influenza A Virus

Viruses, 2018
Influenza still remains one of the most challenging diseases, posing a significant threat to public health. Host lipid rafts play a critical role in influenza A virus (IAV) assembly and budding, however, their role in polyvalent IAV host binding and ...
Dileep Kumar Verma, Dinesh Gupta, Sunil Kumar Lal   +2 more
doaj   +1 more source

Differential Association of the Na+/H+ Exchanger Regulatory Factor (NHERF) Family of Adaptor Proteins with the Raft- and the Non-Raft Brush Border Membrane Fractions of NHE3

Cellular Physiology and Biochemistry, 2013
Background/Aims: Trafficking, brush border membrane (BBM) retention, and signal-specific regulation of the Na+/H+ exchanger NHE3 is regulated by the Na+/H+ Exchanger Regulatory Factor (NHERF) family of PDZ-adaptor proteins, which enable the formation of ...
Ayesha Sultan, Min Luo, Qin Yu, Brigitte Riederer, Weiliang Xia, Mingmin Chen, Simone Lissner, Johannes E. Gessner, Mark Donowitz, C. Chris Yun, Hugo deJonge, Georg Lamprecht, Ursula Seidler   +12 more
doaj   +1 more source

Cafs-Derived Ffa Promotes Oral Cancer By Lipid Raft Synthesis

International Dental Journal
Aim or purpose: Cancer-associated fibroblasts (CAFs) are critical for oral squamous cell carcinoma (OSCC) progression. Given that CAFs display elevated lipid metabolic activity and secrete free fatty acids (FFA) to support tumor cells.
Fanglong Wu, Hongmei Zhou, Shimeng Wang, Jingtian Mu, Tingpei Ye   +4 more
doaj   +1 more source

Aggregation of lipid rafts activates c-met and c-Src in non-small cell lung cancer cells

BMC Cancer, 2018
Background Activation of c-Met, a receptor tyrosine kinase, induces radiation therapy resistance in non-small cell lung cancer (NSCLC). The activated residual of c-Met is located in lipid rafts (Duhon et al. Mol Carcinog 49:739-49, 2010).
Juan Zeng, Heying Zhang, Yonggang Tan, Cheng Sun, Yusi Liang, Jinyang Yu, Huawei Zou   +6 more
doaj   +1 more source