Results 41 to 50 of about 639,057 (242)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Transmembrane Domain Length of Influenza a Virus M2 Does Not Determine Its Non-Lipid Raft Localization

Viruses
Influenza A virus expresses three envelope proteins, hemagglutinin (HA), neuraminidase (NA), and matrix protein 2 (M2). Of these, HA and NA associate with lipid rafts, whereas M2 remains in the peri-raft region.
Rashid Manzoor, Kosuke Okuya, Reiko Yoshida, Hiroko Miyamoto, Ayato Takada   +4 more
doaj   +1 more source

Lipid rafts as a therapeutic target

Journal of Lipid Research, 2020
Lipid rafts regulate the initiation of cellular metabolic and signaling pathways by organizing the pathway components in ordered microdomains on the cell surface. Cellular responses regulated by lipid rafts range from physiological to pathological, and the success of a therapeutic approach targeting "pathological" lipid rafts depends on the ability of ...
Dmitri Sviridov, Nigora Mukhamedova, Yury I. Miller   +2 more
openaire   +3 more sources

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Lipid Raft is required for PSGL-1 ligation induced HL-60 cell adhesion on ICAM-1. [PDF]

PLoS ONE, 2013
P-selectin glycoprotein ligand-1 (PSGL-1) and integrins are adhesion molecules that play critical roles in host defense and innate immunity. PSGL-1 mediates leukocyte rolling and primes leukocytes for integrin-mediated adhesion.
Tingshuang Xu, Wenai Liu, Jixian Luo, Chunfeng Li, Xueqing Ba, Khamal Kwesi Ampah, Xiaoguang Wang, Yong Jiang, Xianlu Zeng   +8 more
doaj   +1 more source

Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol [PDF]

, 2010
We previously showed that macrophages from macrophage-specifi c ATP-binding cassette transporter A1 (ABCA1) knockout (Abca1(-M/-M)) mice had an enhanced proinflammatory response to the Toll-like receptor (TLR) 4 agonist, lipopolysaccharide (LPS ...
Parks, John S., John S. Parks, Zhu, Xuewei, Wilson, Martha D., Xuewei Zhu, Michael J. Thomas, Elizabeth M. Hiltbold, Michael B. Fessler, Gary L. Griffiths, Thomas, Michael J., Hiltbold, Elizabeth M., Haitao Li, John S. Owen, Griffiths, Gary L., Martha D. Wilson, Owen, John S., Li, Haitao, Fessler, Michael B.   +17 more
core   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Pharmacological tools to modulate ordered membrane domains and order-dependent protein function

Communications Chemistry
Ordered membrane nanodomains colloquially known as “lipid rafts” have many proposed cellular functions. However, pharmacological tools to modulate protein affinity for rafts and to manipulate raft formation are currently lacking. We screened 24,000 small
Katherine M. Stefanski, Hui Huang, Dustin D. Luu, Geoffrey C. Li, James M. Hutchison, Nilabh Saksena, Alexander J. Fisch, Thomas P. Hasaka, Joshua A. Bauer, Anne K. Kenworthy, Wade D. Van Horn, Charles R. Sanders   +11 more
doaj   +1 more source

Lipid-rafts remain stable even after ionizing radiation induced disintegration of β1 integrin containing focal adhesions

BMC Research Notes, 2017
Objective Adhesion of cells to the extracellular matrix is facilitated by integrin receptors. We recently found that a nanoscale organization of plasma membrane located integrins containing the β1 subunit is responsible for an enhanced radio-resistance ...
Laura Babel, Larissa Kruse, Steven Bump, Markus Langhans, Tobias Meckel   +4 more
doaj   +1 more source