Results 61 to 70 of about 639,057 (242)

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

RaftProt: mammalian lipid raft proteome database [PDF]

, 2014
RaftProt (http://lipid-raft-database.di.uq.edu.au/) is a database of mammalian lipid raft-associated proteins as reported in high-throughput mass spectrometry studies.
Davis, MJ, Hill, MM, Foster, LJ, Boda, Akash R., Foster, Leonard J, Davis, Melissa J., Shah, A, Shah, Anup, Davis, Melissa J, Chen, David, Foster, Leonard J., Chen, D, Boda, Akash R, Hill, Michelle M., Hill, Michelle M, Boda, AR   +15 more
core   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Expansion Microscopy Reveals the Spatial Association of Therapeutic Antibody–Receptor Complexes With Cholesterol‐Rich Membrane Domains

Angewandte Chemie, EarlyView.
We report a super‐resolution strategy that maps cholesterol‐rich membrane domains in whole, intact cells with an effective spatial resolution of ∼40 nm by combining expansion microscopy with a perfringolysin O domain 4 probe. This approach enables direct visualization of the spatial association between CD20 and CD38 complexes and cholesterol‐rich ...
Gang Wen, Nicole Seifert, Patrick Eiring, Johanna Meyer, Hannes Neuweiler, Julia Weingart, Ignacio Vega‐Vásquez, Sören Doose, Philip Kollmannsberger, Markus Sauer   +9 more
wiley   +2 more sources

Raft-like lipid microdomains drive autophagy initiation via AMBRA1-ERLIN1 molecular association within MAMs

, 2020
Mitochondria-associated membranes (MAMs) are essential communication subdomains of the endoplasmic reticulum (ER) that interact with mitochondria. We previously demonstrated that, upon macroautophagy/autophagy induction, AMBRA1 is recruited to the BECN1 ...
Paola Matarrese (255346), Gian Maria Fimia (431159), Tiziana Vescovo (6877739), Tina Garofalo (255366), Manuela Antonioli (6561800), Agostina Longo (265419), Gloria Riitano (6455414), Christine Gretzmeier (1874908), Serena Recalchi (9504244), Antonella Capozzi (422859), Joern Dengjel (1754890), Maurizio Sorice (18970), Valeria Manganelli (255349), Walter Malorni (147815), Roberta Misasi (255362), Lucrezia Gambardella (147793)   +15 more
core   +1 more source

Integrative analysis of subcellular quantitative proteomics studies reveals functional cytoskeleton membrane-lipid raft interactions in cancer [PDF]

, 2015
Lipid rafts are dynamic membrane microdomains that orchestrate molecular interactions and are implicated in cancer development. To understand the functions of lipid rafts in cancer, we performed an integrated analysis of quantitative lipid raft ...
Davis, MJ, Kerry L. Inder, Hill, M.M., Cristino, Alexandre S, Gabra, H, Arthur B. McKie, Shah, Anup D., Cristino, A.S., Shah, Alok K, Anup D. Shah, Shah, A.K., Kerry L. Inder (3096597), Shah, Anup D, Gabra, H., Davis, Melissa J., Alexandre S. Cristino (223587), Alexandre S. Cristino, Arthur B. McKie (3096591), Hill, Michelle M., Cristino, AS, Inder, Kerry L, Inder, K.L., Davis, M.J., Hill, MM, Alok K. Shah (3096594), Shah, AK, Cristino, Alexandre S., Inder, KL, McKie, Arthur B, Alok K. Shah, Shah, A.D., McKie, AB, Shah, AD, Michelle M. Hill (144181), Gabra, Hani, Hani Gabra (3096585), Melissa J. Davis (13973), Anup D. Shah (3096588), Michelle M. Hill, Davis, Melissa J, Inder, Kerry L., McKie, A.B., Melissa J. Davis, Hani Gabra, Hill, Michelle M, McKie, Arthur B.   +45 more
core   +1 more source

Bypassing Heteronuclear MRI: Metal‐Free Organosilicon Nanotracers for Background‐Free Hotspot 1H Imaging on Clinical Hardware

Advanced Science, EarlyView.
Organosilicon micelles enable background‐free molecular magnetic resonance imaging (MRI) while remaining fully compatible with standard proton (1H) hardware. By exploiting a spectrally silent 1H window at ∼0 ppm, the silicone nanotracer allows hotspot detection by 1H chemical‐shift imaging (CSI) without metals or heteronuclei, enabling direct overlay ...
Martin Orsagh, Dominik Havlicek, Andrea Galisova, Ondrej Sedlacek, Daniel Jirak   +4 more
wiley   +1 more source

Lipid raft size and lipid mobility in non-raft domains increase during aging and are exacerbated in APP/PS1 mice model of Alzheimer’s disease. Predictions from an agent-based mathematical model

Frontiers in Physiology, 2016
A connection between lipid rafts and Alzheimer’s disease has been studied during the last decades. Mathematical modeling approaches have recently been used to correlate the effects of lipid composition changes in the physicochemical properties of raft ...
Guido eSantos, Mario L Diaz, Nestor V. Torres   +2 more
doaj   +1 more source

Photochemical control of membrane raft organization [PDF]

, 2011
Controllable membrane phase separation through the action of a synthetic photoresponsive amphiphile is reported. We studied multi-component giant vesicles formed from a ternary lipid mixture of saturated and unsaturated phospholipid and cholesterol ...
Takagi, Masahiro, Hamada, Tsutomu, Ryoko Sugimoto, Nagasaki, Takeshi, Tsutomu Hamada, Masahiro Takagi, Sugimoto, Ryoko, Takeshi Nagasaki   +7 more
core   +1 more source

Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants

Advanced Science, EarlyView.
Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer, Rong Zhu, Manuel Reithofer, Gerhard Stadlmayr, Katharina Stadlbauer, Panchika Prangkio, Christoph Rippel, Markus Hahn, Aniko Eva Kasztner, Stefanie Stohl, Petr Bednar, Daniel Ruzek, David Glück, Robert Tampé, Gordana Wozniak‐Knopp, Yoo Jin Oh, Miriam Klausberger, Peter Hinterdorfer   +17 more
wiley   +1 more source