Results 81 to 90 of about 64,062 (299)
Role of lipid rafts and GM1 in the segregation and processing of prion protein.
PLoS ONE, 2014 The prion protein (PrPC) is highly expressed within the nervous system. Similar to other GPI-anchored proteins, PrPC is found in lipid rafts, membrane domains enriched in cholesterol and sphingolipids.
Laura Botto +10 more
doaj +1 more source
Selective Cholesterol Dynamics between Lipoproteins and Caveolae/Lipid Rafts [PDF]
, 2007 Although low-density lipoprotein (LDL) receptor-mediated cholesterol uptake through clathrin-coated pits is now well understood, the molecular details and organizing principles for selective cholesterol uptake/efflux (reverse cholesterol transport, RCT ...
Atshaves, Barbara P. +9 more
core +2 more sources
Lipid Rafts: Membrane Triage Centers [PDF]
Journal of Investigative Dermatology, 2006 Both biochemical and live cell imaging studies suggest the existence of lipid rafts, specialized membrane microdomains that promote interaction among signaling molecules. Although their composition is still poorly understood, these highly dynamic domains are enriched in cholesterol, sphingolipids, and particular groups of proteins.
Wang, Xiao-qi, Paller, Amy S.
openaire +2 more sources
Advanced Science, EarlyView.This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo +9 more
wiley +1 more source
Scientific Reports, 2021 Lipid rafts, sterol-rich and sphingolipid-rich microdomains on the plasma membrane are important in processes like cell signaling, adhesion, and protein and lipid transport.
Shiomi Koudatsu +8 more
doaj +1 more source
Anesthetics interacting with lipid rafts
European Journal of Pharmaceutical Sciences, 2013 The exact mechanism by which anesthetics induce cell membrane-mediated modifications is still an open question. Although the fluidization effect of the anesthetic molecules on the cellular membrane is widely recognized, it is not known if anesthetics show any preference for specific membrane domains, namely the lipid rafts.
Cátia, Bandeiras +4 more
openaire +2 more sources
Cholesterol, lipid rafts, and disease [PDF]
Journal of Clinical Investigation, 2002 Lipid rafts are dynamic assemblies of proteins and lipids that float freely within the liquid-disordered bilayer of cellular membranes but can also cluster to form larger, ordered platforms. Rafts are receiving increasing attention as devices that regulate membrane function in eukaryotic cells.
Simons, K., Ehehalt, R.
openaire +3 more sources
Advanced Science, EarlyView.Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu +11 more
wiley +1 more source
Frontiers in Physiology, 2012 Alterations in the lipid composition of lipid rafts have been demonstrated both in human brain and transgenic mouse models, and it has been postulated that aberrant lipid composition in lipid rafts is partly responsible for neuronal degeneration.
Mario L Diaz +2 more
doaj +1 more source
A sensitive S-Trap-based approach to the analysis of T cell lipid raft proteome
Journal of Lipid Research, 2020 The analysis of T cell lipid raft proteome is challenging due to the highly dynamic nature of rafts and the hydrophobic character of raft-resident proteins.
Cerina Chhuon +8 more
doaj +1 more source