Results 41 to 50 of about 1,513 (210)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

ВЛИЯНИЕ КАЛОРИЙНОСТИ РАЦИОНА НА СОСТОЯНИЕ НЕКОТОРЫХ ЭЛЕМЕНТОВ АНТИОКСИДАНТНОЙ СИСТЕМЫ ЭРИТРОЦИТОВ

Studia Universitatis Moldaviae: Stiinte reale si ale naturii, 2018
EFECTUL CALORICITĂŢII RĂSPUNSULUI PRIVIND STAREA UNOR ELEMENTE ALE SISTEMULUI ANTIOXIDANT DE ERITROCITE  În articol sunt prezentate date privind conținutul formelor oxidate de glutation și carnozină ca componente ale siste-mului antioxidant în ...
USM ADMIN
doaj   +2 more sources

Dislipidemiile în asociere cu alți factori de risc în pancreatita cronică

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2019
Studiul a fost unul prospectiv și a inclus 30 de pacienți cu pancreatită cronică (PC), tratați în secţia de gastroenterologie a SCM ,,Sf. Arh. Mihail”, la care s-a evaluat statusul lipidic în raport cu alți factori de risc.
Rodica Bugai, Cristina Djaman, Ion Ţîbîrnă, Maria Feghiu, Svetlana Chişlaru, Ludmila Panfil   +5 more
doaj  

Arterial age as a substitute for chronological age in the AGLA risk function could improve coronary risk prediction

Swiss Medical Weekly, 2014
PRINCIPLES: As a result of the relatively low sensitivity of coronary risk charts, such as the Swiss coronary risk calculator (Arbeitsgruppe Lipide und Atherosklerose, AGLA), for detecting subjects with future myocardial infarction, the performance of ...
Michel Romanens, Franz Ackermann, Isabella Sudano, Thomas Szucs, J. David Spence   +4 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

INFLUENŢA EXTRACTULUI DE AMINOACIZI ŞI OLIGOPEPTIDE DE ORIGINE CIANOBACTERIANĂ DIN BIOMASA SPIRULINA (ARTHROSPIRA) PLATENSIS ASUPRA CREŞTERII ŞI LIPIDOGENEZEI TULPINII STREPTOMYCES FRADIAE CNMN-Ac-11

Studia Universitatis Moldaviae: Stiinte reale si ale naturii, 2017
A fost studiată capacitatea tulpinii Streptomyces fradiae CNMN-Ac-11, izolată din solurile Părții Centrale a Republicii Moldova, de a acumula biomasă și sinteza lipidelor în dependență de compoziția mediului nutritiv.
USM ADMIN
doaj  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source