Results 71 to 80 of about 1,513 (210)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

IMPACTUL MACRO- ȘI MICRONUTRIENȚILOR ASUPRA STATUTULUI IMUN

open access: yesStudia Universitatis Moldaviae: Stiinte reale si ale naturii
Alimentația este un proces esențial în menținerea sănătății organismului. Macronutrienții (proteinele, glucidele și lipidele) și micronutrienții (vitaminele, mineralele și substanțele biologic active) stau la baza tuturor proceselor organismelor vii ...
USM ADMIN
doaj  

Besinin Plodia interpunctella (Hubner) (Lepidoptera:Pyralidae) Larva ve Pupunun Toplam Lipid, Yağ Asidi Oranlarına ve Yağ Asidi Bileşimine Etkileri

open access: yesSüleyman Demirel Üniversitesi Fen-Edebiyat Fakültesi Fen Dergisi, 2010
Özet: Fındık, yerfıstığı, ceviz, badem ve polen gibi farklı besinlerle beslenen Plodia interpunctella Hübner (Lepidoptera:Pyralidae). larva ve puplarının toplam lipid ve total yağ asidi yüzdeleri ile yağ asidi bileşimi incelendi.
Pelin Üstüner   +2 more
doaj  

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

open access: yesMolecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Insulin resistance mediates obesity-related risk of cardiovascular disease: a prospective cohort study. [PDF]

open access: yesCardiovasc Diabetol, 2022
Tian X   +7 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

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