Results 131 to 140 of about 34,809 (298)

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

open access: yesExploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi   +5 more
wiley   +1 more source

Randomization versus population models employed in lipidomic data analysis

open access: yes
Herein we present the analysis and comparing fundamental chemometric methods: fold change (FC) analysis and univariate statistics for identifying differentially expressed lipids in human serum samples into pancreatic cancer or control group, using a ...
Masnikosa, Romana   +2 more
core   +1 more source

Advances in Anthocyanin Recovery and Purification From Natural Sources: Bioavailability, Mechanistic Action in the Human Body and Applications in Novel Food Development

open access: yesFood Chemistry International, EarlyView.
This review highlights green recovery, purification, stabilisation, bioavailability, health relevance, and novel food applications of anthocyanins from natural and agro‐industrial sources. ABSTRACT Anthocyanins are water‐soluble natural pigments and multifunctional food ingredients that support clean‐label colour, antioxidant activity, and value‐added ...
Chandan Kumar Sahu   +4 more
wiley   +1 more source

Bioactive compounds in insects—Composition, extraction, functionality, food applications, and safety concerns

open access: yesFood Biomacromolecules, EarlyView.
This review synthesizes 94 studies (2000–2025) exploring edible insects as sustainable sources of peptides, lipids, and chitin. Utilizing “green” extraction, these bioactives offer antioxidant and antimicrobial benefits for functional foods. However, addressing safety concerns like allergenicity and heavy metals through standardized frameworks remains ...
Blessing Rachael Adeyeye   +1 more
wiley   +1 more source

Gestational Age and the Cord Blood Lipidomic Profile in Late Preterm and Term Infants

open access: yes, 2018
Background: Lipid metabolism is vital to fetal development and cardiometabolic health and the final weeks of gestation are known to be a time of intense metabolic activity.
J Blangero (10572341)   +12 more
core  

Plasma Lipidomic Patterns in Patients with Symptomatic Coronary Microvascular Dysfunction.

open access: yes, 2021
Coronary microvascular dysfunction (MVD) is a syndrome of abnormal regulation of vascular tone, particularly during increased metabolic demand. While there are several risk factors for MVD, some of which are similar to those for coronary artery disease ...
Layoun, Michael   +16 more
core  

Seed lipid profiles of perennial ryegrass: Global patterns and differentiation of ryegrass cultivars and Epichloë endophytes

open access: yesGrassland Research, EarlyView.
Seed lipid profiles from three ryegrass cultivars infected with AR501 show distinct changes in the medium‐chain diacylglycerols, triacylglycerols and sphingolipids. The differential peal LN745.5052_5.78 can be identified as PG 16:0_18:2 with the supporting ms2 fragmentation spectrum. Abstract Background Forage perennial ryegrass (Lolium perenne L.) has
Mingshu Cao   +6 more
wiley   +1 more source

Lipidomic and sterolomic profiles of different brain regions in the mouse model of Alzheimer’s disease

open access: yesNeural Regeneration Research
Alzheimer’s disease is the most common cause of dementia. Although increasing evidence suggests that disruptions in lipid metabolism are closely associated with the disease, the overall profile of lipid and sterol changes that occur in the brain during ...
Xingsen Zhao   +6 more
doaj   +1 more source

Lipidomic profiles reveal the membrane lipid phase transition pattern in chilling-shocked cotton seedlings

open access: yesIndustrial Crops and Products
Cotton (Gossypium spp), originating from tropical and subtropical regions, is an important natural fiber crop and is currently cultivated across a wide range of latitudes.
Li Yu   +11 more
doaj   +1 more source

Redefining Fatty Liver Disease: How Updated Nomenclature Reshapes Clinical Laboratory Diagnostics

open access: yesiLABMED, EarlyView.
The transition from nonalcoholic fatty liver disease (NAFLD) to metabolic dysfunction‐associated steatotic liver disease (MASLD) reorients laboratory diagnosis from exclusion‐based rules toward metabolic and inflammatory biomarkers. This review compares their diagnostic criteria, epidemiology, insulin resistance mechanisms, imaging, and key laboratory ...
Ran Wei   +3 more
wiley   +1 more source

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