Results 121 to 130 of about 949 (209)

Seven days of mixed‐method heat acclimation improved markers of cardiovascular and fluid‐regulatory strain during exercise‐heat stress

open access: yesExperimental Physiology, EarlyView.
Abstract A mixed‐method heat acclimation (HA) protocol may optimise performance by supporting the training taper while promoting thermal adaptation; however, the impact on cardiovascular and fluid‐regulatory adjustments to protect health is unknown. Therefore, we examined the effects of a mixed‐method heat protocol on physiological responses, including
Daniel Snape   +5 more
wiley   +1 more source

One day of environment‐induced heat stress causes injury to the murine kidney

open access: yesExperimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths   +3 more
wiley   +1 more source

Effect of foot immersion and neck cooling on renal, intestinal, immune and inflammatory markers in older adults exposed to extreme heat

open access: yesExperimental Physiology, EarlyView.
Abstract Older adults with reduced thermoregulatory capabilities are increasingly at risk of heat‐related pathophysiological outcomes (e.g., acute kidney injury, heatstroke) due to increasingly frequent, prolonged and intense heatwaves. Foot immersion and neck cooling have been proposed as practical, non‐electrical cooling strategies for protecting ...
Thomas McCarthy   +7 more
wiley   +1 more source

Distantly related lipocalins share two conserved clusters of hydrophobic residues: use in homology modeling-1

open access: yes, 2011
Copyright information:Taken from "Distantly related lipocalins share two conserved clusters of hydrophobic residues: use in homology modeling"http://www.biomedcentral.com/1472-6807/8/1BMC Structural Biology 2008;8():1-1.Published online 11 Jan 2008PMCID ...
Benoit Charloteaux (87758)   +6 more
core   +1 more source

Pets, furry animal allergen components, and asthma in childhood

open access: yesClinical and Translational Allergy
Background The use of component‐resolved allergy diagnostics has provided a clearer understanding of the species‐specific sensitization and severity of potential allergic reactions.
Katariina Lajunen   +8 more
doaj   +1 more source

Dual roles of tear lipocalins as ‘chemical signalling’ and ‘toxic waste disposal’ systems of the house mouse

open access: yes, 2017
Mammalian tears are produced by lacrimal glands to protect eyes and to function in chemical communication and immunity. However, excess tears flow through nasolacrimal ductsto nasal tissues, and via the nasopharyngeal duct to the oral cavity where ...
Romana Stopkova   +3 more
core   +1 more source

Tripterine Liposome Exerts Antitumor and Immunomodulatory Effects in Pancreatic Ductal Adenocarcinoma

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Tripterine liposome (TP‐lipo) exerts anti‐pancreatic ductal adenocarcinoma (PDAC) effects through direct suppression of tumor cells and modulation of the tumor microenvironment (TME). TP‐lipo induces apoptosis and inhibits the clonogenicity, migration, and invasion of KPC cells in vitro.
Lirui Tang   +8 more
wiley   +1 more source

Mesenchymal Stem Cell‐Derived Extracellular Vesicles Ameliorate NaIO3‐Induced Dry AMD by Delivering miR‐486‐3p to Inhibit Lipocalin‐2‐Mediated Ferroptosis

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Our study reveals a novel mechanism by which MSC‐derived EVs alleviate NaIO3‐induced dry AMD‐like pathology. MSC‐EVs deliver miR‐486‐3p into retinal cells to directly inhibit the ferroptosis‐promoting target gene Lcn2. Concurrently, downregulated Lcn2 restores intracellular Gpx4 expression, thereby suppressing ferroptosis and rescuing retinal ...
Zheng Li   +6 more
wiley   +1 more source

Data_Sheet_1_Human lipocalins bind and export fatty acids through the secretory pathway of yeast cells.PDF

open access: yes
The activation of fatty acids to their acyl-CoA derivatives is a crucial step for their integration into more complex lipids or their degradation via beta-oxidation.
Aslihan Ekim Kocabey (17739546)   +1 more
core   +1 more source

Transcriptomic and proteomic signatures underlying nymphal adaptation and foam production in the forage pest Mahanarva spectabilis

open access: yesInsect Molecular Biology, Volume 35, Issue 5, Page 556-575, October 2026.
RNA‐seq and Batelli gland proteomics of fifth‐instar Mahanarva spectabilis nymphs reveal transcripts and proteins associated with xylem feeding, foam production and environmental interaction. Functional annotation identified genes involved in osmoregulation, detoxification, chemosensation and stress responses, while proteomic analysis confirmed ...
Monique da Silva Bonjour   +8 more
wiley   +1 more source

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