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Equine neuronal ceroid lipofuscinosis
Acta Neuropathologica, 2001Neuronal ceroid lipofuscinosis (NCL) is an inherited, neurodegenerative disorder with fatal outcome in humans. It has also been described in some animal species; this is the first report of NCL in equines. Three horses showed developmental retardation, slow movements and loss of appetite at the age of six months.
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Canine ceroid-lipofuscinosis — A model for human neuronal ceroid-lipofuscinosis and aging
Mechanisms of Ageing and Development, 1973Abstract A controlled longitudinal morphologic study revealed that the formation and accumulation of an autofluorescent lipopigment, identified as “ceroid” in the isolated state, commences in utero and progresses linearly with time. Only after a distinct loss of neurocytoplasm and its functional organelles is demonstrable, do clinical signs and ...
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MRI in neuronal ceroid lipofuscinosis
Neurological Sciences, 2000Magnetic resonance imaging in neuronal ceroid lipofuscinosis (NCL) demonstrates cerebral and cerebellar atrophy, T2-hyperintensity of the lobar white matter and thinning of the cerebral cortex. The association of these findings, although non specific, can be observed in all the different forms of NCL, narrows the differential diagnosis of the infantile
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Localised Histiocytic Lipofuscinosis
The American Journal of Dermatopathology, 1993We report a case in an 86-year-old woman, of a localised aggregate of lipofuscin-laden histiocytes presenting as a pigmented lesion with local itching. Histologically, there was a diffuse dermal infiltrate of mononuclear cells, predominantly histiocytes containing golden-brown pigment shown to be lipofuscin.
E E, Mooney, E, Sweeney
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[Lipofuscinosis of the liver].
Ceskoslovenska patologie, 1980Liver tissue biopsy performed in a man of 44 and another man of 52, who had for long periods of time been using phenacetin-containing analgesics, revealed accumulations of lipofuscin in hepatocytes, in sinoendothelia and in Kupffer's cells. Apart from more frequent destruction of hepatocytes, there were no microscopic or ultrastructural changes ...
A, Chlumská, V, Czabanová
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Neuronal ceroid-lipofuscinosis and metachromasia
Acta Neuropathologica, 1980Two cases of neuronal ceroid-lipofuscinosis are described. They presented in the white matter granular material which stained metachromatically with toluidine blue in paraffin sections. The origin of this material is discussed.
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Adult Type of Neuronal Ceroid Lipofuscinosis
Developmental Neuroscience, 1991Adult neuronal ceroid lipofuscinosis (NCL), also called Kufs'' disease, is clinically distinct from the other NCLs. It is a rare condition which is difficult to diagnose. More than 50% of the reported cases of Kufs'' disease are not adult NCL and correspond very likely to a heterogeneous spectrum of lipidoses. Various clinical and genetic phenotypes of
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Neuronal Ceroid-Lipofuscinosis
Archives of Neurology, 1977To the Editor.— We read with interest the article by Markesbery et al in the September issue of theArchives. We believe these authors' studies confirm our initial reports of the contribution to the diagnosis of the neuronal ceroid-lipofuscinosis by electron microscopical study of lymphocytes in patients with clinical manifestation of the disease.
P. M. MacLeod, C. L. Dolman
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Tijdschrift voor kindergeneeskunde, 1989
Experiences with the care for the 37 patients with the juvenile type of neuronal (generalised) ceroid lipofuscinoses in a centre for multihandicapped people are described. Besides abnormalities of the visual and the nervous system attention is given to the psychopathological and cardiovascular symptoms.
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Experiences with the care for the 37 patients with the juvenile type of neuronal (generalised) ceroid lipofuscinoses in a centre for multihandicapped people are described. Besides abnormalities of the visual and the nervous system attention is given to the psychopathological and cardiovascular symptoms.
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