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Cyclopeptamine lipopeptide antifungal agents
Expert Opinion on Therapeutic Patents, 1999A solid phase mediated automated process was developed and used by researchers at Abbott laboratories to synthesise structurally diverse amino-lipopeptides as antifungal compounds. The cyclopeptamine analogues produced by this method possess an amino or substituted amino functionality in the proline ring (A) (Figure 2).
Debashis Ganguly, Michael J Rodriguez
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Synthesis of Lipopeptides by CLipPA Chemistry
2021Lipidation of polypeptides with a fatty acid to form N-linked lipopeptides can be a time consuming process due to the need to mask other reactive function groups present on the side chains of amino acids. Cysteine Lipidation on a Peptide or Amino acid (CLipPA) technology enables the direct lipidation of unprotected peptides containing a free thiol ...
Victor, Yim +3 more
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Structure elucidation of bacterial nonribosomal lipopeptides
Organic & Biomolecular Chemistry, 2020We provide a summary of the tools, which allow elucidate the structures of nonribosomal lipopetides.
Sebastian Götze, Pierre Stallforth
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Structure–Activity Relationships of Daptomycin Lipopeptides
Journal of Medicinal Chemistry, 2020Daptomycin is a calcium-dependent cyclic lipodepsipeptide derived from the soil saprotroph Streptomyces roseosporus, and its antibiotic properties make it a key agent for treatment of drug-resistant Gram-positive infections. It is most commonly used clinically for the treatment of Gram-positive skin and skin structure infections (SSSI), Staphylococcus ...
John A. Karas +8 more
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Lipopeptides as tools in catalysis, supramolecular, materials and medicinal chemistry
Nature Reviews Chemistry, 2023César Vicente-García, Ignacio Colomer
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Novel dendrimeric lipopeptides with antifungal activity
Bioorganic & Medicinal Chemistry Letters, 2012A series of new cationic lipopeptides containing branched, amphiphilic polar head derived from (Lys)Lys(Lys) dendron and C(8) or C(12) chain at C-end were designed, synthesized and characterized. Antimicrobial in vitro activity expressed as minimal inhibitory concentration (MIC) was evaluated against Gram-positive and Gram-negative bacteria and yeasts ...
Jolanta, Janiszewska +6 more
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The Cyclic Lipopeptide Antibiotics
2017The cyclic lipopeptides comprise a number of clinically relevant classes of antibiotics that date back from the discovery of the polymyxins in 1947 to the recent introduction of the semi-synthetic lipoglycopeptides. These natural products and natural product derivatives most often originate from soil-inhabiting and/or plant-derived producing organisms.
Laurens H. J. Kleijn +1 more
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Biophysical studies of lipopeptide‐membrane interactions
Biopolymers, 1997There are a number of naturally occurring motifs for lipidation of peptides and proteins. In cases in which this involves adding a single hydrocarbon chain to the peptide, it is either a fatty acid or an isoprenyl group. Lipopeptides will partition between membrane and aqueous phases.
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Nematicidal lipopeptides from Bacillus paralicheniformis and Bacillus subtilis: A comparative study
Applied Microbiology and Biotechnology, 2023Estefany Chavarria-Quicaño +4 more
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