Cu7S4 nanozymes, exhibiting peroxidase‐like, catalase‐like, and GSH‐depletion activities, are synthesized through defect engineering. These nanozymes demonstrate rapid inactivation of Gram‐negative bacteria, including Escherichia coli and Pseudomonas aeruginosa. In a mouse skin wound model infected with P. aeruginosa, the nanozyme showcases exceptional
Xueya Li+15 more
wiley +1 more source
Yuanhuacine modulates lipopolysaccharide-induced interleukin-6 through regulation of the JAK1/STAT3 pathway and prevents tubular damage in acute kidney injury. [PDF]
Park UJ, Kim JW.
europepmc +1 more source
γGC deficiency in ulcerative colitis drives macrophage ferroptosis‐mediated inflammation. Claw‐engaged microparticles armed with γGC (γGC‐MPs) enhance lesion targeting, promoting localized γGC release and tissue uptake. On the cover, Monkey King (Macrophages) was bound by the Immortal‐Binding Rope and subsequently sealed beneath the Five‐Fingered ...
Rong Wang+10 more
wiley +1 more source
Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formation. [PDF]
Nosaka N+5 more
europepmc +1 more source
Regulation of Neuroinflammation by Microglial DUBA‐IRAK1‐IKKβ Signaling Loop
The protein levels of deubiquitinating enzyme A (DUBA) are rapidly upregulated in microglia after activation of Toll‐like receptor 4 (TLR4). In turn, DUBA potentiates TLR4‐induced proinflammatory signal transduction in microglia by stabilizing interleukin‐1 receptor activated kinase 1 (IRAK1) through K48 deubiquitination.
Zhenhu Zhu+22 more
wiley +1 more source
Nutrient-Synbiotic Complex Ameliorates LPS-Induced Depressive-Like Behavior via Modulation of Gut Microbiota and Tryptophan Metabolism in Mice. [PDF]
Liu Z+7 more
europepmc +1 more source
A Novel nor@DHB Matrix for Direct Microbial Analysis in Lung Cancer Tissues
Integrated matrix‐assisted laser desorption/ionization mass spectrometry workflow quantifies intratumoral microbes in lung cancer through lipopolysaccharide/lipid A extraction from biopsies. The novel ionic matrix called norharmane conjugated to 2,5‐dihydroxybenzoic acid enhances lipid A ionization, enabling direct detection of bacterial genera ...
Liang Shan+12 more
wiley +1 more source
A Systems Hypothesis of Lipopolysaccharide-Induced Vitamin Transport Suppression and Metabolic Reprogramming in Autism Spectrum Disorders: An Open Call for Validation and Therapeutic Translation. [PDF]
Dervishi A.
europepmc +1 more source