Results 291 to 300 of about 640,235 (385)

Omics-based integrative analysis of sepsis-induced myocardial dysfunction. [PDF]

J Int Med Res
Zhao JW, Dong ZX, Wang W, Sheng SQ, Yu KJ.   +4 more
europepmc   +1 more source

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

Proceedings of the National Academy of Sciences of the United States of America, 2015
C. Sandiego, J. Gallezot, B. Pittman, N. Nabulsi, Keunpoong Lim, Shu-Fei Lin, D. Matuskey, Jae-Yun Lee, K. O’Connor, Yiyun Huang, R. Carson, J. Hannestad, K. Cosgrove   +12 more
semanticscholar   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Lactobacilli-based postbiotic differentially affects chicken macrophage-like HD11 cells depending on stimulatory lipopolysaccharide dosage. [PDF]

BMC Vet Res
Jansseune SCG, van Baal J, Blanc F, Lammers A.   +3 more
europepmc   +1 more source

Redox Cascade in Chicken Skeletal Muscle: SELENOT Suppression in Selenium Deficiency Triggers Disulfidptosis via mtROS‐NADPH Dysregulation

Advanced Science, EarlyView.
Se deficiency downregulates SELENOT, disrupting mitochondrial function and elevating mtROS to induce glucose metabolic reprogramming, NADPH depletion, cysteine accumulation, and disulfidptosis‐mediated actin cytoskeleton collapse in chicken skeletal muscle.
Huanyi Liu, Hao Wu, Ziyu Zhang, Shiwen Xu, Cong Zhou, Tong Xu   +5 more
wiley   +1 more source

Succinic Acid‐Induced Macrophage Endocytosis Promotes Extracellular Vesicle‐Based Integrin Beta1 Transfer Accelerating Fibroblast Activation and Sepsis‐Associated Pulmonary Fibrosis

Advanced Science, EarlyView.
Lipopolysaccharide (LPS) stimulates the production of succinic acid in lung tissue, which promotes macrophages endocytosis and the formation of multivesicular bodies (MVBs). These MVBs release profibrotic extracellular vesicles (EVs), facilitating the transfer of integrin beta1 (ITGβ1) transfer and subsequently activating fibroblasts, thereby ...
Wenyu Yang, Ri Tang, Yang Zhou, Jinquan Zhang, Shuya Mei, Yawen Peng, Xi Huang, Shunpeng Xing, Yuan Gao, Qiaoyi Xu, Zhengyu He   +10 more
wiley   +1 more source

The fatty acid synthesis gene <i>fabY</i> affects lipopolysaccharide synthesis and colistin susceptibility in <i>Pseudomonas aeruginosa</i>. [PDF]

Microbiol Spectr
Zhou D, Wei X, Jin Y, Cheng Z, Jin S, Ha U-H, Pan X, Wu W.   +7 more
europepmc   +1 more source

Systemic inflammatory response and serum lipopolysaccharide levels predict multiple organ failure and death in alcoholic hepatitis

Hepatology, 2015
J. Michelena, J. Altamirano, J. Abraldes, Silvia Affò, O. Morales‐Ibanez, P. Sancho-Bru, M. Domínguez, J. García‐Pagán, Javier Fernández, V. Arroyo, P. Ginés, A. Louvet, P. Mathurin, W. Mehal, J. Caballería, R. Bataller   +15 more
semanticscholar   +1 more source

Single‐Cell Dissection of the Biological Function and Molecular Features Underlying the Micropeptide LSMEM1 in Kidney

Advanced Science, EarlyView.
LSMEM1, an evolutionarily conserved micropeptide with extreme hydrophobicity (aliphatic index═113) and dynamic amphiphilicity (GRAVY═0.017), features a strong α‐helical transmembrane anchor (residues 64‐86). Single‐cell analysis reveals its critical role in renal lipid homeostasis.
Peimin Liu, Hong Zhang, Shanzhi Yang, Jiaoqing Li, Danfeng Wu, Haosen Xu, Huan Jiang, Yi Jing, Guoxiang Jin, Ruobing Liu, Ning Fan, Xiaoyan Bai   +11 more
wiley   +1 more source

Fuzheng Xuanfei Huashi prescription suppresses inflammation in lipopolysaccharide-induced lung injury in mice toll-like recptor 4/nuclear transcription factor κB and cyclooxygenase-2/prostaglandin E2 pathway. [PDF]

J Tradit Chin Med
Haiyang H, Shumin Z, Shaowen Z, Ying L, Shaozhen H, Jie G, Jianzhao OU, Mingguo D, Weimin N.   +8 more
europepmc   +1 more source