Results 181 to 190 of about 164,679 (343)

Mesencephalic Astrocyte‐Derived Neurotrophic Factor Binds BAX to Preserve Mitochondrial Homeostasis and Energy Metabolism for Relieving Myocardial Hypertrophy

open access: yesAdvanced Science, EarlyView.
MANF in cardiomyocytes interacts with BAX to impede BAX mitochondrial translocation and cytochrome c release, further stabilizing mitochondrial structure and energy supply to relieve myocardial apoptosis and hypertrophy, which indicates MANF as a novel cardioprotective factor to have a promising clinical application for myocardial hypertrophy ...
Dong Wang   +13 more
wiley   +1 more source

Lipopolysaccharides of Salmonella T Mutants [PDF]

open access: bronze, 1967
Robert W. Wheat   +4 more
openalex   +1 more source

CellPhenoX: An Explainable Machine Learning Method for Identifying Cell Phenotypes To Predict Clinical Outcomes from Single‐Cell Multi‐Omics

open access: yesAdvanced Science, EarlyView.
CellPhenoX is an explainable machine learning framework that identifies cell‐specific phenotypes and interaction effects from single‐cell omics data. By leveraging interpretable models, it enables robust discovery of cell‐level phenotypes that contribute to clinical outcomes.
Jade Young   +4 more
wiley   +1 more source

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

open access: yesAdvanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao   +9 more
wiley   +1 more source

Investigation of the effects of lipopolysaccharide preconditioning on neuropathic pain induced by chronic sciatic nerve constriction injury in rats [PDF]

open access: yesJournal of Clinical and Basic Research
Background: Neuropathic pain results from nerve injury and involves pro-inflammatory cytokines that activate pain-sensing neurons, contributing to both the onset and maintenance of pain.
Soqra Hesam   +3 more
doaj  

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