Results 271 to 280 of about 164,679 (343)

Effect of lipopolysaccharides and mixed Eimeria spp. challenge on performance and bone development in broilers. [PDF]

Poult Sci
Choppa VSR, Liu G, Shi H, Sharma MK, Goo D, Kim WK.   +5 more
europepmc   +1 more source

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source

Erythrocyte membrane coated biodegradable nanoparticles detoxify LPS-induced toxicity by producing non-mutagenic metabolites and downregulating pro-inflammatory cytokines and oxidative stress markers. [PDF]

Sci Rep
Aslam T, Akhtar B, Sharif A, Anjum F, Ali S, Fatima SA, Mehmood T.   +6 more
europepmc   +1 more source

Clinically Inspired Multimodal Treatment Using Induced Neural Stem Cells‐Derived Exosomes Promotes Recovery of Traumatic Brain Injury through Microglial Modulation

Advanced Science, EarlyView.
This study explores the therapeutic potential of iNSC‐Exo via local and systemic delivery in TBI mice. It is found that iNSC‐Exo enhances NRXN signaling through Microglia_Nrg3 and Microglia_Rarb, effectively promoting functional and neurological recovery, suggesting a new therapeutic strategy for TBI. Abstract Traumatic brain injury (TBI) poses serious
Jiaojiao Li, Maoxiang Xu, Boyu Cai, Xiangyu Li, Zhanping Liang, Xiaohuan Xia, Haitao Zhang, Zhiwen Zhang, Fei Tan, Jialin Charlie Zheng   +9 more
wiley   +1 more source

<i>Akkermansia muciniphila</i>-derived hypoacylated rough-type lipopolysaccharides alleviate diet-induced obesity via activation of TLR4-IL-23-IL-22 immune axis. [PDF]

Imeta
Sun L, Zhang Y, Dong W, Sun J, Wang T, Shao F, Dai H, Han J, Wang W, Wang S, Zhao T, Wang L, Liu C, Liu S, Liu H.   +14 more
europepmc   +1 more source

Clathrin Light Chain B Drives Hepatocellular Carcinoma Progression Through Dual Mechanisms: Small Extracellular Vesicle‐Mediated Angiogenesis and the NF‐κB–PCLAF Signaling Axis

Advanced Science, EarlyView.
Clathrin Light Chain B (CLTB) drives hepatocellular carcinoma progression through dual pathways: intracellularly, it activates the NF‐κB–PCLAF axis to enhance small extracellular vesicle (sEV) uptake and tumor proliferation; extracellularly, CLTB‐enriched sEVs bind SH3KBP1 to inhibit its degradation, inducing angiogenesis and vascular leakage ...
Xiaoke Sun, Junchen Guo, Ning Zhao, Guanghua Cui, Yun Bai, Meijuan Ding, Yi Xu, Yu Yang   +7 more
wiley   +1 more source

Ngf/TrKA signal is associated with macrophage activation of acute kidney injury in mice. [PDF]

Ren Fail
Tang Q, Liu K, Tang Y, Xiao Q, Huang L, Li G, Wang L, Li Y.   +7 more
europepmc   +1 more source

Metabolic Interplay in Acute Lung Injury: PARK7 Integrates FADS1/2‐Dependent PUFA Metabolism and H3K14 Lactylation to Attenuate Endothelial Ferroptosis and Dysfunction

Advanced Science, EarlyView.
SCAP/ARDS patients show reduced unsaturated fatty acids (UFAs) but higher PARK7 and lactate in plasma. PARK7 correlates positively with lactate and negatively with UFAs. Pulmonary endothelial cell multi‐omics show FADS1/2 downregulation and impaired PUFA metabolism. Lactate boosts PARK7 via H3K14 lactylation, and PARK7 then restores FADS1/2.
Jian Xu, Yuhan Wang, Weiqi Mao, Tianchang Wei, Yufan Li, Juan Song, Cuiping Zhang, Xiaoyan Chen, Cuicui Chen, Qingyuan Xu, Xu Wu, Yuanlin Song   +11 more
wiley   +1 more source

Activation of the Classical and Properdin Pathways of Complement by Bacterial Lipopolysaccharides (LPS)

, 1977
David C. Morrison, Lois Kline
openalex   +1 more source

Utilizing Proteolytic‐Resistant Nano‐Short Peptide Based on Naphthyl Tail‐Anchored to Combat Bacterial Infections

Advanced Science, EarlyView.
Antimicrobial peptides (AMPs) show potential as alternatives to antibiotics for bacterial infections; however, their susceptibility to proteases limits wider application. In this study, N4 nanofibers are constructed by integrating anti‐enzymolysis motif into the self‐assembly system triggered by naphthyl‐anchored.
Xi Yan, Yinfeng Lyu, Yi Liu, Jianping Ren, Yue Zhao, Licong Zhang, Anshan Shan   +6 more
wiley   +1 more source