Results 231 to 240 of about 585,044 (300)

Causal associations between human metabolites and functional dyspepsia: Evidence from two sample and multivariable Mendelian randomization. [PDF]

Medicine (Baltimore)
Long L, Li M, Liu L, Zhang L.
europepmc   +1 more source

Biography as the Missing Variable in Drug Development: A Case for Bio‐Biographical Mechanistic Profiling

Clinical Pharmacology &Therapeutics, EarlyView.
Most clinical trial failures reflect unmeasured biological heterogeneity. Biography — chronic stress, adversity, trauma, and social isolation—is a neglected source of that heterogeneity, operating through the same molecular pathways drugs engage.
Ralph I. Horwitz
wiley   +1 more source

Lipoprotein(a) in Personalized Cardiovascular Prevention: Risk Stratification, Coronary Artery Calcium, and Emerging Lp(a)-Lowering Therapies. [PDF]

J Clin Med
Syed AB, Michalak S, Potulapati IKR, Vignarajah A, Shah GV.   +4 more
europepmc   +1 more source

Triglyceride Polygenic Score Identifies Individuals Who May Respond Differently to Aspirin in Primary Prevention

Clinical Pharmacology &Therapeutics, EarlyView.
Low‐dose aspirin is no longer routinely recommended for the primary prevention of cardiovascular disease in older adults due to a lack of net benefit over bleeding risk. We hypothesized that genetic subgroups may experience differential harm or benefit from aspirin therapy.
Peter D. Fransquet, Chenglong Yu, Cammie Tran, Sultana Monira Hussain, Chad A. Bousman, Mark R. Nelson, Andrew M. Tonkin, John J. McNeil, Paul Lacaze   +8 more
wiley   +1 more source

Neutrophil-to-HDL cholesterol ratio and cardiovascular disease coexistence in COPD patients: An NHANES 2007 to 2018 analysis. [PDF]

Medicine (Baltimore)
Zhang X, Duan J.
europepmc   +1 more source

Impact of Drone Versus Car Transport on Anti‐Doping Sample Integrity Over Short Distances: A Proof‐Of‐Concept Study

Drug Testing and Analysis, EarlyView.
This proof‐of‐concept study evaluated the impact of short‐distance drone transport on anti‐doping sample integrity compared with traditional car transport. Targeted assays and untargeted metabolomics revealed equivalent biological profiles between methods, confirming that drone delivery preserves sample integrity for the athlete biological passport ...
I. Al‐Mohannadi, M. Y. Al‐Jaber, M. Al‐Nesf, W. Samsam, Abdulaziz Farooq, N. M. Thomas, M. Stuart, N. Robinson, G. Zangenfeind, D. Rovira, N. Mohamed‐Ali, A. Beotra, V. Mohamed‐Ali, M. Al‐Maadheed   +13 more
wiley   +1 more source

Non-HDL-C to HDL-C ratio and risks of all-cause and cardiovascular mortality in patients with coronary heart disease and type 2 diabetes mellitus: Results from NHANES 2005 to 2018. [PDF]

Medicine (Baltimore)
Wang N, Chen X, Li H, Cheng S, Hu Y, Wang L, Zhou Q, Zhang Q, Hao J, Qi C.   +9 more
europepmc   +1 more source

A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble, Samantha L. Payne, Matthew K. Vickaryous   +2 more
wiley   +1 more source

Causal determinants of gout in 614,000 adults: A two-sample Mendelian randomization study of dietary, lifestyle, and metabolic traits. [PDF]

Medicine (Baltimore)
Jareebi MA.
europepmc   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source