Results 51 to 60 of about 769,860 (308)

Biological, clinical and population relevance of 95 loci for blood lipids. [PDF]

, 2010
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic ...
Aulchenko, Yurii S, Barbalic, Maja, Bis, Joshua C, Chambers, John, Chasman, Daniel I, Croteau-Chonka, Damien C, Edmondson, Andrew C, Feitosa, Mary F, Fouchier, Sigrid W, Guo, Xiuqing, Hua Zhao, Jing, Isaacs, Aaron, Jin Go, Min, Jin Kim, Young, Johansen, Christopher T, Johnson, Toby, Kim, Kyunga, Koseki, Masahiro, Lamina, Claudia, Lange, Leslie A, Lee, Jong-Young, Li, Mingyao, Li, Xiaohui, Luan, Jian'an, McCarthy, Mark I, McPherson, Ruth, Meitinger, Thomas, Melander, Olle, Montgomery, Grant W, Musunuru, Kiran, Nickerson, Deborah A, Nieminen, Markku S, O'Donnell, Christopher J, Oostra, Ben A, Orho-Melander, Marju, Pare, Guillaume, Park, Taesung, Parker, Alex N, Pattaro, Cristian, Pedersen, Nancy L, Peloso, Gina M, Penninx, Brenda WJH, Perola, Markus, Pichler, Irene, Pirruccello, James P, Pramstaller, Peter P, Psaty, Bruce M, Ricketts, Sally L, Rieder, Mark, Ripatti, Samuli, Roberts, Robert, Rose, Lynda M, Rudan, Igor, Ruokonen, Aimo, Sabatti, Chiara, Saharinen, Juha, Salomaa, Veikko, Sanna, Serena, Schlessinger, David, Scott, James, Scuteri, Angelo, Shin Cho, Yoon, Sijbrands, Eric JG, Silander, Kaisa, Sim, Xueling, Sinisalo, Juha, Smit, Johannes H, Smith, Albert V, Smith, Joshua D, Song, Kijoung, Soranzo, Nicole, Spector, Tim D, Stringham, Heather M, Stylianou, Ioannis M, Surakka, Ida, Tanaka, Toshiko, Teslovich, Tanya M, Thompson, John R, Thorleifsson, Gudmar, Tuomilehto, Jaakko, Twee-Hee Ong, Rick, Uda, Manuela, Uitterlinden, Andre G, Vitart, Veronique, Voight, Benjamin F, Vollenweider, Peter, Waeber, Gérard, Wareham, Nicholas J, Waterworth, Dawn M, Whitfield, John B, Wichmann, H-Erich, Willemsen, Gonneke, Willer, Cristen J, Wilson, James F, Witteman, Jacqueline CM, Wright, Alan F, Yuan, Xin, Zee, Robert YL, Zhang, Weihua, Ziegler, Andreas   +99 more
core  

The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain. [PDF]

, 2016
GPIHBP1 is a glycolipid-anchored membrane protein of capillary endothelial cells that binds lipoprotein lipase (LPL) within the interstitial space and shuttles it to the capillary lumen.
Beigneux, Anne P, Bensadouen, André, Fong, Loren G, Gårdsvoll, Henrik, Jørgensen, Thomas Jd, Kristensen, Kristian Kølby, Larsson, Mikael, Mysling, Simon, Ploug, Michael, Young, Stephen G   +9 more
core   +4 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Protein polymorphism of a human plasma apolipoprotein D antigenic epitope.

Journal of Lipid Research, 1989
Based on our previous observation that monoclonal antibody anti-apoD-4E11 reacted with several HDL proteins we studied them further with three questions in mind: i) is there common protein polymorphism in healthy individuals?
R Camato, Y L Marcel, R W Milne, S Lussier-Cacan, P K Weech   +4 more
doaj   +1 more source

Lipoprotein particles in patients with pediatric Cushing disease and possible cardiovascular risks. [PDF]

, 2019
BackgroundCardiovascular (CV) complications are the most significant cause of mortality in adults with Cushing disease (CD); little is known about CV risk factors in children with CD.
Belyavskaya, Elena, Cheung, Anita, De La Luz Sierra, Maria, Keil, Meg, Lodish, Maya, Lyssikatos, Charalampos, Makri, Angeliki, Remaley, Alan T, Sampson, Maureen, Sinaii, Ninet, Stratakis, Constantine A   +10 more
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Apolipoprotein A-I assayed in human serum by isotope dilution as a potential standard for immunoassay.

Journal of Lipid Research, 1988
We measured the amount of apoA-I in serum by isotope dilution, finding 1.33 mg/ml (standard deviation 0.177) in six normolipidemic, healthy subjects. We developed this method by adapting published techniques to purify apoA-I from 3 ml of serum in two ...
P K Weech, D Jewer, Y L Marcel
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Cu2(+)-mediated oxidation of dialyzed plasma: effects on low and high density lipoproteins and cholesteryl ester transfer protein.

Journal of Lipid Research, 1991
We previously reported that the expression of an epitope of apolipoprotein B (apoB), mapped to the C-terminus and defined by antibody Bsol7, increased during Cu2(+)-mediated oxidation of isolated low density lipoprotein (LDL).
Z Zawadzki, RW Milne, YL Marcel
doaj   +1 more source

Oral Apolipoprotein A-I Mimetic D-4F Lowers HDL-Inflammatory Index in High-Risk Patients: A First-in-Human Multiple-Dose, Randomized Controlled Trial. [PDF]

, 2017
A single dose of the apolipoprotein (apo)A-I mimetic peptide D-4F rendered high-density lipoprotein (HDL) less inflammatory, motivating the first multiple-dose study. We aimed to assess safety/tolerability, pharmacokinetics, and pharmacodynamics of daily,
Bloedon, LeAnne T., Duffy, Danielle, Dunbar, Richard L., Fogelman, Alan M., Movva, Rajesh, Navab, Mohamad, Norris, Robert B., Rader, Daniel J.   +7 more
core   +2 more sources