Results 201 to 210 of about 801,768 (340)

Public Health. [PDF]

Alzheimers Dement
Chi NC, Lozier P, Street N, Buckwalter K, Rakel B, Gardner S, Perkhounkova Y, Hein M, Yew PY, Chi CL, Gusen NJ.   +10 more
europepmc   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

A Study of the Correlation Between the Inflammatory Index and Disease Activity in Ulcerative Colitis. [PDF]

Int J Gen Med
Chenfei Z, Ainiwaer Z, Xiaoling H.
europepmc   +1 more source

Alpinetin Nanoparticles Alleviate Optic Nerve Injury Induced by Acute Glaucoma via LRP1‐PPARγ Mediated Regulation of Microglial Lipid Metabolism

Advanced Science, EarlyView.
Microglial lipid metabolic dysfunction drives neurodegeneration in glaucoma. We found loss of LRP1 causes lipid accumulation and inflammation. We developed alpinetin‐loaded nanoparticles (AlpNPs) that bind LRP1, activate the PPARγ‐LXRα‐ABCA1 pathway to restore lipid homeostasis, promote an anti‐inflammatory phenotype, and protect retinal ganglion cells,
Miao Wei, Yujia Huo, Jingchang Yuan, Xiao Fan, Xiaochen Wang, Sisi Tan, Xi Gao, Ruotong Ouyang, Hong Li   +8 more
wiley   +1 more source

Lipoprotein(a) and recurrent atherosclerotic cardiovascular events: the US Family Heart Database. [PDF]

Eur Heart J
MacDougall DE, Tybjærg-Hansen A, Knowles JW, Stern TP, Hartsuff BK, McGowan MP, Baum SJ, Wilemon KA, Nordestgaard BG.   +8 more
europepmc   +1 more source

Trigonelline Improves Metabolism and Cardiac Function of HFpEF Mice Via Gut Microbiome Alterations‐Mediated AMPK Activation

Advanced Science, EarlyView.
Metabolomics analyses reveal that trigonelline is markedly reduced in HFpEF hearts. Trigonelline supplementation alleviates metabolic disorders and improves cardiac function in HFpEF mice via gut microbiota‐mediated AMPK activation. Abstract Heart failure with preserved ejection fraction (HFpEF) is a prevalent end‐manifestation of cardiovascular ...
Zhe Cheng, Xiaowen Wang, Jiang Yu, Xiaorong Li, Qing Tang, Can Qu, Ding Yang, Yuanjing Li, Yong Xia, Yongzheng Guo   +9 more
wiley   +1 more source

Age- and sex-specific lipoprotein profiles in general and cardiometabolic population cohorts. [PDF]

EBioMedicine
Conde R, Gil-Redondo R, Bizkarguenaga M, Lodge S, Nitschke P, de Diego Á, González-Valle B, Hui J, Hunter ML, Yeap BB, Cenarro A, Lope V, Habisch H, Haudum C, Verheyen N, Obermayer-Pietsch B, Zaro Bastanzuri MJ, González Fernández MR, Fernández-Bergés D, Salazar AM, Sorando-Fernandez MP, Meijide S, Hernandez G, Arana E, Seco ML, Sousa A, Oliveira N, Verde I, Madl T, Unda-Urzaiz M, Carracedo A, Diercks T, Castelló A, Schäfer H, Spraul M, Cannet C, Embade N, Valenti L, Civeira F, Lu SC, Holmes E, Wist J, Nicholson JK, Mato JM, Millet O.   +44 more
europepmc   +1 more source

Utility of Non-High-Density Lipoprotein Cholesterol to High-Density Lipoprotein Cholesterol Ratio in Evaluating Incident Diabetes Risk

, 2022
Guotai Sheng, Dingyang Liu, Maobin Kuang, Yanjia Zhong, Shuhua Zhang, Yang Zou   +5 more
openalex   +2 more sources

Parallel Genome‐Wide CRISPR Screens Reveal SORL1 and ZFYVE19 as Sequential Host Determinants of Salmonella Infection

Advanced Science, EarlyView.
To distinguish how Salmonella invades cells vs how it survives long‐term, a parallel CRISPR screening platform is developed. This approach reveals the host proteins that the bacterium exploits at different stages of infection. The study identifies SORL1 as a novel host factor for invasion and demonstrates that blocking it with an antibody effectively ...
Sehee Yun, Seoyeon Kim, Seonggyu Kim, Minsoo Noh, Dae‐Kyum Kim, Eun‐Jin Lee, Hunsang Lee   +6 more
wiley   +1 more source

Correction: Comprehensive biomarker analysis of metabolomics in different syndromes in traditional Chinese medical for prediabetes mellitus. [PDF]

Chin Med
Lan Q, Li X, Fang J, Yu X, Wu ZE, Yang C, Jian H, Li F.   +7 more
europepmc   +1 more source