Results 11 to 20 of about 93,526 (325)

Lipoprotein lipase [PDF]

Journal of Lipid Research, 2002
Lipoprotein lipase (LPL) regulates the plasma levels of triglyceride and HDL. Three aspects are reviewed. 1) Clinical implications of human LPL gene variations: common mutations and their effects on plasma lipids and coronary heart disease are discussed.
Martin Merkel, Robert H. Eckel, Ira J. Goldberg   +2 more
doaj   +4 more sources

Lipoprotein lipase and acid lipase activity in rabbit brain microvessels.

Journal of Lipid Research, 1979
A preparation of cerebral microvessels was used to demonstrate the presence of lipoprotein lipase and acid lipase activity in the microvasculature of rabbit brain. Microvessels, consisting predominantly of capillaries, small arterioles, and venules, were
P Brecher, H T Kuan
doaj   +2 more sources

Striated muscle gene therapy for the treatment of lipoprotein lipase deficiency. [PDF]

PLoS ONE, 2018
Excessive circulating triglycerides due to reduction or loss of lipoprotein lipase activity contribute to hypertriglyceridemia and increased risk for pancreatitis.
Katherine E Gadek, Hong Wang, Monica N Hall, Mitchell Sungello, Andrew Libby, Drew MacLaskey, Robert H Eckel, Bradley B Olwin   +7 more
doaj   +1 more source

Stabilizing lipoprotein lipase [PDF]

Journal of Lipid Research, 2009
Evidence from several prospective observational studies points toward the independent predictive value of plasma triglycerides in assessing cardiovascular risk (1). Hence, plasma triglycerides are increasingly targeted as a specific cardiovascular treatment outcome.
Kersten, A.H., Bensadoun, A.
openaire   +3 more sources

Over-expression of human lipoprotein lipase in mouse mammary glands leads to reduction of milk triglyceride and delayed growth of suckling pups. [PDF]

PLoS ONE, 2011
BACKGROUND: The mammary gland is a conserved site of lipoprotein lipase expression across species and lipoprotein lipase attachment to the luminal surface of mammary gland vascular endothelial cells has been implicated in the direction of circulating ...
Yuanyuan Wang, Jia Tong, Shuping Li, Ran Zhang, Li Chen, Yuhui Wang, Min Zheng, Meili Wang, George Liu, Yunping Dai, Yaofeng Zhao, Ning Li   +11 more
doaj   +1 more source

Homology of lipoprotein lipase to pancreatic lipase. [PDF]

Proceedings of the National Academy of Sciences, 1986
Bovine milk lipoprotein lipase was subjected to amino acid sequence analysis. The first 19 amino-terminal residues were Asp-Arg-Ile-Thr-Gly-Gly-Lys-Asp-Phe-Arg-Asp-Ile-Glu-Ser-Lys-Phe-Ala-Leu- Arg. In addition, reversed-phase high-performance liquid chromatography of a tryptic digest of reduced and alkylated lipase resolved a number of peptides, five ...
Mary E. Pedersen, Michael C. Schotz, Chad Miller Ben-Avram, Kristen Haaga, Joseph R. Reeve, John Goers, Terry D. Lee, John E. Shively, Osnat Ben-Zeev   +8 more
openaire   +3 more sources

Lipoprotein lipase is active as a monomer [PDF]

Proceedings of the National Academy of Sciences, 2019
Significance Lipoprotein lipase (LPL) plays a central role in plasma lipid metabolism, hydrolyzing the triglycerides in lipoproteins and releasing fatty acid nutrients for vital tissues. LPL is synthesized by adipocytes and myocytes and secreted into the interstitial spaces, whereupon it is captured by an endothelial cell protein, GPIHBP1 ...
Stephen G. Young, Stephen G. Young, Muthuraman Meiyappan, Gabriel Birrane, Christopher M. Allan, Katsuyuki Nakajima, Patrick J Heizer, Kazuya Miyashita, Masami Murakami, Norma P. Sandoval, Anne P. Beigneux, Loren G. Fong, Michael Ploug, John E Gill, Peter J. Havel, Kimber L. Stanhope, Geoffrey W Cho, Rachel S. Jung   +17 more
openaire   +4 more sources

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

The mechanism of heparin stimulation of rat adipocyte lipoprotein lipase

Journal of Lipid Research, 1969
Free fat cells and stromal-vascular cells were prepared from rat adipose tissue by incubation with collagenase. NH4OH-NH4Cl extracts of acetone-ether powders prepared from fat cells contained lipoprotein lipase activity but extracts of stromal-vascular ...
R.L. Patten, C.H. Hollenberg
doaj   +1 more source