Results 11 to 20 of about 45,979 (322)

The Importance of Lipoprotein Lipase Regulation in Atherosclerosis [PDF]

Biomedicines, 2021
Lipoprotein lipase (LPL) plays a major role in the lipid homeostasis mainly by mediating the intravascular lipolysis of triglyceride rich lipoproteins. Impaired LPL activity leads to the accumulation of chylomicrons and very low-density lipoproteins (VLDL) in plasma, resulting in hypertriglyceridemia.
Anni Kumari, Anne-Marie Lund Winther, Anne-Marie Lund Winther, Michael Ploug, Michael Ploug, Kristian Kølby Kristensen, Kristian Kølby Kristensen   +6 more
openaire   +6 more sources

Lactic acid bacteria isolated from traditional Iranian butter with probiotic and cholesterol‐lowering properties: In vitro and in situ activity

Food Science &Nutrition, Volume 11, Issue 1, Page 350-363, January 2023., 2023
Traditional Iranian butter samples were collected from different parts of Iran and were screened for the presence of Lactic acid bacteria. The selected LAB were identified to species level by biphasic approach. The ability of selected LAB to lower the cholestrol both in vitro and in situ was then determined.
Mahbubeh Ostadzadeh, Mohammad B. Habibi Najafi, Mohammad R. Ehsani   +2 more
wiley   +1 more source

Lactobacillus paracasei N1115 attenuates obesity in high‐fat diet‐induced obese mice

Food Science &Nutrition, Volume 11, Issue 1, Page 418-427, January 2023., 2023
Lactobacillus paracasei N1115 relieved high fat diet induced obesity. Lactobacillus paracasei N1115 decreased body weight, fat accumulation and hyperlipidemia by increasing the abundance of beneficial bacteria (Allobaculum and L. Zeae) and decreased harmful bacteria (Turicibacter).
Yanan Sun, Shanbin Chen, Fazheng Ren, Yixuan Li   +3 more
wiley   +1 more source

The anti‐obesity and anti‐diabetic effects of the edible seaweed Gloiopeltis furcata (Postels et Ruprecht) J. Agardh in mice fed a high‐fat diet

Food Science &Nutrition, Volume 11, Issue 1, Page 599-610, January 2023., 2023
Edible red seaweed G. furcata alleviates obesity and associated metabolic disorders in mice fed a high fat diet by suppressing intestinal lipid absorption, oxidative stress and inflammation. Abstract Obesity and diabetes are serious, chronic medical conditions associated with a wide range of life‐threatening conditions.
Shigeru Murakami, Chihiro Hirazawa, Toshiki Mizutani, Rina Yoshikawa, Takuma Ohya, Ning Ma, Yutaka Owaki, Toyohiro Owaki, Takashi Ito, Chiaki Matsuzaki   +9 more
wiley   +1 more source

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Fibrotic and inflammatory characteristics of epidural fat adjacent to the ossification area in patients with ossification of the ligament flavum

JOR SPINE, Volume 5, Issue 4, December 2022., 2022
We observed the histological and inflammatory characteristics of epidural fat (EF) adjacent to the ossification area in patients with ossification of the thoracic ligament flavum (TOLF) and provide a preliminary basis for investigating the impact of EF on OLF. Morphologically, EF exhibits no significant differences between the TOLF and non‐TOLF groups,
Xinyu Dou, Tianli Mao, Yunlong Ma, Fei Jia, Yu Liu, Xiaoguang Liu   +5 more
wiley   +1 more source

Correctly validating results from single molecule data: the case of stretched exponential decay in the catalytic activity of single lipase B molecules [PDF]

Chem. Phys. Lett. 432, 371-374 (2006), 2007
The question of how to validate and interpret correctly the waiting time probability density functions (WT-PDFs) from single molecule data is addressed. It is shown by simulation that when a stretched exponential WT-PDF, with a stretched exponent alfa and a time scale parameter tau, generates the off periods of a two-state trajectory, a reliable ...
arxiv   +1 more source

Molecular rules for selectivity in lipase-catalysed acylation of lysine [PDF]

Process Biochemistry, Elsevier, 2018, 74, pp.50-60, 2019
The selectivity of L-lysine acylation by lauric acid catalysed by Candida antarctica lipase B (CALB) was investigated combining experimental and theoretical methodologies. Experiments showed the near-exclusive acylation of lysine $\epsilon$-amino group; only traces of product resulting from the acylation of lysine $\alpha$-amino group were observed ...
arxiv   +1 more source

Per‐ and polyfluoroalkyl substances activate UPR pathway, induce steatosis and fibrosis in liver cells

Environmental Toxicology, Volume 38, Issue 1, Page 225-242, January 2023., 2023
Abstract Per‐ and polyfluoroalkyl substances (PFAS), which include perfluorooctanoic acid (PFOA), heptafluorobutyric acid (HFBA), and perfluorotetradecanoic acid (PFTA), are commonly occurring organic pollutants. Exposure to PFAS affects the immune system, thyroid and kidney function, lipid metabolism, and insulin signaling and is also involved in the ...
Qi Qi, Suryakant Niture, Sashi Gadi, Elena Arthur, John Moore, Keith E. Levine, Deepak Kumar   +6 more
wiley   +1 more source