Results 41 to 50 of about 45,979 (322)

The contribution of extracellular RNA and its derived biomaterials in disease management

BMEMat, EarlyView.
The implications of exRNA's biological function and the structural uniqueness of RNA help establish a close connection between RNA, material, and modern medicine. Abstract The RNA found in the circular system is known as extracellular RNA (exRNA). This kind of RNA has been found to play a biological role similar to that of a messenger. They can be used
Yu Wei, Zhangyi Wang, Zixuan Qin, Qianqian Wan, Yutao Li, Franklin R. Tay, Chenyu Wang, Tong Zhang, Lina Niu   +8 more
wiley   +1 more source

ANGPTL3 (Angiopoietin‐Like 3) Preferentially Resides on High‐Density Lipoprotein in the Human Circulation, Affecting Its Activity

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background ANGPTL3 (angiopoietin‐like protein 3) is an acknowledged crucial regulator of lipid metabolism by virtue of its inhibitory effect on lipoprotein lipase and endothelial lipase.
Jordan M. Kraaijenhof, Tycho R. Tromp, Nick S. Nurmohamed, Laurens F. Reeskamp, Marije Langenkamp, Johannes H. M. Levels, S. Matthijs Boekholdt, Nicholas J. Wareham, Menno Hoekstra, Erik S. G. Stroes, G. Kees Hovingh, Aldo Grefhorst   +11 more
doaj   +1 more source

Structural, Spectroscopic, and Docking Analysis of N,O‐Donor Ligand Metal Complex Nanoparticles With Hypolipidemic Effects via Lipoprotein Lipase Activation in High‐Fat Diet Mice

Chemistry &Biodiversity, EarlyView.
Hypolipidemic influence of CETZ.2HCl‐(H1‐antihistamine) metal‐complexes on “C57Bl/6‐mice” fed high‐fat‐diet. ABSTRACT New Cd(II), Zn(II), and Cu(II) chelates with cetirizine.2HCl (CETZ.2HCl) in incidence of 1,10 phenanthroline monohydrate (Phen.H2O) were synthesized in search of new biologically active compounds.
Sherif M. Abd El‐Hamid, Safa W. Aziz, Amira A. Mohamed, Mohammed S. El‐Gedamy, Ahmed E. Salem, Soha F. Mohammed, Wael A. Zordok, Adriano Sofo, Mohamed A. Sabry, Sadeek A. Sadeek, Hazem S. Elshafie   +10 more
wiley   +1 more source

Profiling Serine Hydrolases in the Leishmania Host‐Pathogen Interactome Using Cell‐Permeable Activity‐Based Fluorophosphonate Probes

ChemBioChem, Accepted Article.
Leishmaniasis, a vector borne neglected tropical disease, caused by the protozoan parasite Leishmania, is a major global public health challenge with millions of new cases annually. Treatment of leishmaniasis is difficult for many reasons including a multiple life‐cycle stages, involving both an infective insect vector form, the promastigote, and a ...
Jaime A. Isern, Exequiel O.J. Porta, Karunakaran Kalesh, Zisis Koutsogiannis, Davide Cazzola, Ehmke Pohl, Paul Denny, Patrick G. Steel   +7 more
wiley   +1 more source

Effect of epinephrine and other lipolytic agents on intracellular lipolysis and lipoprotein lipase activity in 3T3-L1 adipocytes.

Journal of Lipid Research, 1987
3T3-L1 adipocytes were used to test the hypothesis that hormone-sensitive lipolysis and lipoprotein lipase activity might be regulated in a reciprocal manner.
S S Chernick, P M Spooner, M M Garrison, R O Scow   +3 more
doaj  

A new lipid-structured model to investigate the opposing effects of LDL and HDL on atherosclerotic plaque macrophages [PDF]

arXiv, 2022
Atherosclerotic plaques form in artery walls due to a chronic inflammatory response driven by lipid accumulation. A key component of the inflammatory response is the interaction between monocyte-derived macrophages and extracellular lipid. Although concentrations of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles in the blood
arxiv  

Tau‐targeting nanoparticles for treatment of Alzheimer's disease

Exploration, EarlyView.
Through review of comprehensive literature and research studies, it is found that tau‐targeting nanoparticles may posit beneficial applications to AD therapy. By targeting a key molecular mechanism known to propagate AD pathogenesis, tau‐targeting nanoparticles have the potential to facilitate tau tangle clearance, promote synaptic integrity, and ...
Shreya Pawar, Mohd Ahmar Rauf, Hosam Abdelhady, Arun K. Iyer   +3 more
wiley   +1 more source

Embracing nanotechnology for selenium application in aquafeeds

Reviews in Aquaculture, Volume 15, Issue 1, Page 112-129, January 2023., 2023
Abstract Selenium (Se) is an important micronutrient that has been used in aquafeeds for the normal growth, welfare and health of aquatic animals. Through nanotechnology, Se can be converted into nanoparticles that are more bioavailable, utilized and absorbed by aquatic animals.
Hala Saber Khalil, Sahya Maulu, Marc Verdegem, Mohsen Abdel‐Tawwab   +3 more
wiley   +1 more source

Lipoprotein lipase and hepatic lipase

Journal of Lipid Research, 2003
HDL subspecies Lp(A-I) and Lp(A-I,A-II) have different anti-atherogenic potentials. To determine the role of lipoprotein lipase (LPL) and hepatic lipase (HL) in regulating these particles, we measured these enzyme activities in 28 healthy subjects with ...
Marian C. Cheung, Shalamar D. Sibley, Jerry P. Palmer, John F. Oram, John D. Brunzell   +4 more
doaj  

A Computational Methodology to Screen Activities of Enzyme Variants [PDF]

, 2012
We present a fast computational method to efficiently screen enzyme activity. In the presented method, the effect of mutations on the barrier height of an enzyme-catalysed reaction can be computed within 24 hours on roughly 10 processors. The methodology is based on the PM6 and MOZYME methods as implemented in MOPAC2009, and is tested on the first step
arxiv   +1 more source