Results 171 to 180 of about 212,593 (281)

Chronic high‐fat diet induces multi‐organ dysfunction and metabolic homeostasis disruption in Macaca fascicularis

Animal Models and Experimental Medicine, EarlyView.
An 18‐month HFD successfully established a translational Macaca fascicularis model replicating key metabolic disorders (MASH, diabetes, cardiac hypertrophy). MASH was determined by liver biopsy histology, the presence steatosis, inflammatory infiltration, hepatocytic ballooning, and fibrosis were considered as MASH; diabetes was diagnosed according to ...
Hongyi Chen, Wei Liu, Dan Zhou, Shuhua Liu, Yalun Guan, Zongyu Miao, Lei Cai, Xuejiao Li, Yunfeng Li, Zhongqiang Huang, Yi Jin, Ge Li, Yu Zhang   +12 more
wiley   +1 more source

Endothelial Cell Regulation of Lipid Uptake During Feeding and Fasting. [PDF]

Arterioscler Thromb Vasc Biol
Goldberg IJ, Tirumalasetty M, Peche VS, Gaballa R, Cabodevilla AG, Komack M, Miao QR, Abumrad NA.   +7 more
europepmc   +1 more source

Establishment of a mouse model of TMAO‐induced cardiac injury and application of MICT intervention

Animal Models and Experimental Medicine, EarlyView.
This study aims to explore the establishment of an animal model of cardiac injury induced by trimethylamine‐N‐oxide (TMAO), a metabolite secreted by gut microorganisms, and to investigate its application in moderate‐intensity continuous training (MICT) intervention.
Zhongping Xie, Hong Zou, Lijing Gong, Minghui Lin, Caihua Huang   +4 more
wiley   +1 more source

Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis

Animal Models and Experimental Medicine, EarlyView.
This schematic illustrates the proposed mechanism. In advanced atherosclerotic lesions, upregulated CLU on the cell surface activates low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1). This interaction triggers the phosphorylation and activation of AKT.
Dengfeng Ding, Yingjie Zhang, Li Zhang, Xinou Zheng, Miaomiao Niu, Yunxiao Jia, Xuezhuang Li, Hua Chen, Chao Guo, Tao Jiang, Yuqiong Zhao   +10 more
wiley   +1 more source

Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice

Annals of Neurology, EarlyView.
A Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone body produced by the ketogenic diet, may mediate its ...
Soudabeh Naderi, John Williamson, Huayu Sun, Suchitra Joshi, Rachel Jane Spera, Savaira Zaib, Supriya Sharma, Chengsan Sun, Andrey Brodovskiy, Ifrah Zawar, Jaideep Kapur   +10 more
wiley   +1 more source

Diabetes Mellitus and Lipoprotein(a): A Determinant Interaction in Micro- and Macrovascular Damage. [PDF]

Int J Mol Sci
Polo-Barranco A, Rebolledo-Maldonado C, Esquiaqui-Rangel V, Nuñez-Mejia A, Rambal-Torres J, Barraza-Ahumada V, Vargas-Cantillo S, Benavides-De la Cruz W, Liñán-Martínez V, Rada-Obeso V, Isaac-Escorcia M, Martínez-Fontalvo N, Correa-Guerrero J, Rodelo-Barrios D, Osorio-Rodríguez E.   +14 more
europepmc   +1 more source

Mandible composition and properties in two selected praying mantises (Insecta, Mantodea)

The Anatomical Record, EarlyView.
Abstract Insects process their food with their cuticle‐based mouthparts. These feeding structures reflect their diversity and can, in some cases, showcase adaptations in material composition, mechanical properties, and shape to suit their specific dietary preferences.
Malo Roze, Stanislav N. Gorb, Timo Zeimet, Wencke Krings   +3 more
wiley   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

Dual Functions of Dietary Rubber Seed Oil Supplementation: Enriching N‐3 Polyunsaturated Fatty Acids and Enhancing Antioxidant Capacity in Pekin Ducks

Animal Research and One Health, EarlyView.
Dietary RSO supplementation improved growth performance, simultaneously enriched n‐3 polyunsaturated fatty acids (n‐3 PUFA), and enhanced antioxidant capacity in Pekin ducks, which suggested that RSO has the potential to be a novel n‐3 PUFA source and an antioxidant for Pekin ducks to generate animal functional foods.
Lei Zhuang, Yongbao Wu, Zitao Zhao, Junting Cao, Yanhong Guo, Zhanyue Wu, Qimeng Wang, Peilong Yang, Sen Wu, Zhiguo Wen, Shuisheng Hou   +10 more
wiley   +1 more source

Concerns regarding lipid metabolism, immune regulation, and methodology in a study on esophageal cancer lymph node metastasis. [PDF]

World J Gastrointest Surg
Cui X, Liang Z.
europepmc   +1 more source