Results 161 to 170 of about 161,796 (303)

Characterization of aliA and aliB deletion mutants reveals a dominant role of AliA in Haloferax volcanii lipoprotein lipidation. [PDF]

J Biol Chem
Hong Y, Garcia A, Kopelev S, Cote JA, Pfeiffer F, Welander P, Schulze S, Pohlschroder M.   +7 more
europepmc   +1 more source

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

A Shared Chemokine Signature of Triglyceride-Rich Lipoproteins and lipoprotein(a): Driver or Bystander? [PDF]

JACC Basic Transl Sci
Mousa M, Kroon J.
europepmc   +1 more source

Sonogenetic Control of Engineered Probiotics for the Treatment of MASH by Modulating the Gut‐Liver Axis

Advanced Science, EarlyView.
Researchers developed an engineered probiotic encapsulated in an inulin hydrogel, enabling ultrasound‐triggered intestinal delivery of IL‐22. In MASH model mice, this system remodeled gut microbiota, strengthened the intestinal barrier and reduced portal LPS and hepatic IL‐6.
Chunya Ji, Yan Fang, Shen Zhang, Weichen Xu, Wenyun Guo, Jing Chen, Mingrui Zhu, Congjian Wen, Siming Chen, Yuli Zhu, Huixiong Xu, Haohao Yin   +11 more
wiley   +1 more source

Circulating lipids, lipoproteins, and the risk of idiopathic pulmonary fibrosis: a cohort study and genetic analysis. [PDF]

J Lipid Res
Zhu J, Shen Y, Yan Z, You Z, Chen L, Zhao X, Zhou D, Li Y.   +7 more
europepmc   +1 more source

Yoda1‐Functionalized Nanozymes Coordinate Piezo1 Activation and Mitochondrial Protection to Reprogram the Diabetic Osteoimmune Micromilieu and Promote Vascularized Bone Repair

Advanced Science, EarlyView.
Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng, Ang Wang, Ren Zhang, Xu‐Ran Li, Po‐Lin Liu, Shu‐Hang He, Zi‐Yin Han, Zhi‐Han Shen, Zhan‐Ying Wei, Chang‐Ru Zhang, Fei Wang, Helen Dawes, Jian Lu, Tong‐He Zhu, Jin‐Zhong Zhao, Shang‐Chun Guo, Shi‐Cong Tao   +16 more
wiley   +1 more source

Abetalipoproteinemia With a Novel Microsomal Triglyceride Transfer Protein Gene Mutation and Unique Oxidized Lipoprotein Levels. [PDF]

J Med Cases
Hamasaki M, Hara K, Kotani K.
europepmc   +1 more source

An Integrated Artificial Intelligence Framework for Nanomedicine Engineering

Advanced Science, EarlyView.
This review outlines a closed‐loop AI ecosystem for nanomedicine engineering. By synergizing multimodal data harmonization, objective‐driven AI architectures, and automated high‐throughput validation, this “Design‐Make‐Test‐Analyze” (DMTA) workflow transforms traditional heuristic formulation into a predictive, self‐optimizing paradigm, accelerating ...
Meichen Dong, Qin Luo, Xinyi Ding, Chaoqi Lu, Ru Zhang, Qingqing Tan, Zhiqing Pang, Defang Ouyang, Dongsheng Li, Jiaxuan Xia, Jianxin Wang   +10 more
wiley   +1 more source

Lipoprotein Corona Reshapes the Internal Structure of Lipid Nanoparticles. [PDF]

ACS Nano
Caselli L, Rojas-Rodríguez M, Pacciani V, Calamai M, Frigerio R, Zendrini A, Sanità G, Esposito E, Leung A, Wacklin-Knecht H, Humphreys B, Arosio P, Cardellini J, Berti D.   +13 more
europepmc   +1 more source

Lipoproteins induce tyrosine phosphorylation in human natural killer cells

, 1998
Lipoproteins, chylomicrons (CM), very low density lipoprotein (VLDL), low density lipoprotein (LDL), high density lipoprotein (HDL) and acetyl modified LDL (AcLDL) can stimulate natural killer (NK) cells upon binding to specific receptors.
Blanca, Isaac, Bianco Colmenares, Nicolás E., De Sanctis, Juan B.   +2 more
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