Results 101 to 110 of about 114,873 (244)

Emerging roles of liposomal bupivacaine in anesthesia practice

, 2017
Despite advances in drug technology and improvements in technology, including peripheral nerve catheters and ultrasound, postoperative pain is still a significant problem in the clinical setting worldwide.
Richard D Urman, Alan D Kaye, Aaron Kaye, Kumar Belani, Obaid Malik, AlanD Kaye, RichardD Urman   +6 more
core   +1 more source

Efficacy and safety of liposomal bupivacaine versus bupivacaine for retrolaminar block for postoperative analgesia in patients undergoing posterior lumbar interbody fusion: a randomized controlled trial

BMC Anesthesiology
Background This study compared the analgesic effects and adverse effects of liposomal bupivacaine and bupivacaine in patients undergoing posterior lumbar interbody fusion (PLIF) with retrolaminar block (RLB).
Shi-Jiao Zhang, Yang Liu, Yong-qian Wei, Xiang-yu Ma, Ying-bin Wang   +4 more
doaj   +1 more source

Efficacy and safety of liposomal bupivacaine administration in the pediatric population: a scoping review of the literature

Anesthesiology and Perioperative Science
Liposomal bupivacaine (LB; Exparel) is a slow-release formulation of bupivacaine used for postoperative pain control that allows for steady and sustained release of bupivacaine over an extended period of time. Although it has been thoroughly investigated
Tarika D. Patel, Matthew Dusza, Cheng-ting Lee   +2 more
semanticscholar   +1 more source

Effect of different liposomal bupivacaine concentrations in ultrasound-guided superior trunk block on postoperative analgesia and mobility: a randomized double-blind controlled trial protocol for shoulder arthroscopy

Annals of Medicine
Background Shoulder arthroscopy frequently causes severe postoperative pain that may impede recovery. Liposomal bupivacaine provides prolonged analgesia, and ultrasound-guided superior trunk block (STB) offers comparable analgesia to interscalene block ...
Yu Zhou, Hong-Zhang Ding, Xiao-Qian Li, Teng Zheng, Mao-Lin Ran, Ai-Ling Song, Yi-Min Qiu, Jin-Bao Li, Feng Chen   +8 more
doaj   +1 more source

Comparison of Pharmacokinetics of Long-Acting Local Analgesics: CPL-01, a Novel Extended-Release Ropivacaine, Demonstrates Consistent and Predictable Exposure Compared with Liposomal Bupivacaine

Clinical drug investigation
There is a significant medical need for improved long-acting local anesthetics to decrease postsurgical pain and reduce postoperative opioid use. While ropivacaine is considered a safer local anesthetic than bupivacaine, no long-acting ropivacaine ...
Stevie Pope, Christopher Crean, Sarah Thrasher, Hanghang Xu, P.-J. Chen, Lee Chen, DeeDee Hu, E. Onel   +7 more
semanticscholar   +1 more source

Antinociceptive Effect of Liposomal Bupivacaine Formulations After Intrathecal Administration in Rats

, 2019
Background/aim: Based on our previous in vitro study with multilamellar liposomal bupivacaine (MLB) versus bupivacaine alone in artificial cerebrospinal fluid, we aimed to investigate in vivo antinociceptive effect of intrathecal MLB by determining tail ...
Degim, Tuncer, Bal, Nur Banu, Emmez, Ömer Hakan, Yigit, Ilker, Uludag, Orhan, Gunaydin, Berrin   +5 more
core   +1 more source

Does Liposomal Bupivacaine Reduce Postoperative Pain Following Third Molar Extractions? A Double-Blinded Randomized Controlled Trial

Journal of oral and maxillofacial surgery
Background: Liposomal bupivacaine (LB) is a long-lasting local anesthetic providing analgesia for several days. Current literature examining the efficacy of LB in pain management following third molar extractions remains unclear.
Simon Youn, Katherine Scheker, Samuel Sheridan, C. Hayashi, Trevor A. Pickering, John Costandi   +5 more
semanticscholar   +1 more source

Admixture of Liposomal Bupivacaine and Bupivacaine Hydrochloride for Peripheral Nerve Blocks in Adolescents Undergoing Orthopedic Surgery: An Observational Cohort Study

Background/Objectives: In 2021, the Food and Drug Administration approved liposomal bupivacaine injectable suspension for single-dose infiltration in patients ≥ 6 years of age. Liposomal bupivacaine and bupivacaine hydrochloride admixtures may also be
Benjamin P. Fiorillo, M. Stephen Melton, Lisa M. Einhorn, Derek Nelsen   +3 more
core   +1 more source

Liposomal Bupivacaine-Based Regional Anesthesia Provides Excellent Pain Control and Minimizes Opioid Consumption Following Anterior Cruciate Ligament Reconstruction: A Prospective Randomized Controlled Trial

Orthopaedic Journal of Sports Medicine
Objectives: Femoral nerve blockade (FNB), adductor canal blocks (ACB) and the interspace between the popliteal artery and capsule of the posterior knee (IPACK) blocks are common techniques for regional analgesia following anterior cruciate ligament (ACL)
William L. Johns, Benjamin Miltenberg, Armen Voskeridjian, Christopher Dodson MD, Michael Ciccotti MD, Steven Cohen MD, Rahul Muchintala, John Salvo, Sommer Hammoud MD   +8 more
doaj   +1 more source

Contamination of liposomal bupivacaine during multi-dose usage in a clinical setting evaluated by culture and PCR

Frontiers in Veterinary Science
IntroductionLiposomal bupivacaine, a long-acting local anesthetic, is sold in single-dose vials at a cost of approximately $200/20 mL vial. As many veterinary patients are not dosed an entire vial, the vials have been used for multiple doses at our ...
Rachel L. Melvin, Jing Wu, Brad S. Bennett, Sara D. Lawhon, Amy Savarino, Artem S. Rogovskyy, Kelley M. Thieman Mankin   +6 more
doaj   +1 more source